Novel approach to the synthesis of istaroxime
Istaroxime 1 , a novel cardiotonic agent with high efficiency and low toxicity was synthesized from dehydroepiandrosterone 2 using a novel approach that included epoxidation, ring-opening, substitution, and oximation. The new protocol without gas protection was milder than the reported approaches. The overall yield of the method was 24.1%.
研究领域:
药物化学
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有机合成
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）