CARBOHYDRATE POLYMERS
·
2018
·
IF 5.158
Ke Li,Sisi Cui,Junli Hu,Yifa Zhou,Yichun Liu
Nanofibers with well-dispersed Ag nanoparticles (AgNPs) are promising for some applications. Dispersion electrospinning is a straightforward preparation method but is suffered from the negative effects that the further treatments of nanofibers after electrospinning may bring to the dispersed AgNPs. In this study, we report a post reduction method to fabricate nanofibers with well-dispersed AgNPs. Crosslinked nanofibers of a hydrophilic polysaccharide, pectin, are used. When being immersed in the aqueous solution of AgNO 3 , the crosslinked pectin nanofibers swell, allowing Ag + ions enter inside. The surrounding crosslinked pectin macromolecules functionalize as in situ reducing reagents to reduce Ag + ions, nucleating the crystallization of AgNPs locally. X-ray diffraction characterizations indicate that the formed AgNPs are face-centered cubic crystalline. Results of optical imaging, UV–vis spectroscopy, scanning electron microscopy (SEM), electron dispersive spectrometry as well as transmission electron microscopy (TEM) indicate that the content and size of AgNPs increase with the increase of AgNO 3 concentration and incubation time. SEM and TEM results show that the dispersion of the AgNPs does not affect the nanofibrous structure and size of the crosslinked pectin nanofibers. TEM results also demonstrate that AgNPs distribute homogeneously along both the length and diameter direction of nanofibers. The composite nanofibers can sustainably release silver for 4 weeks and inhibit the growth of Escherichia coli for 7 days, showing great potential as long-term antibacterial materials. The method may also be used to disperse AgNPs in other hydrophilic nanofibers which need further treatments after electrospinning.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Food & Function
·
2021
·Vol. 12
·期 22
·11656-11670
·
IF 5.396
Simin Feng,Minghui Sui,Dan Wang,Christos Ritzoulis,Mohamed A. Farag,Ping Shao
Due to the insolubility of phytosterols in both water and oil, their application in the medicine and health and food industries is limited. In this study, zein and pectin were selected as wall materials of phytosterol nanoparticles to enhance the solubility and bioactivity of phytosterols. The colitis-inhibitory effects of zein-based stigmasterol nanodispersions (ZNs) and zein/pectin-based stigmasterol nanodispersions (ZPNs) were investigated in the sodium dextran sulfate (DSS)-induced colitis mouse model. The results showed that ZPNs’ therapeutic effect was better than that of ZNs. According to electron microscopy observation, pectin adsorbed on the surface of zein appeared to form an elastic network structure, which increased the stability of stigmasterol nanodispersions. ZPNs not only relieved the adverse physiological symptoms of colitis in mice, but additionally prevented colonic length shortening and reduced fecal hemoglobin content. Immunohistochemical analysis showed that ZPNs could alleviate colitis by inhibiting the NF-κB signaling pathway involved in the expression of inflammatory factors TNF-α, IL-6, IL-1β, CSF-1 and coenzyme COX-2. This study suggests that supplement of nano-embedded stigmasterol based on zein and pectin has a positive therapeutic effect on alleviating colitis in mice. Such activities of nano-embedded stigmasterol in humans remain to be investigated.
研究领域:
食品科学
·
医学
·
生物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CARBOHYDRATE POLYMERS
·
2018
·
IF 5.158
Juan Xu,Hongpo Zhou,Kun Li,Jinju Ma,Wenwen Zhang,Lanxiang Liu,Yanlin Sun,Hong Zhang,Kai Li
The smart polyphenol material could be designed to form two competitive interactions related to same one polyphenol molecule with different objects that could easily adhere to one surface through the weak interaction, and also could be entirely removed from the same surface by the strong interaction. In this study, the multi-scale pectin beads were fabricated by crosslinking with ions that could be acted as polyphenol loading agent through electrostatic force between the ions loading on the surface of pectin beads and polyphenol. The two effects on the size and appearance of pectin beads were detected. Because of the hydrogen bond between polyphenols loading on the beads and the surface of target, fluorescence-functionalized beads could easily adhere on target surfaces. Meanwhile, attributing to stronger electrostatic force between surface ions on beads and polyphenol, the thin membrane made of the beads can be entirely removed from the target surface to avoid the pollution of fluorescence probes.
研究领域:
材料科学
·
生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CERAMICS INTERNATIONAL
·
2025
·
IF 5.6
Shuang Qiu,Xuanwen Xu,Zehua Feng,Lu Li,Xiaoqian Wang,Kai Zheng,Yan Xu
Periodontitis, an inflammatory disease primarily driven by bacterial infection, often leads to the destruction of alveolar bone, presenting a major clinical challenge. To address this, the development of biomaterials that not only inhibit bacterial activity but also stimulate osteogenesis has garnered significant attention. In this study, novel nanocomposite pectin hydrogel microspheres were developed to exhibit both antibacterial and pro-osteogenic properties, as a potential solution for bone tissue regeneration. These microspheres were fabricated by integrating SiO 2 -CaO mesoporous bioactive glass nanoparticles (MBGNs) into pectin hydrogels, followed by cross-linking with either Ca ions or Zn ions. The physicochemical properties, osteogenic potential, and antibacterial efficacy of the resulting microspheres were assessed. The results revealed that the Zn-crosslinked pectin hydrogel microspheres, incorporating MBGNs, exhibited a porous structure with enhanced swelling behavior and slower degradation compared to their Ca-crosslinked counterparts. Notably, these Zn-crosslinked microspheres demonstrated superior antibacterial activity against periodontitis-associated pathogens and significantly promoted osteogenic differentiation of human bone marrow-derived mesenchymal stem cells (hBMSCs). These findings underscore the potential of Zn-crosslinked pectin hydrogel microspheres with MBGNs as a promising therapeutic strategy for enhancing bone tissue regeneration in the context of periodontitis.
研究领域:
牙周病学
·
再生医学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF INORGANIC BIOCHEMISTRY
·
2018
·
IF 3.063
Jiajing Diao,Feng Bai,Ying Wang,Qianqian Han,Xi Xu,Hongmei Zhang,Qiang Luo,Yanqing Wang
In this work, we designed polysaccharide-metal complex of dopamine-modified pectin linking ruthenium compound, which exhibited a certain inhibition specificity to human renal cell adenocarcinoma cell line 786-O. The chemical structure and physical properties of the polysaccharide-metal complex were well characterized by multiple analysis methods. The multi-spectral results revealed that pectin-dopamine have been successfully coordinated by ruthenium complex to form nano-conjugates, which self-assembled into relatively regular nanospheres of approximately 200 nm. The polysaccharide-metal complex has more amorphous and less viscosity than pectin, and cannot withstand as much strain as the pectin and pectin-dopamine systems. Pectin-dopamine can decrease the toxicity effect of Ru complex in normal cell line such as human normal renal epithelial cell line 293A.
研究领域:
生物医学工程
·
药剂学
·
肿瘤学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Bio Materials
·
2025
·
IF 4.7
Lina Song,Wenxian Chen,Xinbo Lu,Ziqiang Liu,Qingqing Rao,Weiqiang Xiao,Xiaoli Zhan,Shengxiang Yang,Feng Gao,Qinghua Zhang
Traditional drug-delivery methods are limited by low bioavailability and nonspecific drug distribution, resulting in poor therapeutic efficacy and potential risks of toxicity. Mesoporous silica nanoparticles (MSNs) have attracted wide attention as drug-delivery carriers due to their large specific surface area, adjustable pore size, good mechanical strength, good biocompatibility, and rich hydroxyl groups on their surface. In this paper, MSNs were synthesized by a template method, and the morphology and pore structure were regulated. The obtained particles possessed a narrow particle size distribution and good sphericity with a diameter of 878 nm, and their growth process was consistent with the La-Mer growth mechanism. Furthermore, MSNs were modified with amino acids and loaded with rosmarinic acid (RosA), accompanied by the “outer packaging” of pectin to obtain RosA@MSNs-Pec. RosA was added at 200, 150, and 100 mg within 72 h, with a drug loading of 193, 175.5, and 156 mg/g and an encapsulation rate of 19.3, 17.6, and 15.6, respectively. Interestingly, RosA@MSNs-Pec demonstrated the dual pH and pectinase response property, and its release curve conformed to the Higuchi model, indicating that its drug-controlled release was based on Fick’s law.
研究领域:
药物递送
·
纳米材料
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Chaoting Wen,Jialuo Tang,Maowei Wu,Huimin Liu,Xinying Lin,Meidi Fan,Guoyan Liu,Jixian Zhang,Li Liang,Xiaofang Liu,Youdong Li,Yuqing Duan,Xin Xu
Quercetin (Que) is a polyhydroxy flavonoid with strong inhibitory activity against cancer cells. However, the poor water solubility and low bioavailability of Que. limit its application in the functional food industry. In the present study, the nanoparticle loaded with Que. was prepared with whey isolate protein (WPI) stabilized by triphenylphosphonium bromide (TPP) and pectin (P) as wall materials. The formation mechanism, release of Que., and antitumor activity of nanoparticles were investigated. The results showed that the optimal ratio of WPI: TPP: Que.: P in the preparation of nanoparticles (WPI-TPP-Que-P) was 50:8:1:20 ( w /w/ w /w). The encapsulation rate of Que. in the WPI-TPP-Que-P was 82.64 % with a particle size of 261.7 nm and a zeta potential of −42.1 mV. Compared with WPI-TPP-Que, the retention rate of WPI-TPP-Que-P increased by 4.03 % after in vitro digestion. The release kinetic result indicated that WPI-TPP-Que-P release was dominated by non-Fickian diffusion. In addition, WPI-TPP-Que-P was taken in and achieved intracellular targeting to mitochondria and promoted apoptosis (apoptosis rate: 83.6 %) by decreasing mitochondrial membrane potential and IL-10 content and improving the content of TNF-α in HepG-2 cells. This study highlights the promising application of P-modified mitochondria-targeted nanocarriers for enhanced Que. delivery.
研究领域:
食品科学
·
生物医学工程
·
药理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2024
·
IF 4.9
Feng Cao,Meiyu Zheng,Wenjuan Zhang,Yangguang Wang,Shengmin Lu
Naringin (NR) has the drawbacks of poor water solubility and low bioavailability, which restricts its applications. The NR-loaded pectin-alginate nanoparticles (PANPs) were prepared by the ion gel method. When the complex polysaccharide concentration, mass ratio of pectin to sodium alginate , molar concentration of CaCl 2 and NR addition were 1 %, 2:1, 0.03 mol/L and 5 mg/mL, respectively, the encapsulation efficiency of PANPs to NR was highest with a value of 79.23 %. Furthermore, multi-factor stability investigation revealed that the NR-loaded PANPs suspension was stable at pH 3–8, NaCl concentration of less than 400 mmol/L, and temperature of less than 75 °C. The NR-loaded PANPs suspension maintained good stability during a storage period of 30 days, and the retention rate of PANPs to NR was as high as 82.51 % at the 30th day, indicating that PANPs had a positive protective role on NR over a longer storage period. The findings might provide a theoretical basis and practical guidance for further exploiting naringin as a functional food ingredient using composite hydrogel encapsulation.
研究领域:
食品科学
·
材料科学
·
药理学
✓ 已验证
产品关联
DOI
高影响因子
Micro & Nano Letters
·
2020
·Vol. 15
·期 9
·595-599
·
IF 0.975
Dezhi Qin,Guangrui Yang,Yabo Wang,Jiajia Zhang,Li Zhang
Pectin-conjugated CdS/ZnS core/shell nanocrystals were prepared by using a microwave-assisted approach without the addition of any external ligands. The prepared cubic phase CdS/ZnS nanocrystals were uniform and mono-dispersed with sizes of 6–9 nm. The charge and long-chain structure of pectin molecules effectively prevented the aggregation of CdS/ZnS nanocrystals. In addition, pectin molecules have multiple functional groups, such as O–H, C=O, and COO − , which could conjugate with the surface of samples to control the growth of CdS/ZnS nanocrystals. Thermogravimetric analysis provided evidence that the obtained products are inorganic–organic hybrid materials. Based on the analysis of ultraviolet–visible spectra, it was found that the formation of ZnS shell led to a red-shift and an enhancement of absorption of CdS/ZnS nanocrystals compared with that of CdS. Photocatalytic activity of CdS/ZnS nanocrystals was monitored by the degradation of Rhodamine B under visible light irradiation. The presence of ZnS shell inhibited photo-corrosion and photo-dissolution of CdS nanocatalyst, thus resulting in a significant enhancement of photocatalytic activity and stability.
研究领域:
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF FOOD SCIENCE
·
2025
·Vol. 90
·期 2
·e70056
·
IF 3.4
Yihan Wang,Kai Wang,Xiaofeng Xiang,Shuming Zhang,Jie Huang,Chunhong Tang,Qiang Wang
The high cholesterol content of beef tallow is one of the potential risks affecting the nutritional value and safety of beef tallow hotpot. In this study, a novel pectin-crosslinked β-cyclodextrin (β-CD) complex was successfully prepared by the cross-linking method to reduce the cholesterol content in beef tallow. When 3% (by mass of beef tallow) of the pectin-crosslinked β-CD
complex was added, the removal rate of cholesterol in beef tallow reached 73.43%, which was significantly higher than that of the currently known materials, including β-CD. Moreover, the indexes such as fatty acid composition, chromaticity, and aroma components of beef tallow before and after cholesterol removal were measured. The results showed that the fatty acid composition and chromaticity value of beef tallow treated with the pectin-crosslinked β-CD complex did not change significantly, but the contents of aromatic components, aldehydes, ketones, and alcohol flavor compounds in beef tallow increased significantly. Through characterization experiments, it was confirmed that compared with β-CD, the pectin-crosslinked β-CD complex required a higher temperature to reach the maximum thermal decomposition rate, indicating that its structure had higher thermal stability and could effectively remove cholesterol under high-temperature conditions. In addition, after the nematode toxicity experiment, there was still a survival rate of 97.97%, indicating that the pectin-crosslinked β-CD complex could effectively reduce the cholesterol content in beef tallow without toxicity. These results suggest that the pectin-crosslinked β-CD complex has great potential as an adsorbent for removing cholesterol from animal fats and oils in the food industry.
研究领域:
食品科学
·
生物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Omega
·
2021
·
IF 3.512
Yinghua Tao,Dan Zheng,Jingyang Zhao,Kefeng Liu,Jing Liu,Jiandu Lei,Luying Wang
Pharmaceutical science based on biological nanotechnology is developing rapidly in parallel with the development of nanomaterials and nanotechnology in general. Pectin is a natural polysaccharide obtainable from a wide range of sources. Here, we show that doxorubicin (DOX)-conjugated hydrophilic pectin (PET) comprising an amphiphilic polymer loaded with hydrophobic dihydroartemisinin (DHA) self-assemble into nanoparticles. Importantly, conjugated DOX and DHA could be released quickly in a weakly acidic environment by cleavage of the acid-sensitive acyl hydrazone bond. Confocal microscopy and flow cytometry confirmed that these PET-DOX/DHA nanoparticles efficiently delivered DOX into the nuclei of MCF-7 cells. Significant tumor growth reduction was monitored in a female C57BL/6 mouse model, showing that the PET-DOX/DHA nanoparticle-mediated drug delivery system inhibited tumor growth and may improve therapy. Thus, we have demonstrated that pectin may be useful in the design of materials for biomedical applications.
研究领域:
药学
·
生物纳米技术
·
肿瘤学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Polymer Materials
·
2025
·
IF 4.7
Md Alim Uddin,Yihua Shen,Li Wang,Haojie Yu,Huanan Wang,Xunchun Yuan,Abdul Basit,Muhammad Owais Malik,Khan Manqoosh Awan,Lichang Xu,Xiwang Yuan,Qiang Li
Because it is noninvasive and radiation-free, magnetic resonance imaging (MRI) is a commonly used imaging method that is very helpful for the early detection and monitoring of malignant growths. The development of alternative imaging probes is essential to reducing the toxicity of contrast agents (CAs) based on metals, such as gadolinium (Gd), which are used in clinical settings. Our goal is to create innovative MRI contrast agents that do not require metallic components and have great stability and relaxivity while still exhibiting excellent efficacy. In this work, the esterification reaction and ring-opening polymerization methods used to successfully synthesize pectin-nitroxide nanoconjugates are demonstrated, and their effective use as a CA for MRI is established. For each radical, the nanoconjugates have a favorable longitudinal water 1H relaxivity of 0.23 and 0.41 mM–1 s–1 for the pectin-TEMPO (PT) and pectin-PGTEMPO (PPGT). The PPGT exhibits notable characteristics like nontoxicity in vivo and resistance to quenching. For longer than 3 h, the PPGT in Wistar female rats shows increased MRI contrast. Comparable contrast enhancement is achieved with PPGT at 3.85 times lower (0.026 mmol/kg) than the standard dose (0.1 mmol/kg). Consequently, the PPGT shows promise as a workable metal-free MRI CA.
研究领域:
医学影像学
·
生物材料学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）