Asian Journal of Pharmaceutical Sciences
·
2025
·
IF 11.9
Qinying Chen,Xinao Liu,Zijin Tan,Zhihao Liu,Zijie Qiu,Yerong Xiong,Jiasheng Tu,Yanping Wu,Chunmeng Sun
Antitumor nanomedicines are usually decorated with ligands to achieve multiple functions, such as focused targeting, tissue penetration, and enhanced cellular uptake. However, a single ligand with multiple functions is generally preferred for use in practice. Herein, a versatile peptide, (HE) 10 G 5 R 6 GDK (HE-RK), was engineered by integrating several motifs in a single sequence, including a masking segment (HE), a flexible linker (G 5 ), and a tumor-penetrating head (RK), which comprised a cell-penetrating peptide (R 6 ) and a C-end Rule peptide (RGDK). The RK moiety in HE-RK was sequentially activated following the gradual charge reversal of HE to facilitate the accumulation of its cargos in deep tumor tissue and the cytosol of cancer cells. Moreover, in our study, polymer micelles conjugated with the HE-RK peptide (PM-HE-RK) showed superior cellular internalization at pH 6.5 compared to pH 7.4 in vitro , as well as extended blood circulation time and improved tumor targeting and penetration in vivo . Furthermore, the paclitaxel (PTX)-loaded micelles (PTX/PM-HE-RK) demonstrated considerable antitumor efficacy, that is, an 81.48% tumor inhibition rate in the 4T1 mouse model. Overall, the construction of this all-in-one multisegment peptide presents a synergistic and complementary approach to advancing multifunctional peptide ligand design.
研究领域:
生物医学工程
·
癌症治疗学
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Processes
·
2025
·Vol. 13
·期 5
·1525
·
IF 2.8
Yue Chen,Xiaofei Guan
Recycling the positive electrode materials of spent Li-ion batteries is critical for environmental sustainability and resource security. To facilitate the attainment of the goal, this study presents a novel approach for recovering valuable metals from positive electrode materials of spent lithium-ion batteries (LIBs) in an H-shaped cell containing aqueous NaCl electrolyte. The process employs hydrochloric acid that could be derived from the chlorine cycle as the leaching agent. The electrolytic device is engineered to generate a high pH gradient, thereby enhancing the leaching of metal elements and eliminating the requirement for external acid or base addition. This green recycling approach adheres to the principles of a circular economy and provides an environmentally friendly solution for sustainable battery material recycling.
研究领域:
环境科学
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材料科学
✓ 已验证
产品关联
DOI
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2018
·
IF 13.325
Peng Li,Gong Jinghua,Ma Jinghong
Electro-responsive hydrogels have attracted great attentions because the electric stimuli is easy to be applied and controlled. Thus, it is expected to generate electro-responsive hydrogel fiber to improve electro-response rate. In this paper, graphene oxide/hydrolyzed polyacrylamide/sodium alginate (GO/HPAM/SA) hydrogel fibers were prepared by microfluidic spinning. The structure and morphologies of hydrogel fibers were characterized by FTIR and SEM. The electro-response behaviours were also studied. The results indicate that GO/HPAM/SA hydrogel fibers exhibit bending deformation in an electric field. In Na 2 SO 4 solution, the hydrogel fibers first bend toward the cathode, and then bend toward the anode. It is suggested the bending of the hydrogel fibers is caused by two major factors, one is the osmotic pressure difference, another is the pH gradient induced by electrochemical reactions. Keywords Electro-responsive hydrogel fiber Bending behaviour Osmotic pressure difference pH gradient
研究领域:
材料科学
·
生物工程
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
Yuan-Ju Tang,Shu-Jie Zhang,Zi-Tao Zhong,Bin Zhang,Wen-Ming Su,Guo-Ping Wang,Yuan-Di Zhao
The construction of porous ion channels with ion current rectification (ICR) at the submicron scale has great significance for the development of large-area bionic ion channel devices. In this manuscript, one kind of heterogeneous membrane with asymmetric composition, geometry and wettability was prepared by simple drop-coating of the neutral hydrophobic conducting polymer precursor and in-situ thermal polymerization on cylindrical submicron scale anodic aluminum oxide channels (D≈269 nm) at 150 °C. ICR in the submicrochannel heterogeneous membrane was successfully achieved due to the asymmetric charge distribution induced by asymmetric pH gradient. Furthermore, the rectification ratio ( R ic : 1.6 ∼ 42.8) could be effectively regulated by multiple drop-coating, the electrolyte concentration (0.01 mM ∼ 1 M) and pH gradient (3 ∼ 11). Finally, through the permeation experiment of anionic dye and cationic dye, the mechanism of the synergistic effect of surface charge and electrophoresis on the ion selectivity and ICR was discussed, and it was successfully applied to the directional and on-demand transport of anionic and cationic ions under the regulation of pH gradient and voltage driving. It has important potential applications in the treatment of pollutants, the purification of water and energy conversion etc.
研究领域:
生物物理学
·
材料科学
·
仿生学
✓ 已验证
DOI
高影响因子
Current Drug Delivery
·
2019
·Vol. 16
·期 10
·940-950
·
IF 1.645
Yu Jiandong,Chen Zhi,Yin Yan-zhi,Tang Chaoyuan,Hu Enying,Zheng Shuang,Liu Qi,Xiong Yang
Background: In this study, a liposomal gel based on a pH-gradient method was used to increase the skin-layer retention of monocrotaline (MCT) for topical administration. Methods: Using the Box-Behnken design, different formulations were designed to form liposome suspensions with
optimal encapsulation efficiency (EE%) and stability factor (KE). In order to keep MCT in liposomes and accumulate in skin slowly and selectively, MCT liposome suspensions were engineered into gels. Results: A pH-gradient method was used to prepare liposome suspensions. The optimal formulation
of liposome suspensions (encapsulation efficiency: 83.10 ± 0.21%) was as follows: MCT 12 mg, soybean phosphatidyl choline (sbPC) 200 mg, cholesterol (CH) 41 mg, vitamin E (VE) 5 mg, and citric acid buffer solution (CBS) 4.0 10 mL (pH 7.0). The final formulation of liposomal gels consisted
of 32 mL liposome suspensions, 4.76 mL deionized water, 0.40 g Carbopol-940, 1.6 g glycerol, 0.04 g methylparaben, and a suitable amount of triethanolamine for pH value adjustment. The results of in vitro drug release showed that MCT in liposomal gels could be released in 12 h constantly in
physiological saline as a Ritger-Peppas model. Compared with plain MCT in gel form, liposomal MCT in gel had higher skin retention in vitro. Conclusion: In this study, liposomal gels were formed for greater skin retention of MCT. It is potentially beneficial for reducing toxicities of
MCT by topical administration with liposomal gel.
研究领域:
药剂学
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皮肤科学
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生物医学工程
✓ 已验证
DOI
PubMed
高影响因子
Nanoscale
·
2017
·Vol. 10
·期 3
·1119-1128
·
IF 7.367
Yu Wu,Hongyun Ji,Feng Yang,Yan Meng,Yujue Wang,Jianyuan Dai,Haisheng Ren,Guangqun Tan,Dan Xiao
In this work, we report a method for the fabrication of a functional free-standing graphene membrane (FFGM) with high mechanical strength, enlarged interlayer spacing and ion channels for zwitterionic ions separation. To obtain the FFGM, the anionic dye Eosin Y (EY) was introduced into a graphene oxide (GO) and hydroquinone (HQ) mixture to prepare functional graphene-based membranes on Cu foil using simply a drop-casting method. In comparison with a GO membrane, the molar flux and the mechanical strength of the FFGM were dramatically increased. The FFGM was then equipped on custom-built glass reservoirs for zwitterionic amino acids (AAs) separation based on the inner pH gradient, which was formed by controlling H+ and OH− (in the feed and receiver solution) migration in rGO/GO sheets via an external electric field. With the help of the inner pH gradient and external electric field, AAs could change their charge behaviors. The ionized AAs transport through the FFGM and finally separation was realized.
研究领域:
材料科学
·
生物化学
✓ 已验证
DOI
PubMed
高影响因子
ANALYST
·
2021
·Vol. 146
·期 22
·6815-6821
·
IF 4.616
Yuan-Ju Tang,Shu-jie Zhang,Zi-Tao Zhong,Wen-Ming Su,Yuan-Di Zhao
Solid-state nanochannels have attracted considerable attention for their similar ion transport properties to biological ion channels. The construction of porous ion channels with good stability at the submicro/micrometer scale is very beneficial to develop large-area ion channel devices. In this manuscript, based on in-situ thermal crosslinking of a small organic molecule containing triphenylamine and styrene groups, we construct a heterogeneous membrane with asymmetrical charge and wettability on cylindrical anodic aluminum oxide (AAO) channels (D ≈ 319 nm). This heterogeneous membrane has typical ion current rectification characteristics with a high rectification ratio of 36.9 and good stability. This work provides an effective strategy for the construction of submicrochannel heterogeneous membranes and also broadens the application range of bionic ion channels.
研究领域:
材料科学
·
仿生学
✓ 已验证
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
Haixin Tan,Bin Chen,Meihuan Liu,Jiamiao Jiang,Juanfeng Ou,Lu Liu,Fei Wang,Yicheng Ye,Junbin Gao,Jia Sun,Fei Peng,Yingfeng Tu
Light-driven micro/nanomotors have made enormous progress in various practical applications owing to their excellent controllability and programmability. However, it is still far from real intellectualization. Herein we demonstrate the successful fabrication of hollow cuprous oxide (Cu 2 O) micromotors with autonomous phototaxis reversal behavior by in-situ sensing the local pH change of surrounding environment without altering the lighting direction. The fabricated motors exhibit excellent and controllable propulsion under low-strength visible light illumination (1100 LUX) due to faster charge separation between different facets of the crosslinked polyhedral Cu 2 O microstructures. Intriguingly, our Cu 2 O micromotors are possible to respond smartly to the local pH gradient and reverse from negative to positive phototaxis, therefore the motors are capable of evacuating automatically after mission. We envision that such adaptive micromotor with great intellectualization via responding autonomously to the local stimuli shows great promise in various applications especially biomedical scenarios.
研究领域:
纳米技术
·
生物医学工程
·
材料科学
·
机器人技术
✓ 已验证
DOI
高影响因子
TALANTA
·
2017
·
IF 4.162
Qian Liu,Chaoping Xu,Heng Liang
We developed novel laser carved micro-crack (LCC) paper-based channels to significantly accelerate the liquid flow without an external pump. For the aqueous solutions they increased the flow velocity 59 times in 16% laser power-8 micro-cracks-LCC channel compared with it in solely-printed channels. All experimental data from both LCC and solely-printed channels were well-fitted by the time-distance quadratic trinomial that we developed on laser power and micro-crack number. We designed and fabricated T-junction microstructures of LCCs. Further, the microfluidic paper-based analytical device (μPAD) of LCC on dye mixing gradient and pH gradient were developed with the characteristics, fast self-acting transportation and high-performance mixing of liquid flows. In the dye mixing gradient the time cost was reduced from 2355 s in the solely-printed one to only 123 s in the five-stage of this LCC-μPAD. It was useful for quick and long-distance transferences through the multiple units of μPADs. Certainly, this LCC-μPAD was inexpensive, disposable, portable and applicable to resource-limited environments.
研究领域:
生物医学工程
·
微流控技术
·
分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2025
·
IF 5.4
Shuai Yang,Qiang He,Xiankun Lin
Inspired by the chemotaxis of natural organisms that responds to environmental stimuli, chemotactic micro-/nanomotors have been developed toward a certain chemotactic cue. However, the chemotaxis of nanomotors towards the complex environment with multiple chemical gradients is highly desired. Here, we report a glucose-powered Janus mesoporous silica nanomotor exhibiting positive, chemotactic behavior toward regions rich in glucose and low pH. The nanomotors are prepared through partially coating gold onto mesoporous silica nanoparticles and then immobilizing glucose oxidase (GOx) onto the gold patch. Due to the enzymatic catalytic decomposition, the nanomotors propelled by self-diffusiophoresis exhibit the motion behaviors dependent on the glucose concentration and pH. The translation diffusion coefficient of the nanomotors is enhanced with increasing the glucose concentration. The translation diffusion coefficient reaches the maximum value at pH 5.5 when adjusting the pH of the glucose solution. In the presence of either the concentration gradient of glucose or the gradient of pH or both, the nanomotors exhibit positive chemotactic behaviors. This result indicates that multiple chemotaxis can be involved when enzyme-powered nanomotors move towards a complex environment, which will enhance the design of nanomotors for the advanced applications such as actively targeted drug delivery.
研究领域:
纳米技术
·
化学工程
·
生物物理学
·
材料科学
·
酶催化
✓ 已验证
产品关联
DOI
高影响因子
ANALYTICA CHIMICA ACTA
·
2019
·
IF 5.256
Yu Cai,Ji-Cheng Niu,Yu-Qi Liu,Xin-Li Du,Zhi-Yong Wu
Paper-based analytical device (PAD) has received more and more attention in the field of point-of-care test (POCT) due to its low cost, portability and simple operation. Sensitivity and selectivity are two important aspects in clinical diagnostic analysis. However, low sensitivity of a PAD limits its wider application for POCT. Here we introduced a PAD that can clean and enrich the protein content from salty media with both electric field (E) and pH gradient (double E/pH gradients), with which 100-fold enrichment effect could be achieved within 70 s as demonstrated by fluorescein isothiocyanate labeled bovine serum albumin (FITC-BSA) from artificial urine media. With post staining of the protein stacking band with bromophenol blue (BPB), selective colorimetric detection of human serum albumin (HSA) was achieved simply with smartphone camera in the clinically significant range of 10–300 mg‧L −1 (R 2 = 0.99) with a limit of detection (LOD) of 4.9 mg‧L −1 . Detection of microalbuminuria (MAU) of diabetic patients was demonstrated with this method without difference (ɑ = 0.01) to that by the clinical method (immunoturbidimetry). This work demonstrated the potential of this PAD method in online sample pretreatment and detection of target component from complex physiological samples.
研究领域:
分析化学
·
生物医学工程
·
临床诊断
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Microfluidics and Nanofluidics
·
2022
·Vol. 26
·期 11
·1-9
·
IF 3.09
Niu Bing-Su,Wang Yu-Hang,Lv Shuang,Yang Yu,Fang Fang,Song Yan-Yan,Wu Zhi-Yong
Charged components can be effectively separated and enriched based on ion concentration polarization (ICP) effect for sample clean up and enhancement of detection sensitivity in analytical chemistry. Concerning the role of electrolyte, current studies on electrokinetic stacking with ICP mainly focused on the ionic strength, and the knowledge about the type of supporting electrolyte (SE) is still poor. In this study, the significance of acid–base property of SE was systematically investigated based on an ICP interface established on a paper fluidic device with ion exchange membrane. Using colored ion probes for visualization of the effects, the ion depletion zone as the working area was applied for electrokinetic stacking. It has been shown that, besides the proper electroosmotic flow and ionic strength decided by neutral salt, the acid–base property of SE plays an important role for a successful stacking with ICP. The guideline for SE selection was proposed, and the mechanism was well explained by correlating the water dissociation effect and electric field/pH gradient (double gradients) at the ion depletion zone. This rule proposal is substantial for the design and operation of electrokinetic enrichment and separation of targeted species using ICP effect.
研究领域:
分析化学
·
电化学
·
微流控技术
·
分离科学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）