CARBOHYDRATE POLYMERS
·
2019
·
IF 6.044
Xiaoliang Qi,Zhipeng Li,Liangliang Shen,Tao Qin,Yuna Qian,Shengzhe Zhao,Minchao Liu,Qiankun Zeng,Jianliang Shen
Wastewater treatment materials that combine high decontamination performance, ease of use and economic production are highly desirable for practical applications. Herein, we fabricated a low-cost and recyclable bio-adsorbent based on a microbial polysaccharide (salecan) for efficient removal of methyl violet (MV) from wastewater. The success fabrication and the properties (such as thermal stability, microarchitecture, mechanical strength and water uptake) of the adsorbent had been investigated, and the hydrogels were found to have tunable properties by simple adjusting the salecan dose in hydrogel composition. Adsorption data displayed that the adsorption of MV followed the pseudo second-order kinetic model (R 2 = 0.99015) and Freundlich isotherm model (R 2 = 0.99221) with a maximum adsorption capacity of 178.9 mg/g. Moreover, salecan-based hydrogels showed a good reversibility in adsorption–desorption cycles. These features indicate that salecan-based bio-adsorbent may be a promising device for dye removal from dyeing waste water.
研究领域:
环境科学
·
生物材料学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CARBOHYDRATE POLYMERS
·
2018
·
IF 5.158
Xinyu Hu,Yongmei Wang,Liangliang Zhang,Man Xu,Jianfa Zhang,Wei Dong
Salecan, a water-soluble extracellular β-glucan, has emerged as a promising candidate for preparing hydrogel biomaterials recently. Herein, photo cross linked composite hydrogels, composed by salecan/poly ( N-tert -butylacrylamide-co-acrylamide) network andα-Mo 2 C nanoparticles were prepared by ultraviolet (UV) light, using Irgacue 2959 as photo initiator. The XRD and EDX analysis illustrated the presence of embeddedα-Mo 2 C nanoparticles throughout the hydrogel matrix. Compression tests and thermal analysis revealed that the incorporation of α-Mo 2 C nanoparticles enhanced mechanical strength and thermal stability due to the structural reinforcement of the composite hydrogels. Moreover, the change of salecan content provided a mean to tailor both the swelling property and morphology of the composite hydrogels. Encapsulation of L929 and 3T3-L1 cells and the following viability test showed the excellent cell-compatibility of these hydrogels. Taken together, these studies support the use of photo crosslinked composite hydrogels as tunable biomaterials for cell adhesion.
研究领域:
生物材料学
·
组织工程
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Food & Function
·
2022
·Vol. 13
·期 22
·11744-11757
·
IF 6.317
Panpan Li,Yanjun Liu,Juan Zhao,Wenjie Pan,Yuan He,Shunzhe Fu,Yuanfa Liu,Yong-Jiang Xu
Salecan, a natural β-glucan consisting of seven residues linked by β-(1→3)/α-(1→3) glycosidic bonds, is one of the novel food ingredients approved in China. β-Glucan has a variety of health-improving effects, yet its mechanism against liver injury remains poorly understood. β-Glucan can induce shifts in the gut microbiota and show health benefits; however, whether modulation of the gut microbiota by β-glucan is associated with its benefits remains unclear. Here, the hepatoprotective effect and potential mechanism of salecan supplementation using a model of CCl4-induced liver injury were investigated. After 8 weeks of treatment, salecan alleviated liver injury by regulating oxidative stress and activating the Nrf2 signaling pathway. In addition, salecan treatment modulated the composition of the gut microbiota, and the antibiotic cocktail treatment indicated that the hepatoprotective effect of salecan was dependent on the gut microbiota. Fecal microbiota transplantation was used to further verify this mechanism, and we confirmed that microbial colonization partially alleviated liver injury. Besides, microbiota-derived metabolites of salecan also contributed to the hepatoprotective effect of salecan against liver injury and inhibited oxidative stress. These findings supported that salecan intervention attenuated liver injury by regulating the gut microbiota and its metabolites.
研究领域:
营养学
·
肝病学
·
微生物学
·
药理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Xinyu Hu,Linlin Yan,Man Xu,Lihua Tang
As dye adsorbents with great potential, polysaccharide-based hydrogels are significantly hampered in practical application owing to intricate preparation methods, low absorption, and bad degradability. Salecan is a water-soluble extracellular polysaccharide with excellent physicochemical and biological properties. Here, salecan and xanthan gum were first used as a dual-precursors system, their mixed solution was crosslinked by Fe 3+ to assemble a photo-degradable ionic gel for malachite green (MG) adsorption. Photo-degradation was done using visible light under very mild conditions, which gave rise to gel network dissolution and homogeneous solution formation. Extensive dynamic coordinate interactions between Fe 3+ and polysaccharides maintained gel matrix stability and were systematically investigated. The control of water uptake, micro-structure, and rheology can be facilely implemented by tuning salecan/xanthan gum ratios. Furthermore, various parameters such as polysaccharide ratios, pHs, MG concentrations, and contact time affecting adsorption were optimized using batch experiments. Adsorption process accurately adhered to pseudo-second-order kinetic and Langmuir isotherm model, with the maximum adsorption capacity of 463.0 mg/g. Such mechanism implied monolayer chemisorptive characteristics. The gel exhibited satisfactory reusability and was recycled five times without apparent decrease in adsorption capacity. From these results, the photo-degradable Fe 3+ -induced salecan/xanthan gum ionic gel is an alternative and sustainable absorbent for MG removal.
研究领域:
材料科学
·
环境科学
·
生物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
·
2017
·
IF 4.164
Xiaoliang Qi,Wei Wei,Junjian Li,Ting Su,Xihao Pan,Gancheng Zuo,Jianfa Zhang,Wei Dong
Salecan is a new linear extracellular β-glucan. The unique structure and beneficial properties of Salecan makes it an appealing material in biomedical applications. In this work, novel drug devices based on Salecan in a hydrogel matrix of poly( N -(3-dimethylaminopropyl)acrylamide- co -acrylamide) (Salecan/PDA) were fabricated via free radical polymerization for controlled release of amoxicillin. It was demonstrated that amoxicillin was efficiently encapsulated into the developed hydrogels and released in a Salecan dose-dependent and pH-sensitive manner. Furthermore, cell toxicity and adhesion assays confirmed that these drug carriers were biocompatible. Altogether, this study opens a new avenue to fabricate hydrogel devices for controlled delivery of drug.
研究领域:
药学
·
生物医学工程
·
药物递送系统
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2017
·
IF 3.671
Wei Wei,Xiaoliang Qi,Junjian Li,Yin Zhong,Gancheng Zuo,Xihao Pan,Ting Su,Jianfa Zhang,Wei Dong
Salecan is a biological macromolecular and biocompatible polysaccharide that has been investigated for recent years. Herein, we report a novel cationic hydrogel fabricated by graft-polymerizing 3-(methacryloylamino)propyl-trimethylammonium chloride (MAPTAC) onto salecan chains. The obtained hydrogels were transparent, solid-elastic, macro-porous, ion-sensitive, and non-cytotoxic. The swelling ratios increased with salecan content, while mechanical strength does the opposite. Moreover, drug delivery test was studied as a potential application. Diclofenac sodium (DS) and insulin were selected as model drugs. Interestingly, in drug loading process, DS molecules exhibited highly affinity to these cationic hydrogels. Almost all the DS molecules in loading solution were absorbed and spread into the hydrogel. For drug release profiles, insulin-loaded hydrogel showed an initial rapid release and a sustained release. As a comparison, DS-loaded hydrogel exhibited a more sustained release profile. Results suggested salecan-g-PMAPTAC hydrogel could be a good candidate for anionic drug loading and delivery.
研究领域:
材料科学
·
生物医学工程
·
药剂学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ChemMedChem
·
2017
·Vol. 12
·期 19
·1600-1609
·
IF 3.225
Xinyu Hu,Yongmei Wang,Liangliang Zhang,Man Xu,Jianfa Zhang,Wei Dong
Graphical The power of attraction : Salecan-based composite hydrogels have magnetic-field-responsive properties due to the introduction of Fe 3 O 4 @SiO 2 nanoparticles into the hydrogel system. As a model anticancer drug, doxorubicin (DOX) was loaded into the composite hydrogels with high efficiency via strong electrostatic interactions between the amine group in DOX and carboxyl groups present in the hydrogels. These DOX-loaded salecan-g-PPH/Fe 3 O 4 @SiO 2 composite hydrogels show pH-responsive controlled drug release, and the liberated DOX can be effectively taken up by A549 cells. Salecan is a water-soluble extracellular β-glucan and has excellent physicochemical and biological properties for hydrogel preparation. In this study, a new pH/magnetic field dual-responsive hydrogel was prepared by the graft copolymerization of salecan with 4-pentenoic acid (PA) and N -hydroxyethylacrylamide (HEAA) in the presence of Fe 3 O 4 @SiO 2 nanoparticles for doxorubicin hydrochloride (DOX) release. Integration of Fe 3 O 4 @SiO 2 nanoparticles in salecan-g-poly(PA-co-HEAA) copolymers afforded magnetic sensitivity to the original material. DOX-loaded hydrogels exhibited a clear capacity for pH/magnetic field dual-responsive controlled drug release. Lowering the pH to acidic conditions or introducing an external magnetic field caused an enhancement in DOX release. This salecan-g-poly(PA-co-HEAA)/Fe 3 O 4 @SiO 2 composite hydrogel is a promising drug carrier for magnetically targeted drug delivery with enhanced DOX cytotoxicity against A549 cells.
研究领域:
材料科学
·
药学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2016
·Vol. 6
·期 74
·69869-69881
·
IF 3.289
Xiaoliang Qi,Wei Wei,Junjian Li,Gancheng Zuo,Xinyu Hu,Jianfa Zhang,Wei Dong
Salecan is a novel water-soluble extracellular polysaccharide composed of a linear repeating unit of 1-3-linked glucopyranosyl. Salecan is suitable for the preparation of hydrogels for biomedical applications due to its outstanding biological and physicochemical profiles. Here we designed a novel semi-interpenetrating polymer network (semi-IPN) hydrogel that incorporated the hydrophilic polysaccharide Salecan into a stimuli-responsive poly(N-isopropylacrylamide-co-methacrylic acid) (PNM) hydrogel matrix for controlled drug release. In this research, on one hand, Salecan modified the architecture and the pore size of the semi-IPN network. On the other hand, Salecan played a vital role in modulating water content and tuning the water release rate of the developing hydrogel, resulting in an adjustable release rate of the drugs. Doxorubicin (DOX), an anticancer drug, was loaded into the semi-IPN hydrogels as a model drug, and the in vitro release assay exhibited that the release rate was closely related to the content of introduced Salecan, as well as the environmental temperature and pH of the release media. Cytotoxicity experiments demonstrated that all blank semi-IPN hydrogels were non-toxic to HepG2 and A549 cells, while drug released from the DOX-loaded hydrogels could still exert its pharmacological activity and had the ability to kill these two cancer cells. Altogether, this work provides a way to synthesize a new type of hydrogel as general drug delivery vectors with a desired release rate.
研究领域:
生物材料
·
药物递送系统
·
高分子化学
✓ 已验证
产品关联
DOI
高影响因子
POLYMER TESTING
·
2018
·
IF 2.247
Xinyu Hu,Yongmei Wang,Liangliang Zhang,Man Xu,Jianfa Zhang,Wei Dong
Salecan, a water-soluble extracellular β-glucan, is suitable for preparing hydrogels owing to its good physicochemical and biological properties. Semi-interpenetrating network (semi-IPN) technology and ultraviolet (UV) light crosslinking mechanisms were combined to create composite hydrogels based on salecan/poly (2-(diethylamino)ethyl methacrylate-co- N -hydroxyethyl acrylamide) network and niobium carbide (NbC) nanoparticles . FT-IR characterization confirmed the formation of the semi-IPN structure. XRD diffraction peaks corresponding to NbC was clearly observed in the patterns of the photocrosslinked composite hydrogels. In particular, the results obtained from compression tests and thermal analysis demonstrated that introduction of NbC nanoparticles into the network matrix enhanced mechanical strength and thermal stability due to the structural reinforcement of the composite hydrogels. In addition, the morphology and swelling of the hydrogels could be well tuned by controlling salecan content. Cytotoxicity test followed by Live/Dead cell viability assay demonstrated that these composite hydrogels had excellent cytocompatibility, showing their potential as cell adhesion materials.
研究领域:
材料科学
·
生物材料
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
CARBOHYDRATE POLYMERS
·
2016
·
IF 4.219
Xinyu Hu,Yongmei Wang,Liangliang Zhang,Man Xu,Wei Dong,Jianfa Zhang
Salecan is a novel water-soluble extracellular β-glucan and possesses excellent physicochemical and biological properties. Here, redox/pH dual stimuli-responsive hydrogel based on Salecan grafted with itaconic acid (IA) and 2-hydroxyethyl methacrylate (HEMA) were prepared using disulfide-functionalized crosslinker N,N - bis (acryloyl)cystamine (BAC) for controlled drug delivery. The introduction of carboxylic groups endows the system with pH-sensitive character, swelling behavior of the hydrogel was conducted by changing the pH and Salecan content. It was demonstrated that DOX was efficiently loaded into the hydrogels and released in a controlled fashion via pH-control and swelling-shrinking mechanism. More importantly, DOX-loaded hydrogels showed dose dependent cytotoxicity toward A549 cell, and efficient cell killing was observed. Furthermore, a key point of this study was that the presence of disulfide linkage in system favored the degradation of hydrogels in the reductive environment. These results highlight the potential of Salecan- g -SS-poly(IA- co -HEMA) hydrogel as a novel system for the controlled release of anti-cancer drugs.
研究领域:
药学
·
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2018
·
IF 3.909
Xinyu Hu,Yongmei Wang,Man Xu,Liangliang Zhang,Jianfa Zhang,Wei Dong
Salecan is a water-soluble extracellular β‑glucan and appropriate for preparing hydrogels applicable in biomedical field. Herein, an innovative photocrosslinked composite hydrogel composed of salecan/poly(hydroxypropyl methacrylate (PHPMA) network and titanium carbide (TiC) nanoparticles was successfully prepared. XRD patterns clearly showed the crystal planes of Ti. More importantly, the introduction of TiC nanoparticles into the hydrogel network provided structural reinforcement, and thereby synergistically enhanced the mechanical strength and thermal stability of the hydrogels. The change of salecan content markedly affected the swelling behavior and morphology of the composite hydrogels. Cytotoxicity results revealed that the composite hydrogels were non-toxic to L929 and 3T3L1 cells. Cell proliferation and Live/Dead assay further demonstrated excellent cytocompatibility of the cells within the composite hydrogels, which highlights the value of this system for potential application as soft tissue engineering scaffold.
研究领域:
生物医学工程
·
材料科学
·
细胞生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2025
·
IF 9.8
Jiao Lin,Juan Dai,Qian Yang,Jiarui Li,Jing Xiao,Yuexin Zhang,YuKun Huang,Lijun Wang,Pengfei Chen,Buyi Xu,Juan Zhao,Xiao Yang,Xianggui Chen
Chilled meat is highly prone to microbial spoilage, and edible films with antimicrobial properties offer a feasible solution. In this study, oil-in-water (O/W) nanoemulsions loaded with lemon essential oil (LEO) were developed. Nanoemulsification improved the antioxidant and antimicrobial activities of LEO. The edible films, using Salecan β-glucan as the matrix and incorporating varying ratios of LEO nanoemulsion, demonstrated uniform oil distribution and desirable appearance. Kinetic modeling showed a slow release of LEO from the film by a diffusion-dominated coupled mechanism. The film with 5 % LEO nanoemulsion displayed superior mechanical strength, barrier properties, and prolonged essential oil release, significantly inhibiting spoilage bacteria. Preservation tests confirmed its efficacy in controlling pH, total viable count, TVB-N, and lipid oxidation, thereby prolonging the shelf-life of chilled pork and significantly delaying deterioration in quality indicators such as color and texture. This approach presents a promising method for developing innovative edible films for chilled meat preservation.
研究领域:
食品科学
·
生物技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）