SCIENCE OF THE TOTAL ENVIRONMENT
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2025
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IF 8
Jing Lu,Hongdi Wei,Xinyu Yao,Yuelin Chen,Meitong Liu,Shuang Guan
Glycidol is a common food contaminant, and its main target organ is the kidney. However, the mechanism of nephrotoxicity of glycidol has not been fully elucidated. In this paper, we investigated the mechanism of glycidol toxicity in mice kidneys and NRK-52E cells. We found that glycidol exposure induced necroptosis in renal cells through the RIPK1/RIPK3/MLKL pathway. Mechanistically, it was further found that glycidol blocked renal cell autophagy and induced ectopic aggregation of p62. Accumulated p62 recruited RIPK1 and activated downstream RIPK1/RIPK3/MLKL necrosome production. At the same time, the accumulated p62 could also participate in the activation of intracellular NF-κB nuclear transcription factor by interacting with RIPK1 to form a signalling complex, which promoted the secretion of inflammatory factors TNF-α and IL-1β, and induced inflammation in the kidney. Our present study provided a new understanding of the complex mechanism of glycidol on renal injury.
研究领域:
毒理学
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细胞生物学
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分子生物学
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DOI
PubMed
高影响因子
REACTIVE & FUNCTIONAL POLYMERS
·
2020
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IF 3.333
Qinglong Luo,Meiting Zeng,Xueying Wang,He Huang,Xuefeng Wang,Na Liu,Xueli Huang
This study describes two boron sorbents : P(GMA-co-TRIM)-EN-PG and P(GMA-co-TRIM)-TETA-PG. These absorbents were prepared by grafting glycidol onto P(GMA-co-TRIM) with different amounts of amino and imino groups . The structure was characterized using FT-IR, SEM and the water contact angle (WCA). The two adsorbents contain a large number of hydroxyl groups and are defined as nanomaterials . The adsorption of boron by the two adsorbents was investigated by determining the effects of pH, the initial boron concentration, adsorption time, ion competition and cycle life. Isothermal adsorption data were combined with the Langmuir adsorption isotherm model, and the adsorption kinetics were well fitted to the second-order kinetic model . The adsorption equilibrium was achieved within 60 min, and the maximum amounts of boron adsorbed were 29.22 mg/g and 23.25 mg/g, respectively. The presence of Na + , Mg 2+ , Ca 2+ , K + , Cl − , SO 4 2− and NO 3 − ions had little effect on boron adsorption. After five consecutive adsorption-desorption cycles, the two adsorbents showed good reuse performance. These two promising adsorbents are useful for removing boron from aqueous solutions.
研究领域:
环境科学
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材料科学
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DOI
高影响因子
Frontiers in Chemical Engineering
·
2026
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IF 2.6
Gideon Abaidoo Ocran,Bosong Zhang,Yi Zuo,Huali Tan,Gudan Li,Hong Yang,Chunshan Song,Xinwen Guo
The epoxidation of allyl alcohol with H2O2 over titanium silicalite-1 (TS-1) is an environmentally friendly route for producing glycidol. However, the catalytic activity and stability of TS-1 is not satisfactory. In this study, strip-shaped TS-1 was hydrothermally treated by TPAOH solution, change theTi coordination states and diffusion property, thereby enhancing its catalytic performance. The influences of TPAOH concentration and treating time on the physical chemical property and catalytic performance were studied systematically. It was found that the SiO2 agglomerant was dissolved and crystallized during the treatment, resulting in an increased Si content on the external surface. The tetrahedrally coordinated Ti was transformed to pentahedrally and octahedrally coordinated Ti, which possess higher catalytic activity for selective oxidation. The treatment also leads to the formation of cavities in the TS-1 crystals, which can shorten the diffusion pathway of substates and improve the diffusion property. Both the chemical property and microstructure enhance the catalytic activity for allyl alcohol epoxidation.
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高影响因子
Catalysts
·
2023
·Vol. 13
·期 5
·809
·
IF 3.9
Elrasheed Elhaj,Huajun Wang,Enaam A. Al-Harthi,Waseem A. Wani,Sahar Sallam,Nasser Zouli,Mohd Imran
In this work we demonstrate one-pot glycidol synthesis, via trans-esterification between glycerol and dimethyl carbonate, by making use of commercially available sodium methoxide as a catalyst. An excellent glycerol conversion (99%) and remarkable glycidol yield (75%) was obtained using dimethyl carbonate/glycerol (molar ratio 2:1) in the presence of 3 wt% catalyst amount (with respect to glycerol weight) at 85 °C for a reaction time of 120 min. Sodium methoxide was recycled and reused twice with only a slight decrease in glycerol conversion. The water content of the glycerol reached 2.5 wt%; this did not reduce the glycerol conversion efficiency of the catalyst. A plausible mechanism for the trans-esterification involved in the preparation of glycidol was proposed.Keywords:glycerol carbonate;one-pot glycidol synthesis;sodium methoxide-catalysed;stability of sodium methoxide catalyst;trans-esterification of glycerol
研究领域:
化学工程
·
催化化学
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DOI
高影响因子
Food Bioscience
·
2024
·
IF 4.8
Yuan Yuan,Xiaoxuan Yin,Lu Li,Ziyue Wang,Haiyang Yan
ABSTRACT Glycidol (CAS: 556-52-5), a known carcinogen and genotoxicant, is often found in refined vegetable oils. Human exposure predominantly occurs through consumption of these oils and their byproducts, which contain glycidyl esters (GEs). Upon ingestion, GEs are metabolized to release glycidol, posing substantial health hazards. Historical studies have reported the tumorigenic properties of glycidol across various organs in mice models, encompassing the stomach, liver, lungs, brain, mammary gland, and skin. In this study, we employed a Balb/c mice model to investigate the hepatotoxic effects of glycidol following exposure to escalating doses (0, 25, 50, and 100 mg/kg bw/day). The hepatotoxicity was evidenced by a significant elevation in liver enzymes (ALT, AST), indicative of liver cell damage. Furthermore, biochemical analysis revealed heightened levels of oxidative stress indicators (SOD, MDA, GSH) and the upregulation of endoplasmic reticulum stress proteins, underscoring the cellular stress response. The induction of hepatocyte apoptosis served as a direct marker of liver damage caused by glycidol exposure. Additionally, glycidol altered the composition of intestinal microbiota and short-chain fatty acids (SCFAs), which unbalanced homeostasis. Gut barrier integrity markers (ZO-1, Claudin-1, Occludin, TLR4, LPS) indicated increased permeability of harmful substances to the liver via the gut-liver axis, which exacerbated hepatic injury. These findings highlight glycidol's disruption of gut homeostasis and its hepatotoxic potential.
研究领域:
毒理学
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肝病学
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微生物学
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分子生物学
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DOI
高影响因子
Food Bioscience
·
2026
·
IF 6.2
Yuan Yuan,Yihui Wang,Lu Li,Qingyan Liu,Don Kulasiri,Haiyang Yan
Glycidol (GLD) is a common hazardous contaminant generated during thermal food processing, with well-documented genotoxicity and potential carcinogenicity. GLD is found in many processed foods, such as milk powder, potato chips, and coffee, as a result of the degradation of glyceryl esters (GEs) during heating. In this study, a Balb/c mouse model was used to evaluate the effects of GLD at different doses on neural homeostasis. Exposure to GLD led to reduced weight gain and metabolic disorders in mice. Behavioral assessments further revealed impairments in spatial learning and memory, as well as motor coordination. The in vitro cell model demonstrated that GLD significantly altered the expression of ferroptosis-specific proteins (Nrf2, GPX4, ACSL4), leading to the accumulation of reactive oxygen species (ROS), the inhibition of antioxidant enzyme (SOD, CAT, GSH) activity, and the increase in the level of malondialdehyde (MDA). In addition, GLD induced ferroptosis in brain tissue by inhibiting the Nrf2/GPX4 pathway, disrupting the expression of tight junction proteins (ZO-1, occludin), which in turn increased blood-brain barrier (BBB) permeability. Concurrently, GLD exposure elevated the release of inflammatory factors such as TNF-α and IL-6. Collectively, this study reveals a new mechanism by which GLD impairs BBB function and induces neurobehavioral disorders through ferroptosis, oxidative stress, and neuroinflammation, providing a new avenue for assessing the neurotoxicity by food processing byproducts.
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高影响因子
Carbon Letters
·
2025
·
IF 5.8
Deng Pengfei,Wang Shuangquan,Zhang Qiuxue,Li Songsong,Deng Yunjiao,Fu Zhongyu,Zhou Chao,Zhang Huixuan
Poor bonding occurs with resin due to surface inertness of carbon fiber (CF), so CF surfaces were often treated. In some common surface treatments, sizing was a simple and effective modification method. Polyurethane (PU) was used as the main component of sizing agents due to its similar structure to polyamide 6 (PA6). The CF/PA6 composites’ interfacial properties were improved using PU as a sizing agent. Meanwhile, in this paper, glycidol (GLD) was introduced into the PU emulsion so that the epoxy group reacted with the carboxyl group on the acidified CF. After testing, when the content of glycidyl in the sizing agent is 2%, the CF/PA6 composites showed an important improvement in tensile, impact, and flexural strengths, which increased by 49.4%, 94.6%, and 53.2%, respectively. In addition, the effect of modified WPU sizing agents with different GLD contents on the properties of CF/PA6 composites was investigated.
研究领域:
材料科学
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高分子科学
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复合材料
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表面改性
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化学工程
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DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
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2022
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IF 16.744
Huajun Wang,Tingting Liu,Chenyang Jiang,Yidan Wang,Jingjing Ma
A series of deep-eutectic solvents (DESs) with potassium hydroxide as hydrogen bonding acceptor and monoethanolamine (MEA) or polyethylene glycol (PEG) as hydrogen bonding donor were prepared and used as catalyst for the synthesis of glycidol and glycerol carbonate from glycerol and dimethyl carbonate. The effect of reaction parameter (reaction temperature, dimethyl carbonate/glycerol molar ratio, catalyst amount and reaction time) on the reaction was investigated in detail. It is found that the activity of KOH:MEA DES catalyst is related with its basicity. The KOH:MEA(1:2) exhibits higher catalytic activity, which may be due to the strong hydrogen bonding action between KOH:MEA(1:2) and reactants. The reaction kinetics model is also established and the reaction rate constant and active energy for each reaction are obtained by fitting the experimental data. The component concentration calculated by the kinetics model is close to the one of the experimental value.
研究领域:
化学工程
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催化
·
有机化学
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DOI
高影响因子
Polymers
·
2023
·Vol. 15
·期 2
·459
·
IF 5
Yunlong Le,Yunshan Guan,Xiaoying Ma,Weidong Zhang
Boron removal from aqueous solutions has attracted increasing attention, offering benefits for animal and plant health as well as profound significance for exploiting Salt Lake boron resources. In this work, we synthesized novel glycidol-functionalized and hydrophilic polyaniline (PANI) nanorod adsorbents, which were prepared to separate boron compounds from boric acid aqueous solutions. The as-prepared adsorbents were significantly different from the traditional polymers’ grafting reaction because they had a higher functional yield and more active position for adsorption. The maximum adsorption capacity (0.2210 mmoL∙g−1) and optimal adsorption conditions (boric acid concentration of 1307 mg/L, pH = 9.82, time of 10 h) were obtained with single-factor experimentation and the response surface method (RSM). In addition, adsorption kinetics studies showed that the adsorption reaction belonged to the pseudo-first-order kinetic model, and diffusion was the key limiting factor; therefore, the adsorption equilibrium time is more than 10 h. Finally, the related possible adsorption mechanism was investigated based on the species and the diffusion of boron in the aqueous phase.Keywords:boron adsorption;adsorbents;polyaniline nanorods;glycidol
研究领域:
环境科学
·
材料科学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF THE CHINESE CHEMICAL SOCIETY
·
2022
·Vol. 69
·期 3
·486-496
·
IF 1.753
Xiao-Ye Zhan,Bin Wang,Li-Ping Yu
Glycidol-modified polyethylenimine (PEI-OH)-capped carbon dots (PEI-OH-CDs) were prepared and applied for selectively and sensitively detecting folic acid in food samples. PEI-OH-CDs were firstly synthesized by a one-pot hydrothermal method using PEI-OH and citric acid as precursors, and the transmission electron microscopy characterization reveals that the PEI-OH-CDs were of spherical shape with diameters of 2–3 nm and well dispersed in solution. The PEI-OH-CDs have high fluorescence and exhibit ultrastrong stability against pH, ion strength, and UV light irradiation. In a wide pH range higher than pH 6, the fluorescence of PEI-OH-CDs can be effectively quenched by folic acid through static quenching process and inner filter effect but is not affected by many typical chemicals including cations, anions, amino acids, and vitamins. A good linear relationship was found between the F 0 /F and the concentration of folic acid in the range from 0.1 to 100 μM, and the detection limit of folic acid is 0.07 μM. The PEI-OH-CDs were successfully applied for sensitive determination of folic acid in orange juice, fresh pear, grape spinach, and celery samples at pH 7.2, which is helpful to the stability of folic acid and provides a new strategy for accuracy detection of folic acid in food samples.
研究领域:
分析化学
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食品科学
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生物医学
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DOI
高影响因子
JOURNAL OF MOLECULAR LIQUIDS
·
2023
·
IF 6
Ding Jiang,Yuting He,Jinrui Zhang,Jie Yin,Jing Ding,Shuang Wang,Hongping Li
Conjugate acid-base bi-functional PILs (CAB-PILs) with carboxylate and carboxyl branches were synthesized and used as catalysts for the cycloaddition reaction of glycidol with CO 2 . Two functional ionic monomers, 3-(carboxymethyl)-1-vinyl-1H-imidazol-3-ium chloride (CEImCl) and 2-(1-vinyl-1H-imidazol-3-ium-3-yl) acetate (CCIm), were introduced into the CAB-PILs skeleton. In this case, we proved the excellent characteristics of the catalyst containing both Lewis base and Bronsted acid sites for converting CO 2 to cyclic carbonate under mild conditions. The catalyst showed good reusability and remained excellent activity after five reaction cycles. Combined with XPS, FTIR and DFT calculations, it is proved that the CCIm ionic monomer not only play the role of CO 2 absorption center, but also has synergistic effect with CEImCl in CAB-PILs to promote cycloaddition reaction.
研究领域:
化学工程
·
催化材料科学
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产品关联
DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2026
·
IF 9.1
Huajun Wang,Yan Li,Tengfei Wang,Xirui Zhang
A new method for direct synthesis of glycidol from glycerol and propylene carbonate is reported that may be promising and economically valuable. In traditional reactors, under atmospheric pressure and without catalyst, the reaction between glycerol and propylene carbonate can only produce small amount of glycerol carbonate, but almost no glycidol is produced. Here, it is surprisingly found that under vacuum condition, glycidol can be obtained directly from glycerol and propylene carbonate by vacuum reaction distillation (VRD). Based on the above findings, the direct synthesis of glycidol from glycerol and propylene carbonate by VRD without any catalyst or solvent is investigated by the systematic experiment and process simulation. The experiment results indicate that at reflux ratio of about 1, molar ratio of propylene carbonate to glycerol of 2, bottom temperature of 190 °C, and column height of 400 mm, the glycerol conversion and glycidol yield can reach 98.9% and 61.5%, respectively. After purification, the mass fraction of glycidol in distillate can reach 98.9%. Furthermore, based on the study on reaction kinetics and residual curve analysis for the reaction system, the above VRD process is further simulated and optimized by using Aspen plus software and the optimized process flowsheet is obtained. Finally, a technical and economic analysis of the entire process is carried out.
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DOI
高影响因子
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