Interactions of two active pharmaceutical ingredient ionic liquids (API-ILs) tetradecylpyridinium dl -mandelic acid ([TetPy][MAN]) and cetylpyridinium dl -mandelic acid ([CetPy][MAN]) with some small biomolecules have been studied by using conductometric, density and UV–vis spectroscopic techniques. The chosen small biomolecules are glycine, l -alanine, l -valine, l -leucine and glycylglycine (AAGG). The critical micelle concentration ( cmc ) of [TetPy][MAN] and [CetPy][MAN] in aqueous AAGG solution is calculated from the measured conductance values, thus yielding some thermodynamic parameters of the micellization, such as the standard Gibbs energy change ( Δ G m 0 ) , the standard enthalpy change ( Δ H m 0 ) and the standard entropy change ( Δ S m 0 ) . On the basis of the experimental densities of ternary solutions of (AAGG + API-ILs + water), apparent molar volume at infinite dilution ( V 2 , φ 0 ), apparent molar expansibility at infinite dilution ( E φ 0 ) , transfer partial molar volume ( Δ t V 0 ) and hydration number ( n H ) of AAGG in aqueous API-ILs solution were calculated. The dominant hydrophobic-hydrophilic and hydrophobic-hydrophobic interactions were involved in the investigated systems. The binding constant ( K b ) between AAGG and API-ILs has been calculated from UV–vis spectroscopic data. Effect of some factors including concentration, temperature, molecular structure, etc. on the aforementioned parameters and the existing solvent–solute interaction has been discussed.
Chiral stationary phases (CSPs) have always been research hotspot in enantiomer separation. Currently, most of the CSPs are based on silica platform. In this research, monodisperse, porous glycidyl methacrylate-divinylbenzene copolymer particles (poly(GMA-DVB)) were designed and prepared. Then the GMA was further reacted with ethylenediamine to introduce amino groups onto the polymer, which provide anchoring sites for cellulose derivatives. Herein, Cellulose-tris (3,5-dimethylphenylcarbamate) (CDMPC) was successfully coated onto the polymer microspheres, achieving a stable and successful CSP. The porous structure and the surface moieties of the CSPs were studied in detail. The chromatographic separation was optimized. Hexaconazole,methyl DL-mandelate,benzoin and tebuconazole have been successfully separated on the CSP column, with column efficiency as high as 10,200 plates/m, which is comparable with some silica-based CSPs. The research has indicated that the poly(GMA-DVB) is a promising candidate for constructing CSPs for chiral separation.
危险品化学品经营许可证（带存储）