Materials
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2017
·Vol. 10
·期 3
·304
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IF 2.654
Wei-Qing Kong,Cun-Dian Gao,Shu-Feng Hu,Jun-Li Ren,Li-Hong Zhao,Run-Cang Sun
Among the natural macromolecules potentially used as the scaffold material in hydrogels, xylan has aroused great interest in many fields because of its biocompatibility, low toxicity, and biodegradability. In this work, new pH and thermoresponsive hydrogels were prepared by the cross-linking polymerization of maleic anhydride-modified xylan (MAHX) withN-isopropylacrylamide (NIPAm) and acrylic acid (AA) under UV irradiation to form MAHX-g-P(NIPAm-co-AA) hydrogels. The pore volume, the mechanical properties, and the release rate for drugs of hydrogels could be controlled by the degree of substitution of MAHX. These hydrogels were characterized by swelling ability, lower critical solution temperature (LCST), Fourier-transform infrared (FTIR), and SEM. Furthermore, the cumulative release rate was investigated for acetylsalicylic acid and theophylline, as well as the cytocompatibility MAHX-based hydrogels. Results showed that MAHX-based hydrogels exhibited excellent swelling–deswelling properties, uniform porous structure, and the temperature/pH dual sensitivity. In vitro, the cumulative release rate of acetylsalicylic acid for MAHX-based hydrogels was higher than that for theophylline, and in the gastrointestinal sustained drug release study, the acetylsalicylic acid release rate was extremely slow during the initial 3 h in the gastric fluid (24.26%), and then the cumulative release rate reached to 90.5% after sustained release for 5 h in simulated intestinal fluid. The cytotoxicity experiment demonstrated that MAHX-based hydrogels could promote cell proliferation and had satisfactory biocompatibility with NIH3T3 cells. These results indicated that MAHX-based hydrogels, as new drug carriers, had favorable behavior for intestinal-targeted drug delivery.Keywords:Keywords:modified xylan;hydrogels;temperature/pH dual sensitivity;drug controlled release;biocompatibility
研究领域:
材料科学
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药学
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生物医学工程
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DOI
PubMed
高影响因子
Journal of Materials Chemistry B
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2017
·Vol. 5
·期 16
·2964-2978
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IF 4.543
Mingxing Yin,Yuling Bao,Xueqin Gao,Yupei Wu,Yu Sun,Xinyuan Zhao,Hongzhe Xu,Zhiping Zhang,Songwei Tan
A redox/pH dual-sensitive graft copolymer, poly(β-amino ester)-g-D-α-tocopherol polyethylene glycol succinate (PBAE-g-TPGS), was synthesized through a Michael-type step polymerization using disulfide linkage-containing TPGS macromonomers. Pluronic F127 (F127) and folate-F127 conjugation were introduced to prepare paclitaxel (PTX)-loaded hybrid micelles to improve their biocompatibility and serum stability and also to achieve targeted delivery. The hybrid micelles exhibited in vitro redox/pH-sensitive PTX release, enhanced cellular uptake through receptor-mediated endocytosis, and strengthened anticancer activities in both the drug-sensitive human breast cancer MCF-7 and drug-resistant MCF-7/ADR cells. P-Glycoprotein inhibition by TPGS and folate-mediated targeted delivery helped overcome multidrug resistance (MDR) and increase the therapeutic efficiency of the drug, leading to good anticancer effects in the MCF-7/ADR xenograft model. Overall, the folate-modified redox/pH-sensitive hybrid micelles provided a three-step approach to enhance anticancer activities via targeted delivery, controlled release, and depressed drug efflux; thus, these micelles may be a powerful weapon against MDR cancers in the future.
研究领域:
药物递送系统
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肿瘤学
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生物材料
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产品关联
DOI
PubMed
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
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2015
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IF 3.088
Shuang Xu,Yan Li,Zhenjie Chen,Cuilan Hou,Tong Chen,Zhigang Xu,Xiaoyu Zhang,Haixia Zhang
Mesoporous silica nanoparticles (MSNs) combining gold particles (MSNs–Au) were synthesized as nanocarriers for glutathione (GSH) and pH dual-sensitive intracellular controlled release of the anti-cancer drug doxorubicin (DOX). The MSNs were used as an adsorbent for DOX, and the ultra-small gold nanospheres (Au NPs) partly operated as gatekeepers to control the release of DOX from the pores of MSNs and as the driver of drug release in the presence of GSH due to the association between GSH and Au particles. Under different pH conditions, DOX release changed due to different levels of dissociation between the –SH group on the MSNs and the Au particles. The composition, morphology, and properties of the as-prepared composites were characterized by elemental analysis, fluorescence spectroscopy, Fourier transform infrared spectroscopy, transmission electron microscopy, nitrogen adsorption–desorption, thermal gravimetric and UV–visible spectroscopy. The in vitro release experiments showed that these smart nanocarriers effectively avoided drug leakage in the neutral media. Cytotoxicity and imaging studies also indicated that DOX-loaded Au-MSNs ( [email protected] –Au) had a significant inhibitory effect on the growth of Tca8113 cells and sustained the release rate of DOX
研究领域:
纳米技术
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癌症研究
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药物递送系统
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材料科学
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产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
·
IF 7.7
Chunwang Hu,Hongliang Wei,Hongli Chen,Bing Zhang,Wenjing Zhang,Gang Wang,Tao Guo
A temperature/pH dual sensitive hydrogel with a semi-interpenetrating network (semi-IPN) structure was synthesized through an aqueous amino-succinimide reaction between water-soluble polysuccinimide and polyethyleneimine in the presence of thermosensitive cellulose derivatives. Single-factor experiments were carried out to optimize the preparation conditions of the semi-IPN hydrogel. The swelling behavior and cytotoxicity assay of the hydrogel were tested. Finally, taking 5- fluorouracil (5-Fu) as a model drug, the release performance of the 5-Fu-loaded hydrogel was investigated. The results indicated that the swelling ratio (SR) first decreased and then increased when the pH of the solutions ascended from 2 to 10. The SR decreased with the increase in temperature. In addition, the swelling behavior of the hydrogel was reversible and reproducible under different pH values and temperatures. The prepared hydrogels had good cytocompatibility. The release behavior of 5-Fu was most consistent with the Korsmeyer-Peppas model and followed the case II diffusion. The acidic environment was beneficial for the release of 5-Fu. The preparation process of the semi-IPN hydrogel is simple and the reaction can proceed quickly in water. The strategy introduced here has great potential for application in the preparation of drug carriers.
研究领域:
材料科学
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高分子化学
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药学
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）