Journal of Materials Chemistry B
·
2019
·Vol. 7
·期 26
·4153-4160
·
IF 5.047
Qi-Bao Yan,Ning Bao,Shou-Nian Ding
The poor stability of fully inorganic halide perovskite nanocrystals (PNCs) has always restricted their wider application, especially in cell imaging. It has attracted more and more attention to use ligand engineering to improve the stability of PNCs. In this work, CsPbBr3/mPEG-NH2 NCs were synthesized using a highly biocompatible functional polymer, methoxypolyethylene glycol amine, as the capping ligand. The as-prepared CsPbBr3/mPEG-NH2 NCs exhibited superior water solubility as a result of the hydrophilic properties of mPEG-NH2. More shockingly, a significantly enhanced fluorescence intensity was found when CsPbBr3/mPEG-NH2 NCs were dispersed in water for a period of time. Correspondingly, the fluorescence quantum yield increased from the initial 16% to 41% a week later. Meanwhile, the thermal stability of the product has been greatly improved; about 80% of the initial PL intensity was still maintained after heating the product to 100 °C. Finally, we directly utilized the CsPbBr3/mPEG-NH2 NCs as luminescent probes for cell imaging for the first time.
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DOI
高影响因子
JOURNAL OF LUMINESCENCE
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2026
·
IF 3.8
Jingran Zhang,LiYan Zheng,Guifu Zuo,Yuchen Yue,Qian Zhang,Mengnan Zhang
Lead-free copper halides have emerged as promising self-trapped exciton (STE) emitters for broadband white-light generation, yet the direct construction of compositionally regulated single-matrix white emitters remains challenging. This study presents an mPEG-NH 2 -directed phase-engineering strategy for the one-step in situ construction of biphasic Cs 3 Cu 2 I 5 /CsCu 2 I 3 copper halides. By introducing methoxy polyethylene glycol amine into the ligand-assisted reprecipitation (LARP) process, the local coordination environment and supersaturation-driven nucleation behavior of Cs + , Cu + , and I − species are regulated, enabling the coexistence of blue-emitting Cs 3 Cu 2 I 5 and yellow-emitting CsCu 2 I 3 within one crystallization system. The amino and ether oxygen sites of mPEG-NH 2 further promote interfacial coupling with the copper halide matrix, reducing non-radiative STE deactivation and improving radiative recombination. The optimized CCI:3P sample exhibits broadband white-light emission with Commission Internationale de l’Éclairage (CIE) coordinates of (0.3236, 0.3347), a photoluminescence (PL) quantum yield of 42.8%, and a prolonged exciton lifetime. A UV-pumped WLED based on CCI:3P emits white light with a correlated color temperature of 6052 K. In addition, the biphasic material exhibits distinct water- and heat-induced luminescence changes, demonstrating stimulus-dependent optical contrast. This work provides a polymer-directed strategy for designing lead-free copper halide emitters with integrated white-light emission and responsive optical functionality.
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DOI
高影响因子
REACTIVE & FUNCTIONAL POLYMERS
·
2019
·
IF 3.074
Chuang Zhou,Ziming Yang,Li Zhang,Enming Dong,Zuyu He,Xianwu Liu,Chao Wang,Yan Yang,Jing Jiao,Yunhao Liu,Yu Chen,Puwang Li
In this work, carboxymethyl chitosan-graft-eleostearic acid (CMCS-g-EA) was synthesized via the amide reaction between the amino groups of carboxymethyl chitosan and the carboxyl group of eleostearic acid, and then mPEG-NH 2 was grafted to CMCS-g-EA to prepare amphiphilic polymers (mPEG-CMCS-g-EA). The chemical structures of the above conjugates were characterized by FT-IR and 1 H NMR. Both CMCS-g-EA and mPEG-CMCS-g-EA based nano-vesicles were prepared by ultrasonic self-assembly method and they exhibited a low critical aggregation concentration (CAC) of 14.97 μg/mL, 16.82 μg/mL, respectively. The spinosad-loaded mPEG-CMCS-g-EA nano-vesicles (SSD@mPEG-CMCS-g-EA NVs) were spherical in shape with an average diameter of 502.8 nm and the zeta potential of −25.60 mV. The encapsulation efficiency (EE) and drug loading content (LC) of SSD@mPEG-CMCS-g-EA nano-vesicles were 42.00%, 23.07%, respectively. In vitro release revealed that the SSD@mPEG-CMCS-g-EA nano-vesicles exhibited a sustained and pH-responsive drug release property, and could significantly enhance the photostability of spinosad . Furthermore, the toxicological tests demonstrated that the SSD@mPEG-CMCS-g-EA nano-vesicles could efficiently inhibit the growth and development of Helicoverpa armigera . These results indicated that the SSD@mPEG-CMCS-g-EA nano-vesicles were highly potential for the treatment of Helicoverpa armigera .
研究领域:
农药科学
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生物材料学
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昆虫学
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DOI
高影响因子
Discover Nano
·
2023
·Vol. 18
·期 1
·1-14
·
IF 0
Shao Runrun,Qiao Xiaofang,Cao Linlin,Man Jianliang,Guo Lingyun,Li Lanlan,Liu Wen,Li Lihong,Wang Bin,Guo Lixia,Ma Sufang,Zhang Boye,Wang Haojiang,Yan Lili
The development of nanoparticles capable of inducing reactive oxygen species (ROS) formation has become an important strategy for cancer therapy. Simultaneously, the preparation of multifunctional nanoparticles that respond to the tumor microenvironment is crucial for the diagnosis and treatment of tumors. In this study, we designed a Molybdenum disulfide (MoS 2 ) core coated with Manganese dioxide (MnO 2 ), which possessed a good photothermal effect and could produce Fenton-like Mn 2+ in response to highly expressed glutathione (GSH) in the tumor microenvironment, thereby generating a chemodynamic therapy (CDT). The nanoparticles were further modified with Methoxypoly(Ethylene Glycol) 2000 (mPEG-NH 2 ) to improve their biocompatibility, resulting in the formation of MoS 2 @MnO 2 -PEG. These nanoparticles were shown to possess significant Magnetic Resonance Imaging (MRI) and Computed Tomography (CT) imaging capabilities, making them useful in tumor diagnosis. In vitro and in vivo experiments demonstrated the antitumor ability of MoS 2 @MnO 2 -PEG, with a significant killing effect on tumor cells under combined treatment. These nanoparticles hold great potential for CDT/photothermal therapy (PTT) combined antitumor therapy and could be further explored in biomedical research.
研究领域:
生物医学工程
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纳米技术
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癌症治疗
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医学成像
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DOI
CHEMICAL ENGINEERING JOURNAL
·
2021
·
IF 13.273
Jian-Jiang Lu,Qi Shen,Xiao-Ying Li,Fei-Yun Sun,Jun-Bo Yi,Wen-Yi Dong,Wei-Jia Yan,Hong Du,Jia-Le Mu
Undesired long start-up time and unstable denitrification performance are major bottlenecks for engineering application of methane-based membrane biofilm reactors (MBfRs). In this study, two surface-manipulated membranes by respectively coating dopamine (DOPA) and grafting methoxy-poly(ethyleneglycol)-amine (mPEG-NH 2 ) onto the base polypropylene (PP) membrane were prepared, and for the first employed to aerobic methane oxidation coupled to denitrification (AME-D) process in MBfRs for quick biofilm formation and improving denitrification performance. The experiments demonstrated that the modified membranes, especially for PP/DOPA/mPEGNH 2 membrane, accelerated biofilm formation, and then shorten above 31% start-up time compared to the base PP membrane. Meanwhile, the biofilm detachment resistances also improved in the MBfRs employing the modified membrane. Extended Deraguin-Landau-Verwery-Oxerbeek (XDLVO) theory analysis indicated these benefits mainly attribute to enhanced interfacial interaction energy, which is significant to microbial initial attachment onto membrane surface. 16S rRNA gene analysis demonstrated the modified membrane also preferentially increased the abundances of key microorganisms at initial stage. These findings revealed the importance of quick biofilm formation and robust detachment resistance by involving surface-manipulated membranes onto maintaining MBfRs efficiency and stability.
研究领域:
环境工程
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微生物学
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生物技术
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DOI
高影响因子
Pharmaceutics
·
2024
·Vol. 16
·期 9
·1178
·
IF 4.9
Xiao Duan,Qiang Wang,Yue Wang,Xinping Liu,Manman Lu,Zhifang Li,Xuelian Jiang,Jingquan Ji
Using an endogenous carrier is the best method to address the biocompatibility of carriers in the drug delivery field. Herein, we prepared a glutathione-responsive paclitaxel prodrug micelle based on an endogenous molecule of L-glutathione oxidized (GSSG) for cancer therapy using one-pot synthesis. The carboxyl groups in L-glutathione oxidized were reacted with the hydroxyl group in paclitaxel (PTX) using the catalysts dicyclohexylcarbodiimide (DCC) and 4-dimethylaminopyridine (DMAP). Then, the amino-polyethylene glycol monomethyl ether (mPEG-NH2) was conjugated with GSSG to prepare PTX-GSSG-PEG. The structure of PTX-GSSG-PEG was characterized using infrared spectroscopy (FT-IR), nuclear magnetic resonance spectroscopy (NMR), and mass spectrometry (MS). The drug release kinetics of PTX within PTX-GSSG-PEG were quantified using ultraviolet spectroscopy (UV-Vis). The size of the PTX-GSSG-PEG micelles was 83 nm, as evaluated using dynamic light scattering (DLS), and their particle size remained stable in a pH 7.4 PBS for 7 days. Moreover, the micelles could responsively degrade and release PTX in a reduced glutathione environment. The drug loading of PTX in PTX-GSSG-PEG was 13%, as determined using NMR. Furthermore, the cumulative drug release rate of PTX from the micelles reached 72.1% in a reduced glutathione environment of 5 mg/mL at 120 h. Cell viability experiments demonstrated that the PTX-GSSG-PEG micelles could induce the apoptosis of MCF-7 cells. Additionally, cell uptake showed that the micelles could distribute to the cell nuclei within 7 h. To sum up, with this glutathione-responsive paclitaxel prodrug micelle based on the endogenous molecule GSSG, it may be possible to develop novel nanomedicines in the future.
研究领域:
药学
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纳米技术
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癌症研究
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药物递送系统
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材料科学
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）