Preparation and growth orientation modulation of Mn0.6Zn0.4Fe2O4 nanoparticles as MRI contrast agents
Ferrite nanoparticles are widely used in magnetic resonance imaging as T 2 contrast agent particles. In this study, we propose to utilize Mn and Zn doping into ferrite to prepare Mn-Zn doped ferrite and use it as T 2 contrast agent core particles. Also, we aim to clarify the relationship between the Mn-Zn doped ferrite nanoparticles orientation and ratio of surfactant oleic acid to oleylamine as well as different solvents. The results show that high temperature thermal decomposition method can successfully prepare uniformly doped Mn-Zn ferrite nanoparticles (Mn 0.6 Zn 0.4 Fe 2 O 4 ). And the ratio of surfactant oleic acid to oleylamine has a significant impact on the orientation of Mn 0.6 Zn 0.4 Fe 2 O 4 nanoparticles growth. As the ratio of oleic acid increases, the Mn 0.6 Zn 0.4 Fe 2 O 4 nanoparticles gradually change from growing along the [110] crystal direction to growing randomly with irregular orientation, the nanoparticles morphology and size tend from rhombohedral (37 nm) to spherical (9.84 nm). In terms of solvent, benzyl ether, 1-octadecene and hexadecylamine have no influence on the action of surfactants. The Mn 0.6 Zn 0.4 Fe 2 O 4 nanoparticles in the three solvents are grown randomly without any obvious orientation changes. All nanoparticles are spherical nanoparticles, indicating that the choice of the three solvents has little effect on the orientation of the nanoparticles. However, the three different solvents affect the crystallinity of Mn 0.6 Zn 0.4 Fe 2 O 4 nanoparticles. Nanoparticles prepared with diphenyl ether as solvent show a higher crystallinity compared to those synthesized with 1-octadecene and hexadecylamine as solvents. In contrast performance, under the optimal surfactant ratio (11:1) and solvent selection (dibenzyl ether), the transverse relaxation rate r 2 value of Mn-Zn ferrite nanoparticles reach 266.24 mM −1 s −1 , while the longitudinal relaxation rate r 1 value is 10.45 mM −1 s −1 . The r 2 / r 1 ratio is significantly larger than 10, indicating that the nanoparticles with random growth orientation serve as excellent T 2 weighted contrast agents.
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