A Novel and Efficient Synthesis of Anti-Cancer Agent, Mereletinib
A convenient route for the synthesis of a third-generation epidermal growth factor receptor inhibitor, mereletinib (AZD9291) using starting materials that are commercially available has been achieved through reactions that are readily conducted under mild conditions. Importantly, a 5 g scale synthesis was also accomplished and this method could therefore be useful in the synthesis of similar drugs.
研究领域:
药物化学
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有机合成
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肿瘤学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）