CARBOHYDRATE POLYMERS
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2018
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IF 5.158
Juan Xu,Hongpo Zhou,Kun Li,Jinju Ma,Wenwen Zhang,Lanxiang Liu,Yanlin Sun,Hong Zhang,Kai Li
The smart polyphenol material could be designed to form two competitive interactions related to same one polyphenol molecule with different objects that could easily adhere to one surface through the weak interaction, and also could be entirely removed from the same surface by the strong interaction. In this study, the multi-scale pectin beads were fabricated by crosslinking with ions that could be acted as polyphenol loading agent through electrostatic force between the ions loading on the surface of pectin beads and polyphenol. The two effects on the size and appearance of pectin beads were detected. Because of the hydrogen bond between polyphenols loading on the beads and the surface of target, fluorescence-functionalized beads could easily adhere on target surfaces. Meanwhile, attributing to stronger electrostatic force between surface ions on beads and polyphenol, the thin membrane made of the beads can be entirely removed from the target surface to avoid the pollution of fluorescence probes.
研究领域:
材料科学
·
生物学
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DOI
PubMed
高影响因子
CARBOHYDRATE POLYMERS
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2022
·
IF 10.723
Xinghuan Lin,Hao Zhang,Shanshan Li,Lin Huang,Rongrong Zhang,Lina Zhang,Aixi Yu,Bo Duan
The metal-polyphenol networks have attracted appealing attention for diverse biomedical applications due to their remarkable characteristics. Though various of metal-polyphenolic materials have been prepared, the homogeneous metal-polyphenol based hydrogel fabrication remains a challenge (e.g., quick aggregation). Herein, a facile and low-cost polyphenol-mediating non-covalent driven assembly strategy was developed for fabricating homogeneous chitin-polyphenol-metal hydrogels. Polyphenols not only noncovalently crosslinked chitin chains, but simultaneously captured metal nanomaterials from metal substrates and immobilized in chitin-polyphenol networks. A range of metal (Fe, Cu, Ti, Zn) and polyphenol (tannic acid, gallic acid , quercetin , pyrogallic acid) could be incorporated into this hydrogel framework. As a demonstration, the chitin-tannic acid-Cu hydrogel showed excellent antibacterial properties and significantly enhanced infected wound repair via promoting the cell proliferation and angiogenesis , showing the potential in wound dressing. The low cost, versatility and flexibility assembly process can be used to fabricate diverse polymer-polyphenol-metal hydrogel, thereby enabling their use in various applications.
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DOI
高影响因子
Materials Today Bio
·
2022
·
IF 10.761
Huijia Mao,Yangyang Wen,Yonghui Yu,Hongyan Li,Jing Wang,Baoguo Sun
Chemodynamic therapy (CDT) is a promising tumor-specific treatment, but still suffering insufficient reactive oxygen species (ROS) levels due to its limited efficacy of Fenton/Fenton-like reaction. Polyphenol, as a natural reductant, has been applied to promote the efficacy of Fenton/Fenton-like reactions; however, its intrinsic pro-apoptosis effects was ignored. Herein, a novel CDT/polyphenol-combined strategy was designed, based on Avenanthramide C-loaded dendritic mesoporous silica (DMSN)-Au/Fe 3 O 4 nanoplatforms with folic acid modification for tumor-site targeting. For the first time, we showed that the nanocomplex (DMSNAF-AVC-FA) induced ROS production in the cytoplasm via Au/Fe 3 O 4 -mediated Fenton reactions and externally damaged the mitochondrial membrane; simultaneously, the resultant increased mitochondrial membrane permeability can facilitate the migration of AVC into mitochondrial, targeting the DDX3 pathway and impairing the electron transport chain (ETC) complexes, which significantly boosted the endogenous ROS levels inside the mitochondrial. Under the elevated oxidative stress level via both intra- and extra-mitochondrial ROS production, the maximum mitochondrial membrane permeability was achieved by up-regulation of Bax/Bcl-2, and thereby led to massive release of Cytochrome C and maximum tumor cell apoptosis via Caspase-3 pathway. As a result, the as-designed strategy achieved synergistic cytotoxicity to 4T1 tumor cells with the cell apoptosis rate of 99.12% in vitro and the tumor growth inhibition rate of 63.3% in vivo , while very minor cytotoxicity to normal cells with cell viability of 95.4%. This work evidenced that natural bioactive compounds are powerful for synergistically boosting ROS level, providing new insight for accelerating the clinical conversion progress of CDT with minimal side effects.
研究领域:
癌症治疗
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纳米技术
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药学
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生物化学
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分子生物学
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产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2026
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IF 8.7
Yi Li,Yuehong Liu,Kexian Chen,Shan Huang,Yue Zhang
Mucin-TP binding is dominated by hydrogen bonding and van der Waals forces. • CMC does not appear to alter the mucin-TP interaction mode. • CMC likely weakens mucin-TP interaction binding via competitive and steric effects. • CMC with High MW, low DS show stronger inhibition on mucin-TP at acidic pH. Polysaccharides and polyphenols frequently coexist in food systems and are consumed simultaneously, yet how these interactions influence polyphenol behavior in the gastrointestinal tract remains insufficiently understood. In this study, the effects of carboxymethyl cellulose (CMC) with different concentrations, molecular weights and degrees of substitution on mucin-tea polyphenol (TP) interactions were systematically investigated. Turbidity and zeta-potential measurements indicated that the addition of CMC reduced aggregation of mucin-TP complexes and increased the negative surface charge. Fluorescence spectroscopy further showed that CMC weakened TP-induced quenching of mucin intrinsic fluorescence, suggesting competitive interactions or conformational interference. Thermodynamic analysis suggested that TP-mucin binding was likely driven primarily by hydrogen bonding and van der Waals forces. Although CMC did not alter the apparent interaction mode, it significantly decreased the binding affinity, particularly under acidic conditions simulating the gastric environment. Moreover, the inhibitory effect became stronger with increasing molecular weight and decreasing degree of substitution of CMC. Molecular docking supported these results, revealing that CMC may compete for mucin binding sites or directly interact with TP molecules. These findings provide molecular-level insights into how food polysaccharides modulate mucin-polyphenol interactions and contribute to a better understanding of the factors affecting interaction behaviors of polyphenols and their gastrointestinal bioavailability. This study may offer useful implications for designing polysaccharide-based delivery or modulation systems for dietary polyphenols in food and health-related applications.
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DOI
高影响因子
Food Chemistry-X
·
2024
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IF 6.5
Wenjuan Wu,Cuiping Shi,Ye Zi,Huan Gong,Lijia Chen,Guangyi Kan,Xichang Wang,Jian Zhong
Herein, six types of polyphenol-crosslinked gelatin conjugates (PGCs) with ≥ two gelatin molecules were prepared using a covalent crosslinking method with two types of polyphenols (tannic acid and caffeic acid) and three types of gelatins (bovine bone gelatin, cold water fish skin gelatin, and porcine skin gelatin) for the emulsion stabilization. The structural and functional properties of the PGCs were dependent on both polyphenol and gelatin types. The storage stability of the conjugate-stabilized emulsions was dependent on the polyphenol crosslinking, NaCl addition, and heating pretreatment. In particular, NaCl addition promoted the liquid-gel transition of the emulsions: 0.2 mol/L > 0.1 mol/L > 0.0 mol/L. Moreover, NaCl addition also increased the creaming stability of the emulsions stabilized by PGCs except tannic acid-crosslinked bovine bone gelatin conjugate. All the results provided useful knowledge on the effects of molecular modification and physical processing on the properties of gelatins.
研究领域:
食品科学
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胶体与表面化学
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材料科学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF MEMBRANE SCIENCE
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2021
·
IF 8.742
Xueting Zhao,Ruoxi Wang,Youyou Lan,Tingyuan Wang,Jiefeng Pan,Lifen Liu
Utilizing membrane to deal with the issues of oily wastewater discharge from the processing of petroleum or gas products, oil field exploitation and oil leakage has been widely concerned. Superwetting membrane materials have hold great promising for oil/water separation in recent years. However, a facile strategy to design superwetting membranes with specific micro- and nanostructures is still challenging. In this study, we develop superhydrophilic polycation-polyphenol-metal composite membranes via a facile in situ polyphenol assembly strategy. The assembly of polyphenol (tannic acid, TA)-polycation (polyethyleneimine, PEI) polyelectrolyte complex into nanoconjugates aims to construct a nanostructured coating, and the further complexation of metal ions (M) aims to assemble metal-phenolic networks into TA-PEI nanoconjugates. The resulting dual cross-linked TA-PEI/M composite coatings on polyvinylidene fluoride (PVDF) membrane surfaces show nanopapillae-like structures and excellent superhydrophilicity. The superhydrophilicity of the PVDF/TA-PEI/M membranes greatly promote membrane permeability by more than 100%. The superhydrophilic PVDF/TA-PEI/M membranes are also underwater superhydrophobic . The opposite wettability towards water and oil for the PVDF/TA-PEI/M membranes promises their outstanding oil/water separation efficiency (flux above 3000 L/m 2 h and oil rejection above 99.5%) and anti-oil-fouling performance. Moreover, the representative PVDF/TA-PEI/Ti 4+ membrane also exhibits outstanding chemical and long-term stability thanks to the robust dual cross-linking. This work provides a novel and effective polyphenol-polycation-metal complexation strategy to design and fabricate superwetting membrane for oil/water separation.
研究领域:
材料科学
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环境工程
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DOI
高影响因子
Food Bioscience
·
2023
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IF 5.2
Chen Yang,Jieqiong Liu,Yaqian Han,Bingyi Wang,Ziyun Liu,Haiyue Hu,Zikuan Guan,Yutong Yang,Jianming Wang
Covalent conjugates of pumpkin seed protein isolate (PSPI) and different polyphenols (epigallocatechin gallate (EGCG), chlorogenic acid (CA) and gallic acid (GA)) were prepared at pH 9.0 to develop covalent microparticles to protect the stability of polyphenols under storage and digestive conditions. The results for polyphenol-bound equivalents, free amino group contents, sulfhydryl contents and Sodium Dodecyl Sulfate Polyacrylamide Gel Electrophoresis (SDS-PAGE) indicated that polyphenols were covalently bonded with PSPI, while the secondary structure of conjugates became more regular and stable compared with PSPI alone due to the covalent interactions. EGCG-PSPI conjugates displayed the highest polyphenol-bound equivalents (204.75 nmol/mg) and most stable structure compared with CA-PSPI and GA-PSPI because of the eight active phenolic hydroxyl groups within EGCG, which provided more sites for covalent and non-covalent interactions. Accordingly, EGCG-PSPI microparticles (5–8 μm) were fabricated by cluster aggregation of nano- and micro-sized particles through pH shifting treatment. Compared with the EGCG control, EGCG-PSPI microparticles efficiently increased the retention rate of free radical scavenging activity to 47.47%, 22.04% and 39.94% under light, freeze-thaw cycle storage conditions and simulated intestinal fluids, respectively. Therefore, polyphenol-PSPI covalent conjugate microparticles had great potential to be used as efficient carriers for stabilizing the DPPH radical scavenging ability of polyphenols under illumination storage, freeze-thaw and digestive conditions.
研究领域:
食品科学
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生物化学
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DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
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2021
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IF 13.273
Xiaomeng Zhang,Yang Zong,Longqian Xu,Yunfeng Mao,Deli Wu
Abiotic humification can be facilitated by iron-containing minerals or oxides, but most studies have focused on well-crystallized and stable iron phases, the catalytic effect of which is generally unremarkable. In the present study, we report an enhanced abiotic integrated polyphenol-Maillard humification reaction catalysed by Mg/Fe-layered double hydroxide (Mg/Fe-LDH) with high surface reactivity. The results demonstrated that Mg/Fe-LDH could effectively promote the humification reaction at a lower dosage compared with Fe 2 O 3 . As an iron-chelating ligand, catechol rapidly induced iron dissolution from Mg/Fe-LDH through the formation of an Fe(III)-catechol complex, which strengthened the catalytic effect of Fe(III). The photochemical behaviour of Fe(III)-catechol complex and its impact on the Fe(III)-catalysed humification process were investigated. Under light irradiation, environmentally persistent free radicals (EPFRs) originated from the Fe(III)-catechol complex were formed and stabilized in the presence of Mg/Fe-LDH particles, which inhibited the oxidation of catechol and the humification process. Hence, the formation of humic substances (HS) catalysed by Mg/Fe-LDH was more efficient under darkness. Iron redox cycling and generation of reactive oxygen species (ROS), HO• and O 2 •- , were also involved. According to transformation products (TPs) analysis, ortho -aminophenol was proposed to be a key product in the humification reaction. Self-coupling of catechol radical and ortho -aminophenol radical, ring cleavage were likely to occur in the Fe(III)-catalysed humification process. Higher relative abundance of CHO products was observed in the presence of Mg/Fe-LDH by Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS), suggesting that iron is effective on promoting C–C bonds formation. The above results provide more comprehensive insights into Fe(III)-catalysed humification and a guidance to improve the efficiency of HS formation and carbon sequestration in organic wastes utilization.
研究领域:
环境科学
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有机化学
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产品关联
DOI
高影响因子
ACS Applied Electronic Materials
·
2024
·
IF 4.3
Lei Xu,Hui Sun,Jiazhuang Chen,Youxiu Xie,Xinyu Liu,Bin Yu
This paper presents an approach to enhancing nanocellulose aerogels as flexible piezoresistive sensor substrates by constructing polyphenol–metal networks within the aerogel structure. Specifically, tannic acid (TA), a plant-based polyphenol, is utilized to improve the aerogel’s mechanical properties, such as compressive strength and elasticity, which are essential for durability in sensor applications. The integration of multiwalled carbon nanotubes (MWCNTs) with nanocellulose further bolsters the aerogel’s electrical conductivity, with TA playing a key role in stabilizing the dispersion of MWCNTs within the nanocellulose matrix. The resulting aerogel, prepared through freeze-drying, exhibits significant improvements: a compressive strength of 316.7 kPa under 50% deformation, which is 3 times that of a pure nanocellulose aerogel, an impressive 80% elastic recovery rate, and a consistent performance under cyclic compression for 3600 s. This work offers a sustainable and straightforward approach to creating flexible sensor substrates with enhanced mechanical resilience and stable electrical properties, aligned with green material sourcing and scalability.
研究领域:
材料科学
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绿色化学
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传感技术
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产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
·
IF 8.7
Caiyun Zheng,Fangfang Hu,Qian Gao,Zhaoxu Ji,Jinxi Liu,Jianing Li,Ziyi Yang,Yanni Zhang,Xianglong Wu,Tingli Lu
A DNA-polyphenol wet-adhesive hydrogel is developed for rapid hemostasis. • The hydrogel exhibits robust wet adhesion and favorable coagulation-related performance. • Effective hemostasis is achieved in multiple bleeding models, including high-pressure arterial injury. Rapid hemostasis under wet and dynamic conditions remains a major challenge for wound management. Herein, a DNA-polyphenol wet-adhesive hydrogel was developed by integrating DNA with tannic acid (TA), dopamine (DOPA), and mesoporous bioactive glass (MBG). The resulting hydrogel exhibited robust wet adhesion, enabling effective sealing on various substrates and biological tissues. The integration of DNA, polyphenol components, and MBG endowed the hydrogel with enhanced adhesive properties, with an adhesive strength exceeding 35 kPa after prolonged immersion. In vitro studies demonstrated enhanced coagulation-related performance, including a reduced blood clotting index and shortened clotting time, together with high fluid absorption capacity. In vivo studies in rat liver injury, rat tail amputation, and rabbit femoral artery models further demonstrated effective hemostatic performance, with reduced blood loss and shortened hemostasis time, even under high-pressure bleeding conditions. In addition, the hydrogel exhibited good cytocompatibility, distinct in vitro release behavior, and progressive in vivo resorption with favorable tissue compatibility. These results suggest that the DNA-polyphenol hydrogel is a promising biomacromolecule-based material for rapid hemostasis and wound sealing applications.
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DOI
高影响因子
BIOMATERIALS
·
2026
·
IF 12.9
Ning Cong,Lu Guo,Xiaoxuan Wang,Yading Zhao,Ting Zhao,Shuting Huang,Rui Liu,Song Ning,Xiaoying Zhou,Suyun Li,Yuye Fu,Jie Li
Cuproptosis is a novel form of cell death that relies on mitochondrial metabolism and has opened up new avenues for tumor therapy. However, resistance to cuproptosis in tumors can arise from several factors, such as their reliance on aerobic glycolysis, the high-glutathione (GSH) environment, and inefficient copper (Cu) delivery. In this study, we developed shell-core nanodroplets (NDs) approximately 280 nm in diameter, named Cu-EGCG-SHK-NDs. These NDs are composed of a liquid-gas phase-change perfluorohexane core and a carboxymethyl chitosan shell, loaded with the glycolytic inhibitor shikonin (SHK) and coated with Cu-complexed epigallocatechin gallate (Cu-EGCG), enabling targeted delivery through ultrasound (US)-targeted microbubble destruction (UTMD). The dual responsiveness of NDs to both US and pH enables precise drug release and efficient intracellular uptake. In addition, the US response enhances contrast-enhanced US imaging and triggers the generation of reactive oxygen species, subsequently depleting GSH. Both in vitr o and in vivo experiments confirm that Cu-EGCG-SHK-NDs possess excellent biocompatibility. Combined with UTMD, they can efficiently co-deliver Cu and SHK into tumour cells, inhibit glycolytic metabolism, and significantly reduce intracellular GSH levels. This synergistic mechanism enhances cuproptosis induction and achieves effective tumour growth inhibition.
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产品关联
DOI
PubMed
高影响因子
Nature Communications
·
2023
·Vol. 14
·期 1
·1-9
·
IF 16.6
Zhu Bin,He Shanshan,Yang Yan,Li Songwei,Lau Cher Hon,Liu Shaomin,Shao Lu
Advances in membrane technologies are significant for mitigating global climate change because of their low cost and easy operation. Although mixed-matrix membranes (MMMs) obtained via the combination of metal-organic frameworks (MOFs) and a polymer matrix are promising for energy-efficient gas separation, the achievement of a desirable match between polymers and MOFs for the development of advanced MMMs is challenging, especially when emerging highly permeable materials such as polymers of intrinsic microporosity (PIMs) are deployed. Here, we report a molecular soldering strategy featuring multifunctional polyphenols in tailored polymer chains, well-designed hollow MOF structures, and defect-free interfaces. The exceptional adhesion nature of polyphenols results in dense packing and visible stiffness of PIM-1 chains with strengthened selectivity. The architecture of the hollow MOFs leads to free mass transfer and substantially improves permeability. These structural advantages act synergistically to break the permeability-selectivity trade-off limit in MMMs and surpass the conventional upper bound. This polyphenol molecular soldering method has been validated for various polymers, providing a universal pathway to prepare advanced MMMs with desirable performance for diverse applications beyond carbon capture.
研究领域:
材料科学
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环境工程
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化学工程
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DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）