查找使用阿拉丁产品的科研文献

Drp1 Aggravates Copper Nanoparticle-Induced ER-Phagy by Disturbing Mitochondria-Associated Membranes in Chicken Hepatocytes

Quanwei Li,Pan Guo,Shaofeng Wang,Luna Su,Wenlan Yu,Jianying Guo,Liammei Hu,Hui Zhang,Jiaqiang Pan,Zhaoxin Tang,Jianzhao Liao

As an efficient alternative copper (Cu) source, copper nanoparticles (nano-Cu) have been widely supplemented into animal-producing food. Therefore, it is necessary to assess the effect of nano-Cu exposure on the biological health risk. Recently, the toxic effects of nano-Cu have been confirmed but the underlying mechanism remains unclear. This study reveals the impact of nano-Cu on endoplasmic reticulum autophagy (ER-phagy) in chicken hepatocytes and further identifies Drp1 and its downstream gene FAM134B as crucial regulators of nano-Cu-induced hepatotoxicity. Nano-Cu exposure can induce Cu ion overaccumulation and pathological injury in the liver, trigger excessive mitochondrial fission and mitochondria-associated membrane (MAM) integrity damage, and activate ER-phagy in vivo and in vitro. Interestingly, the knockdown of Drp1 markedly decreases the expression of FAM134B induced by nano-Cu. Furthermore, the expression levels of ATL3, CCPG1, SEC62, TEX264, and LC3II/LC3I induced by nano-Cu exposure are decreased by inhibiting the expression of Drp1. Simultaneously, the inhibition of FAM134B effectively alleviates nano-Cu-induced ER-phagy by downregulating the expression of ATL3, CCPG1, SEC62, TEX264, and LC3II/LC3I. Overall, these results suggest that Drp1-mediated impairment of MAM integrity leads to ER-phagy as a novel molecular mechanism involved in the regulation of nano-Cu-induced hepatotoxicity. These findings provide new ideas for future research on the mechanism of nano-Cu-induced hepatotoxicity.

Preparation of PMMA/Nano-Cu Antibacterial Plastic by In Situ Polymerization

Xiao Chen,Hua Lei,Tao Xu,Jie Zhang,Yu Qiu,Lu Tan

PMMA/nanoCu antibacterial plastic was prepared by in situ polymerization using MMA as monomer, BPO as initiator and surface treated nanoCu as antibacterial agent. AMEO was used for surface treatment of nanoCu. ATR-FTIR spectra showed that AMEO successfully reacted on the surface of nanoCu. SEM spectra showed that nanoCu dispersed evenly in the PMMA/nanoCu composite. Antibacterial test results showed that the composite had a strong antibacterial effect on Escherichia coli, and the antibacterial rate reached more than 99%. Therefore, the PMMA/nanoCu composite can be used in various fields of antibacterial plastic products.

The Toxic Effects and Mechanisms of Nano-Cu on the Spleen of Rats

Xuerong Zhou,Ling Zhao,Jie Luo,Huaqiao Tang,Min Xu,Yanyan Wang,Xiaoyu Yang,Helin Chen,Yinglun Li,Gang Ye,Fei Shi,Cheng Lv,Bo Jing

Research has shown that nano-copper (nano-Cu) can cause damage to the spleen and immune system yet their mechanisms of cytotoxicity are poorly understood. Our aim is to explore the potential immunotoxicity in the spleen of rats after nano-Cu exposure. The results of hematologic parameters, lymphocyte subsets, immunoglobulins, and histopathology indicated that copper obviously changed the immune function of the spleen. The levels of antioxidants (SOD, CAT, GSH-Px), oxidants (iNOS, NO, MDA), and anti-oxidative signalling pathway of Nrf2 (Nrf2 and HO-1) were strongly induced by nano-Cu. The expression of mRNA and protein of pro-/anti-inflammatory (IFN-γ, TNF-α, MIP-1α, MCP-1, MIF, IL-1/-2/-4/-6) cytokines were increased by nano-Cu. The expression of regulatory signal pathways, MAPKs and PI3-K/Akt were activated, which might be involved in the inflammatory responses and immunomodulatory processes of sub-acute nano-Cu exposure. The immune function of the spleen was repressed by nano-Cu induced oxidative stress and inflammation.Keywords:nano-Cu;rats;spleen injury;immune system;oxidative stress

Highly efficient MXene/Nano-Cu smoke suppressant towards reducing fire hazards of thermoplastic polyurethane

Yongqian Shi,Chuan Liu,Libi Fu,Yuezhan Feng,Yuancai Lv,Zixiao Wang,Minghua Liu,Zhixin Chen

A large number of toxic fumes evolved from polymeric materials are a great threat to human evacuation. The aim of this work is to dramatically reduce the generation of smoke and toxic gaseous products upon polymers burning. A highly efficient titanium carbide/nano-copper (Ti 3 C 2 T x /Nano-Cu) hybrid smoke suppressant was synthesized by interficial adhesion and then incorporated into thermoplastic polyurethane (TPU) to fabricate TPU nanocomposites. The Ti 3 C 2 T x /Nano-Cu hybrid was homogeneously dispersed in the TPU matrix and showed a strong interfacial interaction with the TPU host. Introducing the Ti 3 C 2 T x /Nano-Cu hybrid into TPU led to enhanced high-temperature stability. Furthermore, the smoke production rate, CO production rate and total CO yield of the TPU nanocomposite containing 2 wt% Ti 3 C 2 T x /Nano-Cu hybrid decreased by 66.7%, 51.8% and 52.9%, respectively, compared with those of pure TPU. The reduced fire hazards of the TPU were due to the physical barrier, the catalytic charring and the chemical conversion of Ti 3 C 2 T x /Nano-Cu hybrid.

Fabrication and Sintering Behavior of Nano Cu–Ag Composite Paste for High-Power Device

Weishan Lv,Jiaxin Liu,Yun Mou,Yongjie Ding,Mingxiang Chen,Fulong Zhu

Superhydrophobicity-driven interfacial enrichment and SERS detection of PFOA on nano-Cu modified Ag foam

Xiaoya Yuan,Lei Ouyang,Zhou Song,Xuelin Dong,Zhenli Zhu,Qin Shuai,Shenghong Hu

Perfluoroalkyl and polyfluoroalkyl substances (PFAS) present a serious risk to ecosystems and human health, underscoring the need for highly sensitive detection methods. Existing analytical approaches often lack the portability and rapid response required for on-site screening, and conventional surface-enhanced Raman spectroscopy (SERS) substrates exhibit limited affinity toward hydrophobic PFAS molecules. To overcome these limitations, we designed a superhydrophobic nano-Cu modified Ag foam that integrates hydrophobic enrichment with specific metal-carboxylate coordination for effective perfluorooctanoic acid (PFOA) capture and detection. The critical role of Cu 2+ as a bridging site for selective PFOA adsorption was elucidated. This design achieves a remarkably low detection limit of 0.1 μg L −1 for PFOA and enables discrimination between different PFAS categories. Moreover, it maintains excellent SERS activity after two months of storage, effectively addressing the issue of facile oxidation of Cu. The substrate was successfully applied to detect PFOA in various real water samples, demonstrating its potential as a practical and powerful platform for environmental PFAS monitoring.

Piezo-Phototronic PVDF/HfO2/Nano-Cu Heterostructured Thin Film for Flexible Self-Powered Multimodal Sensing

Jiawei Gu,Qiongle Peng,Xuanqi Zhong,Yi Zheng,Zhiqiang Ma,Xiaoxian Song,Ruihuan Zhang,Bao Liu,Yanhu Zhang,Zhengbao Yang

The pursuit of multifunctional sensors has intensified due to their potential for integrated, efficient operation. However, realizing a flexible material that combines simplicity in the fabrication process with high performance and multifunctionality remains a formidable challenge. In this study, a multi-interface heterostructured nanofiber membrane composed of Polyvinylidene fluoride (PVDF), HfO 2 , and nano-copper is fabricated, leveraging the synergistic interplay of piezoelectric and piezo-phototronic effects for flexible, self-powered sensing. The incorporation of hafnium oxide (HfO 2 ) and nano-Cu enhances the crystallinity of the piezoelectric β -phase and improves the dielectric properties, substantially boosting electromechanical performance. The resultant piezoelectric sensor achieves an output voltage of 15V and maintains stability over 5000 cycles at 5 Hz, enabling precise detection of human motions. Meanwhile, the PVDF/HfO 2 -based photodetector exhibits broadband sensitivity (from near-UV to near-IR), high photoresponsivity (5.67 mA W −1 ), high detectivity (4.14×10 11 Jones), and rapid response (600 µs rising, 53 µs falling). Critically, the device demonstrates a 28.6% current enhancement under simultaneous light and pressure, highlighting a strong piezo-phototronic effect. This work presents a multifunctional fiber film for dual-mode sensing (pressure & light), with promising applications in wearable electronics and aerospace systems. Its straightforward fabrication and high performance offer a viable pathway toward next-generation, flexible, self-powered sensors.

Highly stable and re-dispersible nano Cu hydrosols with sensitively size-dependent catalytic and antibacterial activities

Yu Zhang,Pengli Zhu,Gang Li,Wenzhao Wang,Liang Chen,Daoqiang Daniel Lu,Rong Sun,Feng Zhou,Chingping Wong

Highly stable monodispersed nano Cu hydrosols were facilely prepared by an aqueous chemical reduction method through selecting copper hydroxide (Cu(OH)2) as the copper precursor, poly(acrylic acid) (PAA) and ethanol amine (EA) as the complexing agents, and hydrazine hydrate as the reducing agent. The size of the obtained Cu colloidal nanoparticles was controlled from 0.96 to 26.26 nm by adjusting the dosage of the copper precursor. Moreover, the highly stable nano Cu hydrosols could be easily concentrated and re-dispersed in water meanwhile maintaining good dispersibility. A model catalytic reaction of reducing p-nitrophenol with NaBH4 in the presence of nano Cu hydrosols with different sizes was performed to set up the relationship between the apparent kinetic rate constant (kapp) and the particle size of Cu catalysts. The experimental results indicate that the corresponding kapp showed an obvious size-dependency. Calculations revealed that kapp was directly proportional to the surface area of Cu catalyst nanoparticles, and also proportional to the reciprocal of the particle size based on the same mass of Cu catalysts. This relationship might be a universal principle for predicting and assessing the catalytic efficiency of Cu nanoparticles. The activation energy (Ea) of this catalytic reaction when using 0.96 nm Cu hydrosol as a catalyst was calculated to be 9.37 kJ mol−1, which is considered an extremely low potential barrier. In addition, the synthesized nano Cu hydrosols showed size-dependent antibacterial activities against Pseudomonas aeruginosa (P. aeruginosa) and the minimal inhibitory concentration of the optimal sample was lower than 5.82 μg L−1.

Composition Design of Ni-Nano-Cu-BTC@Ag Coatings with Low Friction and Their Intelligent Electrical Control Behavior

Yuyun Wang,Guoliang Zhang,Duo Yang,Yang Li,Wei Yin,Jingshui Xu

At present, Ni-based coatings are rarely used in the field of voltage control friction because of their poor antifriction, wear resistance, and conductive properties. Therefore, in this paper, Cu-BTC@Ag nanocrystals were used to enhance the nickel coatings, and the effect of voltage on their tribological properties was also investigated. It was found that the grains of coating were refined via the addition of Cu-BTC@Ag nanocrystals, leading to an improvement in the hardness and corrosion resistance of this composite coating. The tribological performance of nickel composite coating could be controlled under different electrical fields. With the comparison of the pure Ni-based coating, the average friction coefficient and wear volume of its composite coating with 5 wt % Cu-BTC@Ag were reduced by 7.0 and 91.8%, respectively, which showed excellent wear resistance without an applied voltage. Under the condition of 20 V, the 5 wt % Cu-BTC@Ag/Ni-based composite coating owned outstanding antifriction performance. Therefore, Cu-BTC@Ag played an intelligent role in regulating the friction of Ni-based coatings under an external voltage. It is due to the accumulation of Cu-BTC@Ag nanocrystals on the surface of the coating under the action of voltage, which played the role of supporting load and effectively reducing wear.

Nano-Cu Particles Modified Graphene-Polyvinyl Alcohol Foam Composite Phase Change Materials for Efficient Solar-Thermal Conversion and Storage

Xiaoxiao Huang,Jianguo Duan,Qihui Yu,Qing Ma

Graphene composite phase change materials (PCMs) show great application potential in solar energy conversion and storage due to their strong light absorption and high thermal conductivity. To further enhance the photothermal conversion and leakage prevention performance of graphene composite PCMs. This article adopts a “point-surface” modification strategy. Through a hydrothermal reduction self-assembly method, nanocopper particles are doped into polyvinyl alcohol (PVA) cross-linked graphene nanosheets to construct a novel graphene nanosheet-nanosized Cu particle/polyethylene glycol (PEG) composite PCMs. The random distribution of nanocopper particles significantly enhances the spectrum absorption capacity and interfacial heat transfer efficiency of the graphene skeleton. The results show that the thermal conductivity of PEG/PG–Cu 0.06 reaches 0.793 W/m −1 k −1 , which is 317.4% of pure PEG. Its latent heat enthalpy value reaches 185.7 J g −1 , and the enthalpy value attenuation rate after 200 thermal cycles is less than 0.21%. Moreover, when the simulated light intensity was 120 mW cm −2 , the PEG/PG–Cu 0.06 photothermal conversion efficiency is 86.2%. Meanwhile, the cross-linked network formed by PVA and graphene can effectively inhibit PEG leakage, and the leakage rate of PEG/PG–Cu 0.06 is 21.6%. Additionally, the 3D graphene-PVA matrix modified by nano-Cu particles is used to improve the thermal conductivity and the spectrum adsorption capacity of composite PCMs, which have excellent photothermal conversion performance and thermal stability and have great application prospects in solar energy heat storage.

Carbon dots-anchored and stabilized nano Cu/Cu2O composites for constructing highly sensitive and stable non-enzymatic glucose electrochemical sensor

Shuang Zhou,Yuru Yang,Qingmiao Pu,Bingyu Luo,E. Li,Jiao Fu,Xiaodong Su,Zhenfu Jia

A flexible non-enzymatic glucose electrochemical sensor with high sensitivity and stability was constructed using the electrode by in situ growth of Cu/Cu 2 O nanocomposites on carbon dots (CDs) modified carbon cloth (CC) by electrodeposition reduction method, where the modification of CDs provided a stable anchoring site for the growth of the nanocomposites and enhanced the stability of Cu/Cu 2 O in solution. The electrode had a glucose detection range of 0.2–100 μM and 0.1–1 mM, which offered the advantages of high sensitivity (4510.89 μA mM −1 cm −2 and 2385.94 μA mM −1 cm −2 ) and low detection limit (0.66 μM). The sensor also exhibits excellent selectivity, reproducibility, immunity to interference and long-term stability. In addition, In order to verify the enhancement effect of CDs on their electrochemical properties, Cu/Cu 2 O electrodes were prepared in this paper by the same method on several CCs modified with different CDs (e.g., glycine, cysteine and riboflavin), The results showed that the incorporation of CDs enhanced the electrocatalytic ability compared to the electrode without CDs modification, indicating that CDs can provide more active sites and electron transport channels for Cu/Cu 2 O, and that this CDs-enhanced Cu/Cu 2 O nanocomposite can be used for non-enzymatic glucose electrochemical sensors.

Preparation and properties of carmine radish cellulose/nano-Cu composite porous material and its application for catalytic degradation of organic dyes

Zhu Xiong,Huisheng Huang,Fenggui Chen,Shuying Kong,Fulan Zhang

Transforming agricultural waste into functional catalysts addresses both environmental and resource challenges. Specifically, cellulose from discarded carmine radish residue (CRC) was made into a porous support for copper nanoparticles (Cu NPs). Inherent brittleness limits cellulose-based materials' practical use, so hexamethylene diisocyanate (HDI) was introduced as a covalent crosslinker. This approach replaces partial interchain hydrogen bonds with urethane linkages, building a resilient three-dimensional (3D) network in the CRC matrix. FTIR, XRD and 2D-WAXS verified the crosslinking, while low-field NMR showed the chemical network accounted for roughly 66.77% of the system. Mechanical properties were notably enhanced: compressive modulus rose from 30 kPa to 130 kPa, compressive strength stayed at 80 kPa, and compressive strain increased from approximately 62% to 81%. Molecular dynamics simulations confirmed cohesive energy dropped from 101.83 kJ mol −1 to 56.27 kJ mol −1 , explaining improved energy dissipation. The toughened CRC scaffold was loaded with ∼35 nm Cu NPs to form a CRC/nano-Cu composite. When applied to catalytic dye degradation using NaBH 4 , the composite achieved near-complete degradation of methylene blue (MB) within 25 min. This performance dramatically outperforms the non-catalytic reaction, which only achieved 29% degradation after 240 min. Furthermore, electrostatic interactions driven by the electron-rich Cu surface conferred strong charge-selectivity for cationic dyes, while the composite retained robust reusability over 5 cycles and high activity under severe ionic interference. This work offers a novel strategy for high-value biomass waste utilization and a mechanism for designing strong bio-based catalytic materials by enhancing energy dissipation through covalent crosslinking.