Heteropoly acid-catalyzed three-component aza-Diels–Alder reaction in a continuous micro-flow system
The first direct aza-Diels–Alder reaction catalyzed using phosphotungstic acid combined with a water absorption device in a micro-flow system was reported. The optimization process gave azabicyclo[2.2.2]octan-5-ones in 98.78% conversion and an endo/exo ratio of 7/93. Exo cycloadducts were quickly prepared due to efficient mixing and heat transfer in the micro-flow system. However, exo products could be turned into endo cycloadducts which were more stable.
研究领域:
有机化学
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催化化学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）