JOURNAL OF NANOPARTICLE RESEARCH
·
2021
·Vol. 23
·期 5
·1-14
·
IF 2.253
Zhu Li,Song Zhimei,Feng Sijia,Xu Hongmei,Chen Shiyu,Feng Runliang
In the study, biotin-modified oligochitosan-F127 conjugate (F127-CS-BIO) was synthesized as a carrier to prepare honokiol-loaded micelles via dialysis method. The encapsulation efficiency and drug loading were 70.79 ± 2.70% and 9.70 ± 0.57%, respectively. The mean particle size and zeta potentials were 210.9 ± 4.65 nm and 12.9 ± 7.22 mV, respectively. In vitro release studies showed that the release of honokiol from the micelles was slow and steady. MTT evaluation and cellular uptake results demonstrated that F127-CS-BIO was more easily absorbed by tumor cells and resulted in low IC 50 value of honokiol due to biotin’s targeting guidance when compared with biotin-unmodified F127-CS. In conclusion, F127-CS-BIO polymer was expected as an effective nanocarrier to encapsulate chemotherapeutic drugs. Graphical abstract
研究领域:
药剂学
·
纳米医学
·
肿瘤学
✓ 已验证
产品关联
DOI
高影响因子
COLLOID AND POLYMER SCIENCE
·
2019
·Vol. 297
·期 2
·225-238
·
IF 1.906
Zhang Longshuai,Liu Yuancheng,Zhang Kui,Chen Yuanwei,Luo Xianglin
Redox-responsive block copolymer micelles have been studied extensively as drug carriers. In this study, tri-block copolymers, methoxyl poly(ethylene glycol)-b-poly(ε-caprolactone)-SeSe-b-poly(ε-caprolactone)-b-methoxyl-poly(ethylene glycol) (mPEG-PCL-SeSe-PCL-mPEG) and methoxyl poly(ethyleneglyco)-b-poly(ε-caprolactone)-SS-b- poly(ε-caprolactone)-b-methoxyl-poly(ethylene glycol) (mPEG-PCL-SS-PCL-mPEG), were synthesized to investigate the redox sensitivity differences between diselenide and disulfide micelles. The changes of micelles in size and structure were investigated under conditions with glutathione (GSH) or H 2 O 2 . The results showed that the size and PDI of (mPEG-PCL-Se) 2 micelles presented more significant variations under redox condition in comparison with (mPEG-PCL-S) 2 micelles. The DOX released faster and more from diselenide micelles than disulfide micelles. The half maximal inhibitory concentration (IC 50 ) of (mPEG-PCL-Se) 2 /DOX micelles was lower than that of (mPEG-PCL-S) 2 /DOX micelles against 4T1 and Hela cells. The amount of intracellular drug release from diselenide micelles was higher than from disulfide micelles in Hela cells with GSH 4.6 mM. Therefore, the (mPEG-PCL-Se) 2 micelles similar to (mPEG-PCL-S) 2 micelles are stimuli-responsive and may be more sensitive drug carriers.
The polymer micelles containing diselenide or disulfide with similar molecular structure are prepared to investigate the redox sensitivity differences. Both micelles have redox sensitivity and capability to enter into 4T1 cells and Hela cells. (mPEG-PCL-Se) 2 micelles present more significant sensitivity and lower IC 50 against cancer cells than disulfide micelles. The diselenide micelles may be more sensitive platforms and be suit to tumor cells in which GSH is less than 10 mM.
研究领域:
药学
·
生物化学
·
材料科学
✓ 已验证
DOI
高影响因子
JOURNAL OF MOLECULAR LIQUIDS
·
2022
·
IF 6.633
Rui Qi,Baohua Liu,Hongmei Li,Jian Wang,Xiaohong Li,Yong Jin,Songzhi Xie
Controlling the shape and size of the nanomicelles attracts great interest and is still challenging. Herein, we synthesized a kind of diblock copolymers with the hydrophilic block (poly (ethylene glycol) methyl ether, PEG) and the core-forming block composed alternately by hydrophobic segments, hydrogen-bonding carbamates and pH-responsive groups. The synergy effect of the pH variation and the core-forming block length on the morphologies of the assemblies was well studied. Ultrathin scarf-like micelles, ultrathin disk-like micelles and spherical micelles were obtained by tailoring the pH values and the lengths of the core-forming blocks. The ultrathin scarf-like micelles and ultrathin disk-like micelles were proved to be composed of a lamellar bimolecular layer of the block copolymers. This study will supply an effective method to fabricate well-defined nanostructures.
研究领域:
高分子化学
·
纳米材料科学
✓ 已验证
DOI
高影响因子
Soft Matter
·
2012
·Vol. 8
·期 30
·7858-7864
·
IF 4.39
Jun Li,Mingwei Zhao,Hongtao Zhou,Hejun Gao,Liqiang Zheng
A photo-responsive system composed of an imidazolium-type surfactant 1-hexadecyl-3-methylimidazolium bromide ([C16mim]Br) and a commonly photosensitive aromatic compound trans-cinnamic acid (trans-CA) was studied through UV spectra, 1H NMR, and rheological measurements. In aqueous solution, the compounds [C16mim]Br and trans-CA can self-assemble to form viscoelastic wormlike micelles. Through UV irradiation, the CA molecules exhibit molecular photoisomerization from trans- to cis-, which results in a change of the molecular critical packing. The wormlike micelles transform into spherical micelles after UV irradiation, which is also confirmed by rheological measurements.
研究领域:
胶体化学
·
软物质物理
·
药物递送
·
分子自组装
·
光响应材料
✓ 已验证
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2021
·
IF 6.953
Xiaohong Liu,Hui Zhang,Juanli Shen,Bingyun Li,Shiyu Fu
Recently, cellulose-based stimuli-responsive nanomaterials have received significant attention because of its natural source and biocompatibility. In this study, cellulose-graft-poly(nisopropylacrylamide)-co-2-methyl-acrylic acid 2-carbazol-9-yl-ethyl ester (cellulose-g-(PNIPAAm&PCz)) block polymers were successfully synthesized by homogeneous atom transfer radical polymerization (ATRP) in LiCl/ N , N -dimethylacetamide (DMAc) dissolution system. The block polymers showed different properties due to the different PCz content. The block polymer with low PCz content (cellulose-g-(PNIPAAm&PCz)1) was dispersed in water at 25 °C and self-assembled into micelles at 37 °C. On the other hand, the block polymer with high PCz content (cellulose-g-(PNIPAAm&PCz)2) was dissolved in DMF, THF, DMSO firstly, and dialyzed at 25 °C, 37 °C and 60 °C respectively to obtain the micelles. Transmission electron microscopy (TEM) and dynamic light scattering (DLS) indicated that the distribution range of micelles formed by cellulose-g-(PNIPAAm&PCz)1 was narrower than cellulose-g-(PNIPAAm&PCz)2. And the sizes of the micelles formed by cellulose-g-(PNIPAAm&PCz)2 had little difference under different solvents, but became bigger with the temperature increased. The micelles displayed thermo-enhanced fluorescence due to the thermal-driven chain dehydration of the grafted PNIPAAm brushes, which is contrary to the decrease of the fluorescence of the monomer when the temperature increased. The results provided a potential for the application of cellulose-based stimuli-responsive micelles in the field of drug delivery and fluorescent probes .
研究领域:
材料科学
·
生物医学工程
·
高分子化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
·
2022
·
IF 5.062
Jiarong Hang,Yu Chen,Pengyao Tian,Ruonan Yu,Miao Wang,Min Zhao
Niclosamide (NIC) has been found to have outstanding antitumour activity in recent years, but its clinical application has been limited by its poor water solubility. In this study, nanomicelles (PEG 2K -Fmoc-Ibuprofen micelles , PEG 2K -FIbu) were prepared as carriers to improve the solubility and bioavailability of NIC. Nuclear magnetic resonance (NMR) confirmed its successful preparation. The drug-carrying micelles (PEG 2K -FIbu/NIC) were then prepared using a thin film dispersion method. PEG 2K -FIbu and PEG 2K -FIbu/NIC were analysed in detail in terms of particle size, polymer dispersion index, stability and encapsulation efficiency. Finally, the in vivo effects of PEG 2K -FIbu/NIC were tested in a mouse liver cancer model. The particle size of PEG 2K -FIbu was 11.11 nm. The encapsulation rate was 70.4% and the tumour inhibition rate was 55.98%. Tumours were significantly reduced and damage to the liver was greatly reduced. The histopathological sections and serum biochemical indices also showed that the symptoms were significantly improved after administration. In summary, PEG 2K -FIbu/NIC is a potential drug delivery system of NIC to effectively treat liver cancer, providing an effective dosage form for NIC.
研究领域:
药学
·
癌症研究
·
药物递送系统
·
纳米技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Biomaterials Science & Engineering
·
2019
·
IF 4.511
Quan Wang,Dongqin Lei,Fan Chen,Yuanwei Chen,Xianglin Luo
Although smart polymer micelles able to respond to the tumor acid microenvironment are potential anticancer drug carriers, fruitful clinical application of these carriers is inadequate. For the purpose of finding the origin of the unsatisfactory therapeutic efficacy of pH-sensitive drug carriers with tertiary amine groups, we newly designed and synthesized poly{α-[4-(diethylamino)methyl-1,2,3-triazol]-caprolactone-co-caprolactone}-b-poly(2-methacryloyloxyethyl phosphorylcholine) (PDCL-PMPC), a biomimetic phosphorylcholine polymer with pH-ensitive groups. PDCL-PMPC self-assembles into small and uniform micelles as its counterpart poly(caprolactone)-b-poly(2-methacryloyloxyethyl phosphorylcholine) (PCL-PMPC) without pH-sensitive groups. The in vitro and in vivo properties of PDCL-PMPC and PCL-PMPC micelles are investigated in detail. PDCL-PMPC micelles display obvious pH sensitivity by micelle change and fast drug release at pH 5, but the insensitive micelles do not. The internalization of PDCL-PMPC micelles by tumor cells is stronger than that of PCL-PMPC micelles. However, in comparison with the insensitive micelles, the pH-sensitive micelles present much shorter blood circulation time in pharmacokinetics and demonstrate worse accumulation in the tumor site in vivo study. As a result, DOX loaded PCL-PMPC micelles demonstrate much better antitumor efficiency than pH-sensitive micelles. Furthermore, DOX loaded PCL-PMPC micelles show similar therapeutic efficacy to DOX·HCl but with considerably lower side effects.
研究领域:
药剂学
·
肿瘤学
·
生物材料学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Biomedical Nanotechnology
·
2020
·Vol. 16
·期 10
·1463-1470
·
IF 4.483
Ding Xiangyu,Wang Yuan,Wen Chunmei,Wang Silu,Ruan Qingqing,Li Zhaofeng,Xu Jinzhong,Xu Zheng,Deng Jie
Rhein is a potential anti-inflammatory agent, but its poor water solubility significantly restricts its clinical application. In this study, rhein micelles (RMs) with improved water solubility were fabricated on Pluronic F127 (F-127). Transmission electron microscopy showed that the
as-prepared RMs displayed a mean diameter of approximately 20 nm and a spherical morphology. The encapsulation efficiency of the micelles towards drugs varied from 81.38 ± 4.35% to 24.87 ± 4.32%. The RMs exhibited a burst release during the first 6 h and a following sustained
release up to 96 h with a biphasic drug release pattern as suggested by the drug release assay. Cytotoxicity assessment showed that the RMs caused no change in cell viability at drug concentrations below 40 μM after 24 and 48 h of incubation. In RAW264.7 macrophages, the RMs inhibited the
lipopolysaccharide-induced activation of p65/NF-κB, which in turn suppressed the transcription of its downstream inducible nitric oxide synthase, and cytokine genes such as interleukin-1β and tumor necrosis factor-α . Simultaneously, the RMs led to reduced cytokine secretions,
including cyclooxygenase-2, prostaglandin E2, nitric oxide, and interleukin-6 in a dose-dependent manner. The RMs reported herein may be a promising candidate for developing anti-inflammatory therapeutic formulations.
研究领域:
药学
·
纳米技术
·
炎症研究
✓ 已验证
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2025
·
IF 5.4
Yucheng Sun,Longyu Tian,Zaijun Lu
This study developed unimolecular micelles featuring a polyhedral oligomeric silsesquioxane (POSS) core and eight arms by reacting POSS with the block copolymer mPEG- b -PCL, which were utilized as a drug delivery platform. Compared to conventional self-assembled polymeric micelles, POSS unimolecular micelles exhibit precise dimensions and are monodisperse. They lack a critical micelle concentration (CMC) and can maintain stability in physiological environments with varying concentrations and pH levels. The POSS unimolecular micelles are constructed using biocompatible materials, specifically polycaprolactone and polyethylene glycol. POSS features a rigid cage-like structure along with multifunctional group characteristics, which serve as a stable core for unimolecular micelles. This significantly enhances both the drug-loading capacity and thermodynamic stability of the micelles, rendering them suitable for applications in physiological environments. POSS unimolecular micelles can encapsulate the anticancer drug doxorubicin, offering enhanced stability and prolonged drug release time compared to conventional polymer micelles, thereby providing a sustained-release effect.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF WUHAN UNIVERSITY OF TECHNOLOGY-MATERIALS SCIENCE EDITION
·
2018
·Vol. 33
·期 1
·221-225
·
IF 0.524
Zhu Saisai,Zhu Hui,Xia Ru,Feng Xiaoshuang,Chen Peng,Qian Jiasheng,Cao Ming,Yang Bin,Miao Jibin,Su Lifen,Song Changjiang
Diblock copolymers polystyrene-block-polyvinyltriethoxysilane (PS-b-PVTES) were synthesized via atom transfer radical polymerization (ATRP), which self-assembled into spherical micelles in solvent of THF-methanol mixtures. The self-assembled micelles were immobilized by cross-linking reaction of VTES in a shell layer of micelles. The chemical structures of block copolymers and morphology of micelles were characterized in detail. It was found that the size of immobilized micelles was strongly affected by the copolymer concentration, composition of mixture solvent, and block ratios.
研究领域:
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
LANGMUIR
·
2017
·
IF 3.833
Mingwei Zhao,Mingwei Gao,Caili Dai,Chenwei Zou,Zhe Yang,Xuepeng Wu,Yifei Liu,Yining Wu,Sisi Fang,Wenjiao Lv
Smart wormlike micelles with stimuli-tunable rheological properties may be useful in a variety of applications, such as in molecular devices and sensors. The formation of triplestimuli-responsive systems so far has been a challenging and important issue. In this work, a novel triplestimuli (photo-, pH-, and thermoresponsive) wormlike micelle is constructed with N-cetyl-N-methylmorpholinium bromide and trans-cinnamic acid (CA). The corresponding multiresponsive behaviors of wormlike micellar system were revealed using cryogenic transmission electron microscopy, a rheometer, and 1H NMR. The rheological properties of wormlike micellar system under different temperatures, pH conditions, and UV irradiation times are measured. As confirmed by 1H NMR, chemical structure of a CA molecule can be altered by the multiple stimulation from an exotic environment. We expect it to be a good model for triple-responsive wormlike micelles, which is helpful to understand the mechanism of triple-responsiveness and widen their applications.
研究领域:
化学
·
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF CONTROLLED RELEASE
·
2023
·
IF 10.8
Quan Wang,Yi Duan,Hongshu Jing,Zhihua Wu,Yu Tian,Ke Gong,Qianqian Guo,Jiali Zhang,Ying Sun,Zhaojun Li,Yourong Duan
Atherosclerosis is a chronic disease initiated by lipid-mediated vascular inflammation . From the perspective of conventional treatment, it is difficult to achieve good therapeutic effects via regulation of a single lipid or anti-inflammatory effects. Herein, we designed an amphiphilic low molecular weight heparin-unsaturated fatty acid conjugate (LMWH-uFA) that acted as both an antiatherosclerotic agent and a nanocarrier with self-delivery properties. Structurally, LMWH-uFA self-assembled to form micelles with LMWH as the shell and uFA as the core, without any additives, which guaranteed their biosafety. Functionally, the hydrophilic segment, LMWH, prevented monocyte adhesion to inhibit early vascular inflammation, and the hydrophobic segment, uFA, could participate in the regulation of blood lipids. The anti-inflammatory drug rapamycin (RAP) was encapsulated in the micellar core, which improved its water solubility, and cooperated with LMWH to achieve targeted blockade of the vascular inflammation cascade at P-selectin. The three treatment modules, LMWH, uFA and RAP, were integrated into one system for different therapeutic targets in anticipation of better efficacy. In an atherosclerosis mouse model, RAP-loaded NPs significantly reduced the plaque area and showed satisfactory curative effects, which were related to the targeting of lipid regulation and inflammation. Thus, these modular micellar nanoparticles offer a promising approach for the clinical treatment of atherosclerosis.
研究领域:
药理学
·
纳米医学
·
心血管疾病
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）