AUSTRALIAN JOURNAL OF CHEMISTRY
·
2015
·Vol. 68
·期 9
·1446-1454
·
IF 1.558
Haoran Yuan,Denian Li,Yan Liu,Chuanxi Xiong
Efficient synthesis and controlled modification of carbon dots (CDs) with tuneable properties on the basis of facile technical routes are of great significance for user-defined applications as well as more insightful understanding of the unique fluorescence from carbon nanomaterials. In this work, we report an improved nitric acid oxidization method towards low-cost and rapid preparation of fluorescent CDs. This is achieved by using industrial carbon black specimens as the precursor and implementing a reduced pressure distillation for the purpose of eliminating excessive acids. Unexpectedly, the product exhibits an interesting dual luminescence behaviour with tuneable characteristics that differs from all previously reported CDs. The strongest emissions at fixed or varied excitations can be simultaneously tuned from blue to green or yellow by simply prolonging the time of acid oxidization. These emissions show distinct stabilities in acid and alkaline environments, thereby making the resultant CDs very promising candidates for pH probes. It is further revealed that this simple synthesis and fluorescence tuning strategy is also applicable to CDs from other carbon blacks.
研究领域:
材料科学
·
光学
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF ENVIRONMENTAL ANALYTICAL CHEMISTRY
·
2017
·
IF 1.208
Yongli Liu,Qingxiang Zhou
In present work, fluorescent carbon dots (CDs) with an average diameter of 2.5 nm were firstly synthesised by a simple, convenient and low-cost hydrothermal method from chocolate. The obtained CDs possessed fine monodispersity and bright blue fluorescence that was strongest at an excitation wavelength of 360 nm and had a comparable quantum yield of 12% (in case of dots prepared in presence of nitric acid). The emission peak depended on the excitation wavelength in the range from 320 to 440 nm. Ionic strength had a weak effect up to 1.0 M and then no significant change was found in the range of 1.0–4.5 M. The fluorescence intensity of CDs displayed good pH adaptability and a linear dependence on the pH change in the range of pH 1.0–3.0 and pH 9.0–12.5, which have promising potentials for pH sensor.
研究领域:
材料科学
·
分析化学
✓ 已验证
产品关联
DOI
高影响因子
ANALYTICAL CHEMISTRY
·
2017
·
IF 6.32
Jingni Fu,Luning Zhang
Relying on the nanometer-thick water core and large surface area-to-volume ratio (∼2 × 108 m–1) of common black film (CBF), we are able to use a pH-sensitive dye (carboxy-seminaphthorhodafluor-1, SNARF-1) to detect ammonia and acetic acid gas adsorption into the CBF, with the limit of detection reaching 0.8 ppm for NH3 gas and 3 ppb for CH3COOH gas in the air. Data analysis reveals that fluorescence signal change is linearly proportional to the gas concentration up to 15 ppm and 65 ppb for NH3 and CH3COOH, respectively.
研究领域:
分析化学
·
环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
·
2020
·
IF 5.88
Shengmei Song,Junhui Hu,Minglu Li,Xiaojuan Gong,Chuan Dong,Shaomin Shuang
The fluorescent boron, nitrogen and sulfur co-doped carbon dots (BNSCDs) were prepared by simple hydrothermal reaction of 4-carboxyphenylboronic acid and 2,5-diaminobenzenesulfonic acid at 200 °C for 8 h. The fluorescence of the BNSCDs could be quenched by Fe 3+ based on the electron transfer between Fe 3+ and BNSCDs, so a label-free, good selectivity and high sensitivity method for Fe 3+ determination was established with linear range and LOD of 1.5–692 μmol/L and 87 nmol/L, respectively. And then the fluorescent probe was employed for detection of Fe 3+ in tap water, coal gangue, fly ash and food samples successfully. Moreover, the as-prepared BNSCDs could serve as a novel pH fluorescent probe in the range of pH 1.60–7.00, which could be attributed to the proton transfer of carboxyl groups on the surface of BNSCDs. More importantly, the pH fluorescent probe possesses fast, real-time and low toxicity, applying for intracellular pH fluorescence imaging in HIC, HIEC, LO2 and SMMC7721 cells. In view of its simplicity, timely response and outstanding compatibility, the as-fabricated BNSCDs show the potential applications in water quality and solid waste monitoring, food detection, real-time measuring of intracellular pH change in vitro.
研究领域:
分析化学
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生物医学工程
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环境科学
✓ 已验证
DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2022
·
IF 9.221
Lixia Guo,Xueyun Zhang,Danning Wen,Lei Ding,Yan Niu,Lihong Li,Wen Liu,Haipeng Diao,Liheng Feng
Accurate measurement of pH is of great significance in the research of biology and medicine sciences. Cell is the basic unit of living organism and the proper pH of cytoplasm and organelles such as lysosome is the precondition to maintain its function. Alteration of pH may impair the normal process of cells and lead to occurrence of diseases. Sensitively sensing the pH of cytoplasm and organelles is of great value for biomedical research. Due to the complexity of biological microenvironment , it is still challenging to simultaneously detect the pH changes of cytoplasm and lysosome. Here, we reported a ratiometric pH probe with NIR fluorescence termed as PCHC, which realized sensitive cytoplasmic and lysosome pH detection. The probe was prepared by connecting coumarin with dicyanmethylene-4H-pyran via amidation reaction, and displays large Stoke-shift, good biosafety and pH selectivity. After entering the cell, the probe shows blue in cytoplasm and NIR fluorescence in lysosome due to respective pH. The ratio of blue and NIR fluorescence signal can be served as indicator to monitor pH change of cytoplasm and lysosome simultaneously, which has potential application for investigation of pH alteration related diseases.
研究领域:
生物医学
·
细胞生物学
✓ 已验证
DOI
高影响因子
CHEMICAL PHYSICS
·
2018
·
IF 1.707
Jingni Fu,Luning Zhang
The protonation/deprotonation equilibrium of a fluorescent pH probe (carboxy-seminaphthorhodafluor-1, SNARF-1) within the nanoscale water layer confined in common black films (CBFs) has been studied. We find that SNARF-1 molecules feel a more acidic environment in CBFs than when they are in the bulk micellar solution, using the base/acid peak area ratio of the dye to indicate its microenvironment pH. Three surfactants are used to study the dependence of the pH drop versus charge: cationic (cetyltrimethylammonium bromide, CTAB), anionic (sodium dodecylsulphate, SDS) and nonionic (Triton X-100) species. The decrease of CBFs pH versus the pH of the micellar solution is the following: ΔpH ≈ 1.5 for CTAB (pH: 7.0–9.0), ΔpH ≈ 0.8 for SDS, and ΔpH ≈ 0.4 for Triton X-100. With the addition of electrolyte in CBFs, we observe large decrease the amplitude of the pH anomaly, thus suggesting an electrostatic origin of the pH change at nanoscale environment.
研究领域:
生物化学
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材料科学
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分析化学
✓ 已验证
产品关联
DOI
高影响因子
Advanced Healthcare Materials
·
2024
·
IF 10
Da Huang,Jiahao Du,Fang Luo,Gang He,Minglang Zou,Yongming Wang,Zhenyu Lin,Decheng Wu,Zuquan Weng
Hydrogel dressings capable of infection monitoring and precise treatment administration show promise for advanced wound care. Existing methods involve embedd ingorganic dyes or flexible electronics into preformed hydrogels, which raise safety issues and adaptability challenges. In this study, an injectable hydrogel based smart wound dressing is developed by integrating food-derived anthocyanidin as a visual pH probe for infection monitoring and poly( L -lactic acid) microcapsules as ultrasound-responsive delivery systems for antibiotics into a poly(ethylene glycol) hydrogel. This straightforwardly prepared hydrogel dressing maintains its favorable properties for wound repair, including porous morphology and excellent biocompatibility. In vitro experiments demonstrated that the hydrogel enabled visual assessment of pH within the range of 5 ∼ 9.Meanwhile, the release of antibiotics could be triggered and controlled by ultrasound. In vivo evaluations using infected wounds and diabetic wounds revealed that the wound dressing effectively detected wound infection by monitoring pH levels and achieved antibacterial effects through ultrasound-triggered drug release. This led to significantly enhanced wound healing, as validated by histological analysis and the measurement of inflammatory cytokine levels. This injectable hydrogel-based smart wound dressing holds great potential for use in clinical settings to inform timely and precise clinical intervention and in community to improve wound care management.
研究领域:
生物医学工程
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材料科学
·
药学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ANALYST
·
2020
·Vol. 145
·期 19
·6270-6276
·
IF 3.978
Haiyan Cao,Mingjie Tang,Xin Wang,Wenbing Shi
Recent years have seen molybdenum oxide quantum dots (MoOx QDs) as a booming material due to their attractive physical and chemical properties. However, there is still a large demand for MoOx QDs with long-wavelength emission by a facile strategy but these are more challenging to obtain. Herein, we rationally designed and successfully prepared nitrogen and phosphorus co-doped green emitting MoOx QDs (N,P-MoOx QDs) through a microwave-assisted rapid method. They exhibit a maximum emission at 500 nm under a 430 nm excitation. Moreover, by controlling their sizes in the process, we find that such a strategy enables the tuning of the emission color of N,P-MoOx QDs from green to blue. N,P-MoOx QDs show a significant fluorescence response to pH changes, and also display pH-sensitive near-infrared localized surface plasmon resonance (LSPR) at 866 nm. An effective and simple pH probe with a dual-signal response is achieved using N,P-MoOx QDs. As environmental sensors, N,P-MoOx QDs can be applied for sensitive detection of the concentrations of permanganate and captopril, offering the linear range from 0.08 to 25 μM and 0.1 to 31 μM, respectively. Benefitting from the effect of doping nitrogen and phosphorus, the probe could detect a wide range of pH changes (2–9) and is endowed with superior biocompatibility. Further, it is successfully used to “see” the intracellular pH variation by fluorescence confocal imaging. These findings not only demonstrate the achievement of a promising multifunctional probe for biosensing and environmental detection, but also pave the way for the fabrication of transition metal oxide QDs with tunable optical properties.
研究领域:
材料科学
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生物医学工程
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环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of the American Chemical Society
·
2024
·
IF 14.4
Weiwei Ma,Yuxin Wang,Ruizhao Wang,Xin Fan,Sicong Ma,Yuchen Tang,Zhihui Ai,Yancai Yao,Lizhi Zhang,Tingjuan Gao
The interaction between a solid and water at their interface, especially proton transfer, impacts molecular-scale catalysis, macroscopic environmental science, and geoscience. Although being highly desired, directly probing proton transfer between a solid and water is a great challenge, given the subnanometer to nanometer scale of the interface. The fundamental challenge lies in the lack of a measurement tool to sensitively observe local proton concentration without introducing an exogenous electrode or nanoparticle with a minimum size of tens of nanometers. Here, we demonstrate an azo-enhanced Raman scattering strategy to design a 2 nm long small-molecule pH probe with a chelating group anchoring to the solid surface. Empowered by the intramolecular Raman enhancing sensitivity, the probe directly observes proton transfer between water and nanoscale zero-valent iron (nZVI), a famous environmental material for pollution control. This molecular-scale interfacial probing methodology offers a powerful tool to pave the way for advanced environmental and geochemical discernment and management.
研究领域:
环境科学
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材料科学
·
表面化学
✓ 已验证
DOI
PubMed
高影响因子
TALANTA
·
2019
·
IF 4.916
Qi Zhuang,Xiaojing Si,Li Li,Hongyan Zeng,Yaping Ding
Fluorescent pH probes are promising for both in vitro and in vivo pH detections in chemical and biochemical systems. Previously, the multi-color and whole cell pH sensing is a challenge for conventional fluorescent nanomaterials . In this work, we report an N, S co-doped carbon dots (N, S-CDs)-based fluorescent pH probe that can response to different incident light with tunable wavelength. The emission wavelength is tunable and correlated to the excitation wavelength, enabling self-adaptive multi-color sensing. The N, S-CDs was synthesized by a one-step hydrothermal method utilizing glucose, ammonium persulfate and ethylenediamine as precursors. The fluorescence of N, S-CDs shows a good linear relationship against pH values from 3.0 to 10.0 with a linear correlation coefficient of 0.996. The good biocompatibility and small size fulfill the demand of whole cell intracellular imaging. We have demonstrated that the N, S-CDs have successfully applied in HepG2 cells for the self-adaptive multi-color imaging.
研究领域:
材料科学
·
生物化学
·
细胞生物学
·
光学成像
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
·
2022
·Vol. 23
·期 11
·6259
·
IF 6.208
Tianyu Li,Haijun Pang,Qiong Wu,Meifen Huang,Jiajun Xu,Liping Zheng,Baoling Wang,Yongfeng Qiao
Optical signals of pH probes mainly driven from the formation or rupture of covalent bonds, whereas the changes in covalent bonds usually require higher chemical driving forces, resulting in limited sensitivity and reversibility of the probes. The exploration of high-performance pH probes has been a subject of intense investigation. Herein, a new pH probe has been developed, with optical property investigation suggesting the probe has excellent signal-to-noise ratio, and fluorescence intensity shows exponential growth, combined with a visible color change, as pH increased from 5.1 to 6.0; Moreover, the probe has outstanding stability and reversibility, with more than 90% of the initial signal intensity remaining after 30 cycles. In order to better understand the special fluorescence behavior of the reported probe, the non-halogenated isomer is introduced for comparison, combined with the results of structural analysis, quantitative calculation and optical experiments, and the possible mechanism of the special supramolecular aggregation-caused quenching effect induced by the halogen atom is discussed.
研究领域:
化学
·
材料科学
·
光学
✓ 已验证
DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2018
·Vol. 42
·期 16
·13479-13485
·
IF 3.201
Li Fan,Ming Nan,Jinyin Ge,Xiaodong Wang,Bo Lin,Wenjia Zhang,Shaomin Shuang,Chuan Dong
A novel quinoline/benzothiazole pH probe (E)-2-(2-(quinolin-4-yl)vinyl)benzothiazole (BTVQ) was facilely synthesized. BTVQ exhibits remarkable emission response to pH and can image pH changes within the extreme acidity range of 3.0–3.8 with a pKa of 3.52. Moreover, BTVQ displays a notably large Stokes shift of 110 nm, which can reduce the excitation interference. BTVQ was successfully applied in HeLa cells and E. coli cells, suggesting that BTVQ can be employed as one of the few lysosome specific probes for imaging acidic intracellular pH changes, especially under extreme-acidity conditions in bacteria.
研究领域:
化学
·
细胞生物学
·
生物成像
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）