Materials Science & Engineering C-Materials for Biological Applications
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2017
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IF 4.164
Li Qiu,Weirui Zhang,Shuyun Wang,Xu Zhang,Yanbao Zhao,Liuqin Cao,Lei Sun
pH/enzyme-responsive nanocarriers based on porous silica (pSiO 2 ) nanospheres (NSs) were developed for controlled release of drug. The pSiO 2 NSs present uniform spheres and have an average diameter of 100 nm. The pSiO 2 NSs with high specific surface area (835 m 2 ·g − 1 ) and the pore volume (1.24 cm 3 ·g − 1 ) are suitable for drug loading and the loading capacity reaches to 29% for amoxicillin (AMX) model drug. In this system, protocatechuic acid (PCA) and L-glutamic acid (Glu) as linkers were grafting onto the surface of pSiO 2 NSs to conjugate the capping lids. Acid-decomposable ZnO quantum dots (QDs) were introduced to block the partial pores of pSiO 2 via amido bonds, which could act as gates and fluorescence probes. To minimize the premature release, hyaluronic acid (HA) was further coating on the outer surface of pSiO 2 , which would be degraded by over-expressed hyaluronidase (Hyal-1) in the tumor microenvironment. The controlled release of the drug from the ZnO/HA-gated delivery system was realized by the acidic dissolution of ZnO QDs and enzymatic hydrolysis of HA. The obtained ZnO/HA-gated pSiO 2 delivery system would achieve minimized premature release and responsive release under a physiological environment.
研究领域:
材料科学
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生物医学工程
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药剂学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INORGANIC CHEMISTRY COMMUNICATIONS
·
2025
·
IF 5.4
Yan Wang,Jiaqi Lu,Menghui Wan,Yanbao Zhao
Asymmetric structures have many potential advantages when used as drug carriers, but the complex synthesis process is an important factor that limits the application of asymmetric structures. In order to simplify the complex preparation method of asymmetric structures, one-pot method was used to prepare a phenolic resin-silica composite materials with a similar snowman morphology. After calcination in air to remove the resin, asymmetric acorn shell-like mesoporous silica (AMS) carriers with rough surface were obtained, which were expected to improve the efficiency of cellular uptake. Subsequently, selective etching was used to expand its specific surface area to obtain EAMS. After loading chemotherapy drug DOX, hyaluronic acid (HA) molecules were applied to block the loaded drug (DOX@EAMS-HA). The DOX@EAMS-HA system performs pH/enzyme-responsive drug release and good therapeutic effect.
研究领域:
材料科学
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纳米技术
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药剂学
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生物医学工程
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药物递送
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Zeyu Wang,Mingxia Liu,Zehua Cheng,Zehao Li,Kexin Zhang,Jing Li,Yifan Zhang,Zihao Fan,Lianrui Cao,Lijiang Chen,Cong Li
Developing multifunctional pesticide delivery systems represents a crucial strategy to address challenges in conventional pesticide applications, including low active ingredient utilization, resistance development, and environmental risk accumulation. This study developed a pH/enzyme dual-responsive nano-delivery system based on carboxymethyl chitosan (LCT@CMCS-g-PCL) for smart targeted delivery and controlled release of lambda-cyhalothrin (LCT). The system's environmental stability, foliar affinity, and stimuli-responsive release behavior were systematically characterized. LCT@CMCS-g-PCL nanoparticles exhibited an average size of 312.5 nm with 23.69 % drug loading and excellent storage stability. Notably, the system showed over 2-fold enhanced resistance to enzymatic degradation and extended photodegradation half-life of LCT from 37.5 h to 187.9 h. Compared with commercial microemulsion (LCT ME), the system showed 17.06 % improvement in foliar deposition efficiency. In vitro release studies confirmed environmental responsiveness, with stable deposition under acidic conditions, triggered release in the alkaline microenvironment, coupled with enzyme activity modulation to delay resistance. Bioassays demonstrated superior pest control efficacy against Plutella xylostella larvae compared to conventional formulations, with the LC 50 value reduced by 39.7 %. Biosafety evaluations confirmed the relative safety for human cells and adult zebrafish, with minimal disturbance to aquatic microbial communities. This study provides an effective strategy for precision pest control, resistance management and environmental risk management in agriculture.
研究领域:
农业科学
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纳米技术
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农药科学
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环境毒理学
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生物安全性
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF CONTROLLED RELEASE
·
2025
·
IF 11.5
Danlei Hu,Dongmei Chen,Aoxue Zhang,Kuiyu Meng,Min Chen,Raja Mubbashar,Wei Qu,Shuyu Xie
Current IBD therapies face limitations such as systemic toxicity, off-target effects, and microbiota dysbiosis. We developed an oral multifunctional gel bead integrating three innovations: (1) a butyrate–apigenin synergy that inhibits NF-κB via CK2/p65 phosphorylation suppression, activates a PPAR-γ-mediated metabolic shift to β-oxidation, and modulates the microbiota by enhancing Bacteroidetes/suppressing Enterobacteriaceae; (2) an apigenin–butyrate ester prodrug overcoming organoleptic issues while enabling CK2 targeting; and (3) a pH/enzyme–responsive delivery system using the FDA-approved ascorbyl palmitate/alginate, achieving gastric protection, charge–mediated colitis targeting, and esterase–triggered release. In colitis model mice, gel beads restore clinical parameters, intestinal integrity, and microbial balance, outperforming apigenin-butyrate ester and 5-ASA at half-doses with extended intervals. It significantly downregulated colon CK2 expression (4.07-fold) and the phospho-P65/total P65 ratio (3.04-fold). This integrated strategy combining multimodal drug actions and precision delivery establishes a new paradigm for efficient and alternative IBD therapeutics with reduced dosing requirements.
研究领域:
药学
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胃肠病学
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药物递送
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分子医学
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微生物组研究
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）