INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
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IF 8.5
Miaomiao Chen,Meng Zhou,Yunyun Wang,Caihong Mao,Shujie Pang,Ting Meng,Xudong Yang
To address the challenges associated with the storage and application of traditional carbon dot (CDs) solutions, this study introduces a cyan fluorescent carbon dot-based hydrogel (CDs-SCH). The hydrogel was synthesized by integrating cyan fluorescent CDs, derived from penicillamine and m -phenylenediamine, with carboxymethylcellulose (CMC) and sodium alginate (SA), which was then mixed with acrylamide (AM). The resulting CDs-SCH hydrogel was extensively characterized, focusing on its morphology, chemical structure, and fluorescence behavior. The fluorescence intensity of the hydrogel was enhanced by 3.23 times compared to the original CDs. The fluorescence response of the CDs-SCH hydrogel to pH variations was examined, demonstrating its capability to visually monitor the freshness of aquatic products such as fish and shrimp. Furthermore, Al 3+ and Ag + ions were found to significantly modulate the fluorescence, with Al 3+ enhancing and Ag + quenching the fluorescence, displaying reliable detection limits and linearity. The hydrogel's ability to detect glutathione (GSH) via Ag + reduction to Ag was also explored. Additionally, the hydrogel exhibited stable Al 3+ adsorption, with the process following pseudo-second-order kinetics and the Langmuir adsorption model. As a versatile and responsive material, the CDs-SCH hydrogel holds potential for applications in intelligent food packaging and environmental ion detection.
研究领域:
材料科学
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环境科学
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食品科学
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产品关联
DOI
PubMed
高影响因子
Nanoscale
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2015
·Vol. 7
·期 48
·20743-20748
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IF 7.394
Zhe Wang,Yuexiang Lu,Hang Yuan,Zhonghua Ren,Chao Xu,Jing Chen
Developing a simple synthesis method and expanding the application of carbon dots have attracted increasing attention. In this report, we have developed a facile method to synthesize fluorescent carbon dots (CDs) with the assistance of atmospheric-pressure microplasma. The CDs could be produced within a few minutes with no need of high temperature, external energy input, and multistep procedures. The as-prepared CDs had a relatively uniform size of approximately 2.3 nm. The FTIR spectrum and the XPS analysis showed that carbonyl groups and amide groups exist on the surface of CDs. The CDs showed bright blue luminescence and high stability in high salt concentration and low pH without further modification. A pH-dependent PL behavior was observed and could be applied for pH sensing in the range of 3–14. Moreover, the CDs could be utilized as a reagent capable of detecting U(VI) with a low detection limit and high selectivity.
研究领域:
材料科学
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分析化学
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DOI
高影响因子
RSC Advances
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2020
·Vol. 10
·期 61
·36971-36979
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IF 3.119
Hua Tian,Yongcheng Dai,Wenzhe Fu,Haifang Liu,Mengting Li,Meiyuan Lv,Xueqiong Yin
In this work, a multifunctional ratiometric fluorescence (FL) nanohybrid (CSCDs@DC) was synthesized from chitosan based carbon dots (CSCDs) and dansyl chloride (DC) at room temperature. The CSCDs@DC revealed strong FL intensity, great stability and excellent anti-photobleaching properties. Herein, CSCDs@DC was responsive to pH value in the range of 1.5–4.0 and exhibited color-switchable FL properties between acidic and alkaline environments. In addition, CSCDs@DC showed good selectivity and sensitivity towards Fe3+ ions. A good linear relationship for the Fe3+ ion detection was obtained in the range from 0 μM to 100 μM, with a detection limit of 1.23 μM. What's more, CSCDs@DC can be used as a fluorescent ink. It expressed superior optical properties after 3 months of storage or continuous exposure to UV light for 24 h. This study suggested that CSCDs@DC had potential in the detection of pH and metal ions, as well as showing promising application in the anti-counterfeiting field.
研究领域:
材料科学
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分析化学
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生物医学工程
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DOI
高影响因子
Journal of Materials Chemistry C
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2019
·Vol. 7
·期 9
·2563-2569
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IF 6.641
Chao Xia,Mengmeng Cao,Jinfeng Xia,Guohong Zhou,Danyu Jiang,Dafeng Zhang,Jing Wang,Huili Li
Carbon dots (CDs), as a new kind of fluorescent pH nanoprobe, have attracted significant attention due to their favorable optical properties and excellent environmental friendliness. However, a real ratiometric and self-calibrating fluorescent pH nanoprobe based on intrinsic dual-emission CDs (DECDs) still remains scarce. In this study, we reported a kind of intrinsic DECDs for ratiometric fluorescence pH sensing. Interestingly, the two emission bands at 393 and 580 nm from the DECDs simultaneously display strong pH-dependence but with an adverse variation trend. The ratio of the intensity of 393 and 580 nm matches well with an empirical function against pH in the range from 2.2 to 8.0, and further, an excellent linear relationship is presented in an acidic environment with a responsive pH range of 2.2–4.0. Moreover, the rapid response time (<1 min), high sensitivity, good reversibility and pinpoint accuracy (±1.0%) for pH sensing reveals that the as-prepared DECDs can act as excellent ratiometric luminescent nanoprobes for pH detection. We hope that this study will offer new possibilities for expanding the applications of luminescent CDs in chemical sensing, biomedicine and food safety.
研究领域:
化学
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生物医学
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食品安全
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DOI
高影响因子
MICROCHEMICAL JOURNAL
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2024
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IF 4.9
Yi Tian,Yunlong Yue
To improve the photoluminescence (PL) and increase photostability of carbon dots (CDs), phosphorus doped CDs with bright green emitting were prepared using (NH 4 ) 2 HPO 4 and m-phenylenediamine (MPD), and terephthalic acid (TA) via a solvothermal synthesis. Compared to undoped CDs (M−CDs), the PL efficiency of P-doped sample (M−6 %P-CDs) created using optimized conditions was improved from 55.1 to 73.9 %. These bright CDs were incorporated in films to test the stability, in which the photostability in liquid and polymer films were improved by 6 and 37 %, respectively. Namely, it is found that P affected the functional groups of on the surface and inside CDs. Phosphorus promoted the dehydration condensation reaction of precursors, increased the structural defects of the CDs, separated the sp 2 structural domains, and retained more oxygen-containing functional groups. In the case of o-phenylenediamine (OPD) instead of MPD, the PL efficiency of P-doped CDs was decreased. This is ascribed to P impeding the polymerization process of OPD. These CDs were used for pH and Cr(VI) ion sensors. P-doping improved the sensitivity of CDs to pH and Cr(VI). The pKa value of sample M−6 %P-CDs was 8.32 which was much lower compared with undoped one (∼1.97). Moreover, P-doped CDs revealed significantly enhanced sensitivity response to Cr(VI). The detection range and detection limit of M−6 %P-CDs for Cr(VI) was 1–130 μM and 0.59 μM, respectively. These results are crucial for the preparation and applications of CDs.
研究领域:
材料科学
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分析化学
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产品关联
DOI
高影响因子
ANALYTICA CHIMICA ACTA
·
2025
·
IF 6
Meihui Gao,Xianjing Zhang,Shiqi Li,He Gao,Xinyu Li,Dongyuan Xu,Longbin Xu
Background Wearable pH sensors have emerged as promising tools for real-time health monitoring, particularly for sports and clinical applications, due to their ability to monitor key physiological indicators such as sweat pH. Sweat analysis provides valuable insights into metabolic processes and physical exertion. However, the development of flexible, stable, and highly sensitive sensors for accurate sweat pH detection remains a challenge. Conductive polymer such as polyaniline (PANI), have gained attention due to their unique properties, but further improvements in mechanical flexibility and sensor performance are needed to fully realize their potential for wearable biosensing applications. Results We present a boric acid-functionalized PANI-ABA/PA hydrogel, synthesized via electrochemical deposition, where boric acid plays a crucial role in crosslinking the rigid PANI material into a flexible, porous grid structure. This crosslinking improves the mechanical properties of the hydrogel while enhancing its ion-exchange capacity, leading to greater sensitivity and selectivity for H + ions. PANI-ABA/PA hydrogel exhibits super-Nernstian behavior (77.80 mV pH −1 ) across the physiological pH range (3.00–10.00), with rapid response times, minimal temperature drift, and excellent repeatability. Moreover, the hydrogel exhibits outstanding antifouling properties, ensuring consistent performance even in dynamic environments. Real-time human subject testing confirms the sensor's ability to accurately monitor sweat pH during physical activity, providing reliable and real-time data. These results highlight the promising potential of the PANI-based hydrogel for wearable biosensors in health monitoring. Significance and novelty This study highlights the role of boric acid in facilitating the formation of a crosslinked PANI-based grid structure, which improves the sensor's performance in wearable applications. Enhanced sensitivity, stability, and mechanical flexibility make this smart wearable sensor a promising candidate for continuous, non-invasive health monitoring. It opens new opportunities for real-time athletic performance tracking, personalized healthcare, and disease diagnostics, positioning it as a leading technology for future wearable health-monitoring systems.
研究领域:
生物医学工程
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材料科学
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可穿戴设备
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产品关联
DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
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2017
·
IF 5.401
Xin Zhang,Ke Jiang,Huajun He,Dan Yue,Dian Zhao,Yuanjing Cui,Yu Yang,Guodong Qian
A fluorescent pH sensor based on post-synthetically modified nanoscale UiO-67-bpydc by encapsulating Eu 3+ cations in the pores was fabricated. The Eu 3+ incorporated sample (Eu 3+ @UiO-67-bpydc) shows excellent luminescence due to the sensitization and protection provided by the parented framework. Subsequently, Eu 3+ @UiO-67-bpydc was developed as a pH sensor. Eu 3+ @UiO-67-bpydc shows good chemical resistance to both acidity and alkalinity solutions with pH ranging from 1.06 to 10.99, which makes it potentially useful for wide-range pH sensor. In addition, cycling experiments have demonstrated the utilizability of the sensor. The MTT analysis shows that Eu 3+ @UiO-67-bpydc possesses favourable biocompatibility. Furthermore, fluorescence imaging of Eu 3+ @UiO-67-bpydc in PC12 cells was also performed to test its feasibility in vivo. Given its exceptional stability and pH-dependent fluorescent intensity, the fluorescent probe should be a promising candidate for application in fluorescent pH sensing in vitro and in vivo.
研究领域:
材料科学
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生物医学工程
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分析化学
✓ 已验证
DOI
高影响因子
REACTIVE & FUNCTIONAL POLYMERS
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2018
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IF 2.975
Lei Lei,Hengchang Ma,Jiawei Lv,Tao Wang,Yuan Yang,Pei Yin,Ziqiang Lei,Yanfang Qin,Yucheng Ma,Wenhuan Yao
Materials hybrided by organic and inorganic partners via chemical bonds formation are able to display stable and multi-functional behaviors. Then, the versatile sensing platform could be established depending on their specific chemical and physical properties. In this research paper, we prepared the fluorescence materials (POSS-PDB and POSS-NTB) by a simple method. Among of them, POSS-NTB was verified as a mesoporous material with a narrowed pore diameter around 17 nm and the large Brunauer-Emmett-Teller (BET) surface area of 227 m 2 /g. Then, the solid powder of POSS-NTB was selected and evidenced as effective gas sensor toward CO 2 , N 2 and O 2 at 273 K under 1 atm pressure. Additionally, these fluorescence materials could be successfully applied as a pH sensor in the solution phase. Through combining biocompatible POSS and fluorescent molecules, POSS-NTB could enter into the cells and aggregate in the cytoplasm successfully.
研究领域:
材料科学
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生物医学
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化学
✓ 已验证
产品关联
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
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2014
·
IF 3.84
Yanling Feng,Yufei Liu,Chen Su,Xinghu Ji,Zhike He
Silicon nanodots (SiNDs) are currently appealing to extensive studies due to their low toxicity and unique optical and electrical properties. In this work, we obtained label-free SiNDs via a facile hydrothermal method. The approach offers advantages in terms of cheap reactants, easy operation and a short time. The quantum yield (QY) of the SiNDs is up to 32.8%, and the as-prepared nanoparticles exhibit strong fluorescence (FL), higher photostability and obviously longer FL lifetime. More importantly, these label-free SiNDs can be used as a highly sensitive pH sensor, which FL respond rapidly to pH fluctuations and reveal a good linear relationship. Also, a superior pH-reversibility was demonstrated. Different salt ions show a little influence on the pH-responsive behavior. The pH of real water samples were tested on the basis of the proposed SiNDs sensor and the results are satisfactory. Further, traditional SiNDs with Si H or Si C surfaces make them less water-soluble or sensitive to the pH. Whereas, our SiNDs feature amino-terminated surface and these amino groups are conducive to the pH sensitivity. In a word, this new, cheap, low-toxic, and effective fluorescent pH sensor based on label-free SiNDs would be a promising candidate in biological field.
研究领域:
生物化学
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材料科学
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分析化学
✓ 已验证
产品关联
DOI
高影响因子
SENSORS
·
2018
·Vol. 18
·期 10
·3195
·
IF 2.475
Jianxin Zhang,Lei Zhou
Making use of the sol-gel technique, an optical pH sensor was prepared, which was made from an organic carrier with four indictors including congo red, bromophenol blue, cresol red, and chlorophenol red, cross-linked by tetraethyl orthosilicate (TEOS) and cellulose acetate. The actual detection range of the optical pH sensor is 2.5–11.0. The optimal ratio of ethyl orthosilicate, absolute ethanol, deionized water, and hydrochloric acid in glue precursor of the sensor-sensitive membrane was explored. The orthogonal experiment was designed to optimize the dosage of cellulose acetate,N,N-dimethylformamide (DMF), indicator, hydrochloric acid, and precursor glue in preparing the sensor-sensitive membrane. The linearity, measurement accuracy, repeatability, stability, and response time of the prepared pH sensor were tested. The measurement results were analyzed using a support vector machine and linear regression. The experimental results show that the optical pH sensor has a measurement accuracy of up to 0.2 pH and better stability and repeatability than the traditional pH glass electrode.Keywords:sol-gel technique;optical pH sensor;indicator;sensor-sensitive membrane
研究领域:
材料科学
·
化学传感器
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ANALYTICA CHIMICA ACTA
·
2018
·
IF 5.123
Yuan Jiao,Xiaojuan Gong,Hui Han,Yifang Gao,Wenjing Lu,Yang Liu,Ming Xian,Shaomin Shuang,Chuan Dong
High-efficient orange fluorescence nitrogen-doped carbon dots (N-CDs) were facilely prepared from P-phenylenediamine as a precursor via hydrothermal method . The as-prepared N-CDs with an average diameter of 3.65 nm displayed excitation-independent emission at 590 nm. The N-CDs demonstrated a remarkable fluorescence enhancement behavior with the increase of pH. A sigmoidal curve was well fitted using BiDoseResp equation with pK a1 3.57 and pK a2 6.01, which can be ascribed to the unique surface properties of N-CDs. Two-segment linear ranges of 2.6–4.6 and 5.0–6.8 broaden the response range to pH of the orange-emission N-CDs to some extent. The confocal fluorescent microscopic images of SMMC7721 cells were performed successfully, which demonstrating that N-CDs possess exceptional cell membrane permeability and can implement as biosensing platform to monitor pH fluctuations in living cells.
研究领域:
生物化学
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材料科学
·
分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MICROCHEMICAL JOURNAL
·
2024
·
IF 4.9
Yujian Bai,Rui Zhu,Jie Zhao,Guofeng Cui
A polyaniline pH sensor with super-Nernstian sensitivity (>59.12 mV/pH) was obtained through acid doping. After preparing polyaniline sensor by potentiostatic electropolymerization, the electrochemical property of sensor can be modulated by adjusting acid doping formulas. The result shows that when using doping solution containing 2.2 g/L sodium dihydrogen phosphate and 5 g/L sodium chloride at pH = 6, the polyaniline sensor exhibits a linear super-Nernstian behavior (−69.31 ± 1.66 mV/pH) in PBS buffer (pH 5.00 ∼ 9.00). We observed that the surface of electrode has a three-dimensional network structure which can greatly increase the surface area of the sensing film, thus improving the conductivity and the sensitivity of the senor. The mechanism of acid doping is revealed: phosphate and polyaniline form salt, which makes polyaniline change from insulator to metal state and improves the conductivity. This is one important reason for its super-Nernstian behavior. In order to better understand this behavior, a new super-Nernstian model is established. The parameter 1/r > 1 is introduced to represent the acid doping index of the sensor, which directly affects the sensitivity of the film. According to the formula, super-Nernstian behavior of pH sensor can be mathematically modeled. This investigation yields a consistently stable super-Nernstian pH sensor while providing enhanced insights into its super-Nernstian characteristics and underlying mechanisms.
研究领域:
材料科学
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电化学
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传感技术
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）