RSC Advances
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2020
·Vol. 10
·期 41
·24507-24514
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IF 3.119
Peihong Li,Xueyan Dai,Lijie Qu,Yanlong Sui,Chunling Zhang
Peptide-containing hydrogels have become a research hotspot due to their unique secondary structure and biocompatibility. Herein, we used amino-terminated F127 as a macroinitiator to initiate the ring-opening polymerization of L-lysine(z)-NCA, and the obtained oligo(lysine)-modified F127 (FL) had degrees of polymerization of lysine of 2, 5, and 8. The results showed that the FL hydrogels had reversible temperature-dependent sol–gel transitions, and the introduction of lysine increased the critical gel temperature. In the dilute solution of FL, the micelle size increased and aggregated as the pH increased; the micelle grew into a rod-like shape under alkaline conditions. Scanning electron micrographs showed that the interior of the FL hydrogel had a more complete porous structure. The FL-2 hydrogel loaded with 5-fluorouracil exhibited an approximately linear release trend within 12 h and has good biocompatibility. Therefore, FL hydrogels have potential applications in the field of biomedicine.
研究领域:
生物材料
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药剂学
·
高分子化学
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DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2024
·
IF 8.1
Leiyu Huang,Jingyang Zhao,Yunjian Chen,Bei Zhang,Jiandu Lei,Luying Wang
Suitable imprinting methods and carriers for preparing molecularly imprinted materials can improve both the adsorption capacity and selectivity of proteins. In this study, surface molecularly imprinted materials on wood-based carriers (MIPs@KW-Si) were successfully constructed, with temperature/pH dual-responsive ability and dynamic adsorption for selective recognition of ovalbumin (OVA) template molecules. Balsa wood was delignified, modified by silane and was used as a porous carrier to obtain MIPs@KW-Si. The MIPs@KW-Si can well recognize OVA at a pH of 8.5 and a temperature of 25 °C, showing an OVA adsorption capacity of 23.96 mg·g −1 and a high recognition capacity (imprinting factor of 4.26) at a short adsorption equilibrium time of 60 min. The OVA adsorption process of MIPs@KW-Si followed the Pseudo-second-order model and Langmuir model, meaning a monolayer chemisorption with a maximum saturated adsorption of 35.91 mg·g −1 . MIPs@KW-Si also had strong specific adsorption capacity for OVA, and the selection factors (α) for bovine serum albumin (BSA) and bovine hemoglobin (BHB) could reach 6.47 and 45.5, and the adsorption capacity remained above 86 % of the equilibrium adsorption capacity after five repeated regeneration experiments. Additionally, a filter constructed by MIPs@KW-Si can achieve a filtration process for fast adsorbing OVA, with an excellent adsorption/desorption effect. The study shows that MIPs@KW-Si is an ideal molecularly imprinted material for OVA with broad potential applications.
研究领域:
生物材料学
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蛋白质科学
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产品关联
DOI
高影响因子
JOURNAL OF CHROMATOGRAPHY A
·
2024
·
IF 3.8
Chengcheng Yang,Wen Deng,Fei Li,Mengting Gong,Hui Li,Xiaorong Mi,Sitong Ma
A pH/temperature bi-responsive gallic acid magnetic imprinted polymer (PTBG-MIP) was synthesized on a Fe 3 O 4 @SiO 2 @KH570 carrier using methacrylic acid (MAA), p-Vinylphenylboronic acid (p-VPBA), and N-isopropyl-acrylamide (NIPAAm) as complex functional monomers. The density functional theory (DFT) was employed to optimize the molar ratio of multi-functional monomers-template complex, which proved to be an effective tool for predicting complex configuration based on electrostatic potential (ESP) analysis and the lowest binding energy. DFT calculation and analysis determined the optimized molar ratio of 2:1:1:1 for GA-MAA-NIPAAm-p-VPBA, which showed good agreement with experimental results. The PTBG-MIP-4 obtained under the optimized conditions exhibited high pH- and temperature- dependence in rebinding the template, displaying a maximum adsorption capacity ( Q e ) of 62.26 mg g −1 and a highest selection factor (α) of 5.217. Additionally, the PTBG-MIP-4 exhibited exceptional physicochemical properties encompassing magnetization characteristics, morphology, surface sites distribution, and adsorption performance. The application efficiency of this imprinted composite in the extraction and purification of gallic acid from Galla chinensis was remarkably demonstrated.
研究领域:
材料科学
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天然产物化学
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产品关联
DOI
PubMed
高影响因子
APL Bioengineering
·
2023
·Vol. 7
·期 1
·
IF 6
Wang Jun,Wu YanYan,Liu Kai,Yang Weitao,Zeng Weiwei,Gao Xiaolong,Liu ShiYuan,Zhang Bingbo
The development of a combination of chemo/photothermal therapy could overcome the limitations of single-modality therapy and enhance therapeutic efficacy. In this study, a pH/thermal dual-responsive multifunctional drug delivery system with dual-drug loading and enhanced chemo/photothermal therapy is developed based on polydopamine-coated mesoporous silica-gold nanorods (PDA-AuNRs@MSN). Nanoscale mesoporous silica-gold nanorods encapsulating doxorubicin (DOX) are designed as a core and then modified by polydopamine. The PDA shell not only conjugates with another anticancer bortezomib (Btz) to form pH-sensitive bond through boronic acid and catechol but also acts as a gatekeeper to control the release of doxorubicin and enhance the photothermal effect. Such a nanocarrier not only acts as a contrast agent for PA imaging but also serves as a therapeutic agent for enhanced chemo/photothermal therapy. The DOX and Btz could be released in an on-demand mode under near-infrared light irradiation and acid environment. The tumor size and location could be observed via PA imaging after intravenous injection into 4T1-bearing mice. Compared with AuNRs@MSN, PDA-AuNRs@MSN exhibit an increased near-infrared (NIR) absorption at 808 nm and an enhanced photothermal effect. The integrated D/B-PDA-AuNRs@MSN nanoparticles show higher cell apoptosis and enhanced tumor treatment efficacy in vitro and in vivo in comparison with single chemotherapy or photothermal therapy. Combined together, D/B-PDA-AuNRs@MSN show pH/thermal-responsive controlled-release and synergistic chemo/photothermal therapy for tumor.
研究领域:
生物医学工程
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肿瘤治疗
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纳米药物递送
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产品关联
DOI
PubMed
高影响因子
Materials Today Bio
·
2025
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IF 10.2
Zhiwei Jiang,Song Wang,Qian Xiang,Ying Wang,Songchao Fu,Huibiao Deng,Qing He,Yue Wang,Zheng Mao,Cihui Liu,Hui Deng,Xinjian Wan
Precise drug delivery in the biliary tract remains challenging due to the dynamic physiological environment and lack of control in existing systems. Here we report a thermo- and pH-responsive semi-permeable catheter with unidirectional drug transport and integrated with machine learning-based environmental state recognition. Addressing the critical challenges of low local drug delivery efficiency and the difficulty of systems adapting to dynamic physiological environments in biliary tract diseases, the catheter adapts its swelling behavior and drug permeability in response to changes in temperature and pH. To achieve precise state recognition, real-time electrical signal data is classified using supervised and unsupervised learning algorithms. We simulated six distinct biliary states and achieved over 95% accuracy in state recognition using a Random Forest model with Gini-based feature selection. The directional wall design ensured asymmetric diffusion and localized drug release. The research findings demonstrate a system capable of sensing and learning from environmental stimuli, laying the foundation for adaptive biliary tract treatment.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CRYSTAL RESEARCH AND TECHNOLOGY
·
2020
·Vol. 55
·期 10
·2000039
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IF 1.169
Zeqiu Xia,Lin Wang,Gaohong He,Xiaobin Jiang
Crystal morphology control is a common concern for the crystal engineering and relevant applications. For example, urate crystallization is important for the study of the hyperuricemia induced gout. Herein, biomimetic hydrogel material with uniform surface and vertical structure is fabricated, which possesses hybrid pH-temperature responsibility for high-efficiency interfacial nucleation and concentration regulation functions. The developed hydrogel layers are prepared to slice type as a functional microplatform and then added into the uric acid dihydrate (UAD) crystal solution to induce monosodium urate monohydrate (MSUM) crystallization. With different dosage of the hydrogel slices (HGS) in the solution, diverse crystal morphologies can be obtained in an efficient manner, such as “flower,” “sphere,” “sticky spheres,” which entirely distinguishes from the one prepared via no-HGS. This work explores a new path for revealing the relevant crystallization mechanism and developing crystal morphology control technology with hydrogel interfacial materials.
研究领域:
材料科学
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晶体工程
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生物医学工程
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化学
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产品关联
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2019
·
IF 3.131
Hui Zhao,Ying Li
Tremella polysaccharide , a novel polysaccharide , not only has good ability of film forming, but also has excellent physiological functions, which was suitable to be used to prepare eco-friendly hydrogels. In this study, a novel pH/temperature responsive micelle-laden hydrogel based on tremella polysaccharide (WSK), carboxymethyl cellulose (CMC) and nonionic surfactant-decyl polyglucoside (C 10 APG) was fabricated through radical polymerization by crosslinking N-isopropylacrylamide (NIPAM), for the purpose to achieve controlled release of hydrophobic drugs indomethacin (IND). Firstly, WSK/CMC/PNIPAM hydrogels were prepared and their characteristics were investigated by FTIR, TGA , SEM, rheological and compressive tests as well as swelling experiments. Then the hydrophobic drug IND molecules were solubilized in C 10 APG micelles which were uniformly dispersed in the WSK/CMC/PNIPAM/C 10 APG networks. Lastly, the IND release behavior of WSK/CMC/PNIPAM/C 10 APG hydrogels was studied, which exhibited both pH and temperature sensitivity. The obtained WSK/C 10 APG-based pH/temperature sensitive hydrogel may have potential in biomedical applications such as drug vehicles and tissue engineering.
研究领域:
材料科学
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药学
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生物医学工程
·
高分子化学
✓ 已验证
DOI
高影响因子
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2024
·
IF 3.8
Ali Nasir,Yutong Liu,Wang Fuyi,Qi Li
Recently, open tubular capillary electrochromatography (OT-CEC) has captured considerable interest; its efficient separation capability hinges on the interactions between analytes and polymer coatings. However, in situ growth of stimuli-responsive polymers as coatings has been rarely studied and is crucial for expanding the OT-CEC technique and its application. Herein, following poly(styrene-maleicanhydride) (PSM) chemically bonded onto the inner surface of the capillary, a dual pH/temperature stimuli-responsive block copolymer, P(SMN-COOH), was prepared by in situ polymerizing poly( N -isopropylacrylamide) carboxylic acid terminated [P(N-COOH)] in PSM. An OT-CEC protocol was first explored using the coated capillary for epimedins separation. As a proof of concept, the developed OT-CEC system facilitated hydrogen bonding and tuning the hydrophilic/hydrophobic interactions between the test analytes and the P(SMN-COOH) coating by varying buffer pH and environmental temperature. Four epimedins with similar chemical structures were baseline separated under 40 °C at pH 10.0, exhibiting dramatical improvement in separation efficiency in comparison to its performance under 25 °C at pH 4.0. In addition, the coated capillary showed good repeatability and reusability with relative standard deviations for migration time and peak area between 0.7 and 1.7% and between 2.9 and 4.6%, respectively, and no significant changes after six runs. This work introduces a paradigm for efficient OT-CEC separation of herbal medicines through adjusting the interactions between analytes and smart polymer coatings, addressing polymer coating design and OT-CEC challenges. Graphical Abstract
研究领域:
分析化学
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高分子科学
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药物分析
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产品关联
DOI
PubMed
高影响因子
POLYMER BULLETIN
·
2023
·
IF 3.2
Hua Bingyan,Wei Hongliang,Hu Chunwang,Zhang Yaqi,Yang Shuai,Wang Gang,Guo Tao,Li Jingjing
Herein, a semi-interpenetrating network (semi-IPN) hydrogel (SH/PNA) was prepared by simple free radical polymerization using N-isopropylacrylamide and 2-acrylamide-2-methylpropanesulfonic acid as monomers, poly(ethylene glycol) dimethacrylate as a crosslinking agent, and sodium alginate and humic acid as filled biomolecules. Fourier transform infrared spectroscopy, scanning electron microscopy, X-ray diffraction, and rheometer were used to characterize the structure and properties of the samples. The effect of feeding ratios on the gel mass fraction and swelling properties of the SH/PNA hydrogel was explored to optimize its preparation conditions. The swelling behavior under different pH and temperatures was investigated. The experimental result showed that the SH/PNA hydrogel had excellent water absorption capacity and pH/temperature dual responsiveness. Moreover, SH/PNA hydrogel was used as a carrier of urea to prepare slow-release and water-retention fertilizer by in situ loading method, and slow-release properties of urea in water and soil were measured. Taking into account its good ability for controlled release and water retention, the WSRF was expected to be a promising low-cost, environmentally friendly fertilizer that can be used in agriculture and horticulture.
研究领域:
材料科学
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环境科学
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农业科学
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）