Journal of Materials Chemistry B
·
2014
·Vol. 3
·期 5
·911-918
·
IF 0
Yuhua Song,Tingbin Zhang,Xiaoyan Song,Ling Zhang,Chunqiu Zhang,Jinfeng Xing,Xing-Jie Liang
The low transfection efficiency of polycations is still a major problem for successful gene therapy. To address this issue, in this study, hydrophilic poly(vinyl pyrrolidone)-graft-poly[2-(N,N-dimethylamino)ethyl methacrylate] (PVP-g-PDMAEMA) and amphiphilic poly(vinyl pyrrolidone)-graft-poly[2-(N,N-dimethylamino)ethyl methacrylate]-block-poly(methylmethacrylate) (PVP-g-PDMAEMA-b-PMMA) were synthesized via the atom transfer radical polymerization (ATRP) method, and their properties as gene vectors were investigated subsequently. PVP-g-PDMAEMA formed random coils in water and PVP-g-PDMAEMA-b-PMMA self-assembled into spherical core–shell micelles with a very low critical micelle concentration of only 6.3 × 10−3 mg mL−1. PVP-g-PDMAEMA-b-PMMA/pDNA polyplexes demonstrated an excellent gene transfection efficiency, which showed not only much higher gene transfection efficiency than PVP-g-PDMAEMA/pDNA polyplexes, but obviously surpassed 25k PEI at low N/P ratio around 3 on 293T cell lines. Hence, the results suggested that PVP-g-PDMAEMA-b-PMMA could be a highly efficient gene vector.
研究领域:
生物化学
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基因治疗
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
Journal of Inorganic and Organometallic Polymers and Materials
·
2018
·Vol. 29
·期 1
·59-65
·
IF 1.754
Yang Zhenglong,Fu Kangyu,Yu Jing,Liu Xinyan
The organic/inorganic hybrid material of poly[2-(dimethyl amino)-ethyl methacrylate]/polyhedral oligomeric silsesquioxane (POSS–PDMAEMA) was synthesized via a thiol-Michael addition reaction. The structures of POSS–PDMAEMA and its self-assembly in aqueous solution were confirmed by 1 H-NMR, TEM, DLS, UV–Vis and fluorescence spectrum. In aqueous solutions, POSS–PDMAEMA could self-assemble into micelles and its critical micelle concentration was 12.4 mg/L. POSS–PDMAEMA micelles can adsorb dyes efficiently, it could adsorb methyl red at a concentration of 10–100 mg/L and dithizone at a concentration of 20–100 mg/L, and could remove 98% methyl red and 90% dithizone within 30 s. Due to the good temperature and pH responsiveness, POSS–PDMAEMA micelles could release organic dye absorbed into the organic solution again when the solution was heated to 40 °C or pH value of the solution was adjusted to 4.0. It suggested that POSS–PDMAEMA can be utilized as an interesting “smart” materials for absorption of organic dyes.
研究领域:
材料科学
·
环境科学
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产品关联
DOI
高影响因子
SOFT MATERIALS
·
2015
·
IF 1.244
Yi Chen,Guangsheng Zeng,Wenyong Liu,Weijian Xu
A novel POSS hybrid nanocomposite hydrogel was designed and synthesized by introducing water-soluble Oa-POSS into the PDMAEMA hydrogels physically cross-linked by clay. The prepared OaP-NC gels exhibited obvious temperature and pH double responsiveness while the properties and structure of gels depended on the content of added Oa-POSS. The swelling ratio of OaP-NC gels decreased slightly and the deswelling rate raised gradually with the increase of Oa-POSS. Moreover, the tensile strength and resilience of OaP-NC gels was improved significantly. Interestingly, the swelling behavior of gels changed differentially in the drying/reswelling circulation process due to the rearrangement of particles in gels.
研究领域:
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF POLYMER SCIENCE
·
2024
·
IF 3.9
Xin Luo,Zhuqing Wang,Mengxia Yan,Jianhui Xin,Yongqi Yang,Longpo Zheng,Haijun Zhang
CO 2 -responsive based separation membranes are attractive in the field of membrane separation, not only for their ability to modulate the pore size of the membrane in response to CO 2 stimulation, but also for their ability to facilitate the removal of contaminants from the membrane surface. However, the introduction of CO 2 -responsive polymers by simple blending often results in membranes that are not responsive enough to last. In this study, we synthesized a hooked triblock copolymer and used it as an additive to prepare CO 2 -responsive PVDF membranes. The modified membrane combines the advantages of the PVDF material with the CO 2 response of the triblock copolymer. It not only has good CO 2 responsiveness, but also removes organic contaminants from the membrane surface well. The water flux of the hybrid membranes is 4 to 11 times higher than that of pure PVDF membranes, indicating that the triblock copolymer also has some porogenic ability. Surprisingly, the static contact angle on the membrane surface increased from 67° to 86° with the increase of the triblock copolymer content in the PVDF membrane. This suggests that modified PVDF membranes have some potential in the field of switchable oil–water separation. Graphical
研究领域:
膜科学
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材料科学
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环境工程
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产品关联
DOI
高影响因子
COLLOID AND POLYMER SCIENCE
·
2020
·Vol. 299
·期 4
·663-674
·
IF 1.536
Xia Yunfei,Xu Xiuhang,Yu Haihua,Zhou Chuan,Nie Zhenzhou,Yang Jianfeng,Qian Jiajia,Ni Henmei
Zwitterionic microspheres of poly2-(dimethylamino) ethyl methacrylate (PDMAEMA) block polymethacrylic acid (MAA) were prepared by RAFT dispersion polymerization in alcohols. 4-Cyano-4-(phenylcarbonothioylthio) pentanoic acid (CPDB) was used as the RAFT agent. 2,2′-Azobis(2,4-dimethyl) valeronitrile (V65) was used as the initiator, and PDMAEMA-CPDB was used as the macro-chain transfer agent (CTA). 1 HNMR was applied to determine the polymerization degrees of both PDMAEMA-CTA and PDMAEMA-b-PMAA. SEM, dynamic light scattering (DLS), and small-angle X-ray diffraction (SAX) were employed to characterize the microspheres. It was observed that the polarity of alcohols impacted the partition of MAA and V65 between the mini-droplets of PDMAEMA-CTA/MAA complexes and the continuous phase, thereby affected on the diameters of microspheres, the total conversion of MAA, and the polymerization degree of PMAA in the copolymers. For example, in methanol, the smallest diameter and polymerization degree of PMAA in the block copolymers were obtained, whereas the total conversion of MAA of the RAFT polymerization system was the highest. Most of RAFT polymerization of MAA occurred nearby PDMAEMA-CTA chains; thus, PDMAEMA-CTA acted as a template to regulate the length of PMAA in the copolymers. pH-sensitive characteristics of microspheres were dependent to the extra length of PDMAEMA-CTA, i.e., the difference of lengths between two blocks. When the length of PMAA was too short, e.g., PDMAEMA 600 -b-PMAA 87 , or the length of PMAA was closed to that of PDMAEMA, e.g., PDMAEMA 79 -b-PMAA 93 and PDMAEMA 102 -b-PMAA 131 , the amphoteric characteristics of microspheres disappeared. The self-assembly behavior of diblock copolymers in KCl alcohol-water solution was also determined by the extra length of PDMAEMA. Microspheres turned into nanofibers or nano-ribbons, but for PDMAEMA 600 -b-PMAA 87 , the microspheres maintained their original spheric morphology. These results indicated that the charge-screening effects of salts played the key roles in the self-assembly.
Graphical abstract
研究领域:
高分子化学
·
材料科学
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产品关联
DOI
高影响因子
CHINESE JOURNAL OF CHEMISTRY
·
2017
·Vol. 35
·期 7
·1109-1116
·
IF 1.852
Naixu Li,Jun Yin,Lingfei Wei,Quanhao Shen,Wei Tian,Jing Li,Yong Chen,Jing Jin,Hongcheng Teng,Jiancheng Zhou
We fabricate a novel cellulose acetate (CA) ultrafiltration membrane modified by block copolymer F127-b- PDMAEMA, which is synthesized using F127 and DMAEMA via the ARGET ATRP method. Compared to conventional ultrafiltration membranes, the incorporation of both F127 and PDMAEMA can not only readily increase the hydrophilicity of the membrane, but also exhibit stimuli-responsiveness to temperature and pH. Fourier transform infrared spectroscopy (FT-IR), nuclear magnetic resonance spectroscopy (NMR), and gel permeation chromatography (GPC) are employed to analyze the structure of the F127-b-PDMAEMA. The membrane properties are evaluated via scanning electron microscope (SEM) imaging, porosity test, automatic target recognition Fourier transform infrared spectroscopy (ATR-FTIR), water contact angle test and permeation test. The results indicate that the F127-b-PDMAEMA is an excellent pore agent, which contributes to an enhancement of the membrane in sensitivity to temperature and pH. The modified membrane also exhibits lower water contact angle (64.5°), which is attributed to the good anti-fouling performance and high water permeation.
研究领域:
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
RSC Advances
·
2016
·Vol. 6
·期 95
·92305-92315
·
IF 3.289
Yeqiang Tan,Wenqian Zhang,Yanhui Li,Yanzhi Xia,Kunyan Sui
Well-defined modification of multi-wall carbon nanotubes (MWNTs) with different molecular weight poly(2-(dimethylamino)ethyl methacrylate) (PDMAEMA) was high-efficiently realized by atom transfer nitroxide radical coupling (ATNRC), which was confirmed by 1H NMR, TEM and thermogravimetric analyses (TGA). The multi-responsive behaviors of PDMAEMA modified MWNTs (MWNTs-g-PDMAEMA) suspensions were systematically investigated by rheology. Reversible thermo-thickening behavior was detected in MWNTs-g-PDMAEMA suspensions, attributing that PDMAEMA side chains aggregated to hydrophobic micro-domains physically cross-linking the polymer chains at temperatures above LCST. By the incorporation of sufficient free PDMAEMA chains (f-PDMAEMA), the suspensions with enough long grafted-chains exhibited obvious shear-thickening behaviors at high pH, which was absent in the suspensions with short grafted-chains due to steric hindrance of MWNTs as backbones. The primary mechanism of shear thickening was ascribed to the shear-induced transformation of intra-chain cross-linking to inter-chain cross-linking induced by the bridging effect of additional free-chains. Hydrophobic interaction, the amount of f-PDMAEMA chains and grafted-chain length were determined as the three vital factors of shear-thickening behaviours, which could be employed to fulfill tunable thickening/thinning responsive of MWNTs-g-PDMAEMA. In the study of self-assembly properties of MWNTs-g-PDMAEMA and the hybrid system of Au nanoparticles immobilized MWNTs-g-PDMAEMA dilute aqueous suspensions, typically dendritic fractal patterns with different details were formed in response to pH values and the concentration of NaCl, which have not been reported in the literature yet. The morphology of the self-assembled hybrid systems of Au nanoparticle immobilized MWNTs-g-PDMAEMA aggregates gradually transformed from rigid, straight and wide trunks with few side branches to soft, bent and slim trunks with many side branches as the pH value increased. The insights reported here can help to deeply understand the thickening/thinning essence and self-assembly principle of polymer brush grafted MWNTs suspensions, and guide the development of complex responsive materials with better performance.
研究领域:
材料科学
·
高分子化学
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
Soft Matter
·
2021
·Vol. 17
·期 41
·9363-9370
·
IF 3.679
Haifeng Liu,Yifeng Sun,Zhonghui Chen
Hydrophobic/oleophilic sponges are excellent absorbent materials for oil contaminant removal. However, the application is limited in dealing with surfactant stabilized O/W emulsions. The water in the emulsion isolates the contact between the sponge and oil droplets. Consequently, the oil absorption efficiency is not ideal. Herein, to improve the oil absorption efficiency from anionic surfactant stabilized O/W emulsions, water responsive hybrid sponges were reported. To prepare such sponges, water soluble poly(N,N-dimethylaminoethylmethacrylate) (PDMAEMA) was introduced into polydimethylsiloxane (PDMS) sponges using table salt as a template and multi-walled carbon nanotubes (MWCNTs) as mechanical reinforcement in a one-pot method. Upon contact with an O/W emulsion, the water soluble PDMAEMA chain rose to the surface of the sponge, turning the hydrophobic surface into hydrophilic. Next, the tertiary amine groups in PDMAEMA ionized in water and carried positive charges which would cause the coagulation of oil droplets. Finally, the coagulated oil droplets were absorbed immediately by the oleophilic inner part of the sponge through the wicking effect. As a result, a Janus interface was generated in situ and sustained. Such material design synergistically contributed to a satisfactory hexadecane (HD) absorption efficiency of 178 ± 4% in 25 min. In contrast, the PDMS-MWCNT1.0% sponge could only absorb 9.8 ± 0.2% HD. Moreover, these sponges also presented robust mechanical performance and reusability, offering a new route for oil/water separation and oil pollution remediation in open water.
研究领域:
材料科学
·
环境工程
·
化学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2016
·Vol. 6
·期 32
·27102-27112
·
IF 3.289
Lei Li,Beibei Lu,Qikui Fan,Lulu Wei,Jianning Wu,Jun Hou,Xuhong Guo,Zhiyong Liu
In this work, well-defined pH-responsive methoxy poly(ethylene glycol)-block-poly(ε-caprolactone)-block-poly[2-(dimethylamino)ethyl methacrylate]-g-7-propinyloxy coumarin triblock amphiphilic copolymers (mPEG-b-PCL-b-PDMAEMA-g-PC) were synthesized using a combination of atom transfer radical polymerization (ATRP), ring opening polymerization (ROP) and click chemistry. The chemical structures and compositions of these copolymers were characterized using Fourier transform infrared spectroscopy (FT-IR) and proton nuclear magnetic resonance (1H NMR). The molecular weights of the copolymers were obtained using 1H NMR spectroscopy and gel permeation chromatography (GPC) measurements. Subsequently, the polymers could self-assemble into micelles which were investigated using dynamic light scattering (DLS), transmission electron microscopy (TEM), and fluorescence spectroscopy. The pH-responsive self-assembly behavior of these triblock copolymers in water were investigated at different pH values of 5 and 7.4 for controlled doxorubicin release, the results indicated that the release rate of DOX could be effectively controlled by altering the pH, DOX was sealed in neutral surroundings and DOX release was triggered in acidic surroundings. CCK-8 assays and confocal laser scanning microscopy (CLSM) against HeLa cells indicated that the micelles had no associated cytotoxicity, possessed good biodegradability and biocompatibility, and identified the location of the DOX in HeLa cells. The DOX-loaded micelles possessed high cytotoxicity to HeLa cells and exhibited inhibition of the proliferation of HeLa cells. Moreover, these flexible micelles with an on–off switched drug release may offer a promising pattern to deliver a wide variety of hydrophobic payloads to tumor cells for cancer therapy.
研究领域:
材料科学
·
纳米技术
·
药学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2013
·Vol. 48
·期 17
·5750-5755
·
IF 2.163
Song Kai,Zhao Xiaoying,Xu Yueming,Liu Hewen
In this paper, we report on an effective surface modification method for the functionalization of graphene oxide (GO) via photo-initiated radical polymerization. Two cases are investigated, i.e., photoinitiators are chemically attached on GO or are just mixed with GO. The monomer used for surface graft is water-soluble 2-(dimethylamino) ethyl methacrylate (DMAEMA). Analysis based on Fourier transform infrared spectra, Raman spectra, X-ray photoelectron spectroscopy, thermogravimetric analysis, and element analysis demonstrates that PDMAEMA chains are successfully grafted onto GO surface in both cases. In addition, we study the effects of UV irradiation energy and the concentration of initiators on the polymerization. Both UV irradiation energy and the concentration of initiators do not have significant effects on the grafting degree; however, the concentrations of the initiators have impact on the length of the polymer chains grafted onto GO in the case of mixed photoinitiators with GO. The chain length of polymer is shorter with the higher photoinitiator concentration.
研究领域:
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
EUROPEAN POLYMER JOURNAL
·
2013
·
IF 2.562
Xiaohong Wang,Guohua Jiang,Zhen Wei,Xia Li,Bolin Tang
The CO 2 stimulus-sensitive nanoparticles based on poly( N , N -dimethylaminoethyl methacrylate)- b -poly styrene (PDMAEMA- b -PS) were prepared via surfactant-free miniemulsion reversible addition–fragmentation chain transfer (RAFT) polymerization. The as-prepared nanoparticles exhibited core–shell structure with about 120 nm in diameter. Their dispersion/aggregation in water can be adjusted by alternatively bubbling of CO 2 and N 2 . Drug release from these nanoparticles can be accelerated (or delayed) by bubbling (or removing) of CO 2 .
研究领域:
材料科学
·
药学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2017
·Vol. 134
·期 38
·45326
·
IF 1.86
Yi Chen,Wenyong Liu,Guangsheng Zeng,YueJun Liu
The microporous hydrogels (P n -C m gels) composed of poly(dimethylaminoethyl methacrylate) and carboxymethylchitosan were synthesized in situ radical polymerization by using nano γ-Fe 2 O 3 particles as pore-agent. The microporous structure formed through eliminating the Fe 2 O 3 particles was designed to achieve a faster response rate and better drug loading effect. Comparing to the neat gels, P n -C m gels exhibit deteriorative mechanical properties with the increased pores, while the gels still keep the elastic network structure which could bear some degree of tensile and compression deformation. Meantime, P n -C m gels show similar temperature and pH double responsiveness with same isoelectric point shrink as that of neat gels, the swelling ability decreases slightly, and the deswelling rate increases with the increase of pores. Moreover, the 5-fluorouracil was used as a target drug to explore the potential of this gel applied as drug-release system. For P n -C m gels, the more pores and carboxymethyl chitosan inside the gels are beneficial to the drug loading, all gels show a burst release of drug, being followed by a slow and sustained release with different rate. Comprehensively, the P n -C m gels exhibit a better sustained release effect in the simulated stomach condition (pH = 2.1), the related release mechanism could be interpreted by the superposition of Fickian diffusion. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017 , 134 , 45326.
研究领域:
材料科学
·
生物医学工程
·
药剂学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）