JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2025
·
IF 6.2
Huabin Liao,Feina Gu,Ya Wen,Weichun Pan,Fuge Niu
Oral administration of polysaccharide-iron complexes (UCP-Fe(III)) is limited by their degradation in the gastric environment, which reduces bioavailability. We developed core–shell sodium alginate/chitosan hydrogel microsphere for pH-responsive UCP-Fe(III) delivery. High sodium alginate (SA) concentrations increased viscosity and storage modulus, enhancing mechanical stability. The encapsulation efficiency of UCP-Fe(III) reached 94.41% using 2.0% SA. Noncovalent interactions between UCP-Fe(III) and SA contributed to enhanced hardness and chewiness of the microspheres, while higher SA concentrations promoted a denser cross-linked network. The hydrogel microspheres showed low swelling in simulated gastric fluid (SGF, pH 2.0; swelling ratio: 467.33–588.50%) but rapid swelling in simulated intestinal fluid (SIF, pH 7.4; swelling ratio: 800–962.17%), indicating significant pH responsiveness. They effectively prevented premature release (only 12.14–23.48% in SGF after 2 h) while enabling sustained release (87.60–95.16% in SIF after 6 h). This study provides a new strategy for developing oral iron supplements with pH-responsive sustained-release properties.
研究领域:
药剂学
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生物材料
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药物递送系统
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胃肠病学
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营养学
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高分子科学
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产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry B
·
2025
·
IF 5.7
Xue Wu,Lianyi Yang,Qing Chen,Ruijin Ran,Jun Cao,Ming Zhang
Experimental autoimmune uveitis (EAU) is a widely used model for noninfectious uveitis (NIU), a sight-threatening autoimmune ocular disease. Although glucocorticoids remain the first-line therapy, their short half-life and frequent administration increase the risk of systemic and ocular side effects. Here, we report the development of microenvironment-responsive hydrogels with drug-loaded microspheres for sustained dexamethasone acetate release: dexamethasone acetateloaded microspheres (DAMS) and polyethylene glycol (PEG) hydrogel-encapsulated microspheres (DAMS@Gel). Poly(lactic-co-glycolic acid) (PLGA) microspheres were fabricated and subsequently embedded in pH-responsive and injectable hydrogel formed via Schiff base crosslinking. The materials were then thoroughly characterized.In vitro, both DAMS and DAMS@Gel showed excellent biocompatibility with retinal pigment epithelial (ARPE-19) cells, as confirmed by reactive oxygen species (ROS), apoptosis, cell cycle, and cytotoxicity assays. In vivo safety was verified through subconjunctival injection in rabbits. In the rat EAU model, intravitreal administration of DAMS and DAMS@Gel significantly alleviated ocular inflammation, as evidenced by ocular inflammatory symptom observations, fundus imaging, histopathological examination, and decreased glial activation. This study demonstrated that the DAMS and DAMS@Gel drug delivery systems were successfully established and exhibited sustained release properties and stable characteristics. In vitro and in vivo assays indicated that the biological materials had excellent biocompatibility. In addition, both of DAMS and DAMS@Gel exerted therapeutic effects on EAU model rats, and intraocular inflammation was markedly reduced. This research may provide a theoretical foundation for the treatment of uveitis with DAMS and DAMS@Gel.
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DOI
PubMed
高影响因子
JOURNAL OF CONTROLLED RELEASE
·
2022
·
IF 11.467
Qian Chen,Yanan Li,Shuai Zhou,Dali Chen,Muye Zhou,Qinying Chen,Yuren Lu,Naicong Cai,Can Liu,Yumeng Guo,Zijie Qiu,Xiaoyan Hou,Jiasheng Tu,Weiyang Shen,Chunmeng Sun
Postsurgical treatment is of great importance to combat tumor recurrence and metastasis. Anti-CD47 antibodies (aCD47) can block the CD47-signal regulatory protein-alpha (CD47-SIRPα) pathway to restore immunity. Here, an in-situ gel implantation was engineered by crosslinking chitosan (CS) and pullulan (Pul) for postsurgical treatment. A highly selected chemotherapeutic, cyclopamine (Cyc), encapsulated in liposomes (Cyc-Lip) was co-loaded with aCD47 in gels for chemoimmunotherapy. Importantly, a sequential drug release kinetics can be achieved. Nanotherapeutics were confirmed to be released prior to aCD47 in a burst-release manner, which was benefit for immediately killing residual tumor cells followed by releasing tumor antigens . Meanwhile, aCD47 was released in a sustained-release manner to restore macrophage functions and exert anti-tumor immune responses. Afterwards, the efficacy of in-situ chemoimmunotherapy was confirmed on 4T1 mouse breast cancer models, which could not only efficiently augment anti-tumor effect to inhibit tumor recurrence but also establish a long-term immune memory to combat tumor metastasis.
研究领域:
肿瘤学
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生物材料学
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免疫学
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DOI
PubMed
高影响因子
CELLULOSE
·
2023
·Vol. 30
·期 5
·3073-3082
·
IF 5.7
Wang Yanan,Zhao Hanyu,Huang Lijie,Chen Guangxue,Wei Zhehao,Mo Qi,Li Yishan,Wang Xiyue,Huang Chongxing,Chen Qifeng
Owing to unique physiochemical and biological properties as well as the ability to be combined with a wide variety of materials for both biocompatibility and hydrophilia, carboxymethyl cellulose (CMC) is an excellent choice as a carrier. Loading Chlorine dioxide (ClO 2 ) into biodegradable carrier for its good disinfection performance and high safety factors has attracted significantattention. Therefore, in this study, we used ClO 2 as a model drug, and a sustained-ClO 2 -gas-release gel was developed from degradable materials, such as carboxymethyl cellulose (CMC), polyvinyl alcohol (PVA), and β-cyclodextrin (βCD), through a simple and benign crosslinking strategy. Notably, the gel had sustained-release property in a wide temperature range of 4–35 ℃ and released ClO 2 gas effectively for more than 30 days. Furthermore, a loss factor was proposed based on the incomplete release of the drug in the sustained release process to a chieve a good fit with the gas diffusion process. A new diffusion model was designed based on the Korsmeyer–Peppas model, and an excellent fit was obtained. This sustained-ClO 2 -gas-release gel provides theoretical and technical guidance for the development of sustained-disinfectant-release agents for use in space and offers new insights into the sustained release model of skeleton-soluble hydrogels. Graphical abstract
研究领域:
材料科学
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生物医学工程
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环境科学
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产品关联
DOI
PubMed
高影响因子
COLLOID AND POLYMER SCIENCE
·
2020
·Vol. 298
·期 9
·1187-1195
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IF 1.536
Xu Pingping,Tan Yun,Wang Xionglei,Xu Huaxiu,Wang Di,Yang Yang,An Wenli,Xu Shimei
We prepared two types of multidimensional gradient hydrogels by simple electrophoresis using spherical graphite electrode. To explore their application in controlled drug release, rhodamine B (RB) and sodium salicylate (SS) were used as oppositely charged drug models respectively to in situ loading into the hydrogels by electrostatic interaction with the charged components accordingly. In both cases, the model drugs and the charged components of the hydrogels were gradiently distributed with the drug concentration increased from the gel surface to the gel core. For the crosslinking gradient hydrogel prepared at 2 V, the network size near the gel surface is about 3 times that of the gel core, and the release rate is 0.85 times of that of the non-gradient hydrogel. For the polymer chain gradient hydrogel prepared at 2.5 V, the relative content of polymer chain near the core of the gel is 2.5 times that of the gel surface, and the release rate is 0.71 times of the non-gradient hydrogel.
研究领域:
材料科学
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药剂学
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产品关联
DOI
高影响因子
ACS Applied Polymer Materials
·
2022
·
IF 4.855
Fangwei Qi,Zhihui Wang,Yang Shuai,Shuping Peng,Cijun Shuai
Strontium ion (Sr2+) enabled us to endow polymer bone scaffolds with bioactivity owing to its excellent osteoinductive capacity. Nevertheless, the burst release of Sr2+ hindered its further application. Herein, strontium substituted hydroxyapatite (SrHA) was constructed to achieve a sustained release system. Specifically, Sr2+ could substitute Ca2+ in a HA lattice framework through ion exchange due to their similar ion radius. The ionic bond formed by Sr2+ and surrounding ions could prevent the rapid escape of Sr2+ and thereby achieve the sustained release of Sr2+. Subsequently, SrHA was introduced into the poly-l-lactic (PLLA) scaffold fabricated by selective laser sintering. Results demonstrated that PLLA/SrHA scaffolds presented a sustained Sr2+ release with a cumulative concentration of 5.6 mg/L over 28 days. The released Sr2+ significantly promoted the cell proliferation and differentiation. Furthermore, the tensile and compressive strengths of PLLA/SrHA scaffolds were also greatly enhanced in comparison with that of PLLA scaffolds. These positive findings demonstrated that PLLA/SrHA scaffolds had considerable potential for bone repair.
研究领域:
生物材料学
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骨组织工程
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医学
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产品关联
DOI
高影响因子
Advanced Science
·
2024
·
IF 14.3
Junjie Mao,Zhenqian Sun,Shidong Wang,Jianqiang Bi,Lu Xue,Lu Wang,Hongliang Wang,Guangjun Jiao,Yunzhen Chen
In this study, a novel bionic periosteum (BP)-bioactive glass fiber membrane (BGFM) is designed. The introduction of magnesium ion (Mg 2+ ) and zinc ion (Zn 2+ ) change the phase separation during the electrospinning (ES) jet stretching process. The fiber's pore structure transitions from connected to closed pores, resulting in a decrease in the rapid release of metal ions while also improving degradation via reducing filling quality. Additionally, the introduction of magnesium (Mg) and zinc (Zn) lead to the formation of negative charged tetrahedral units (MgO 4 2− and ZnO 4 2− ) in the glass network. These units effectively trap positive charged metal ions, further inhibiting ion release. In vitro experiments reveal that the deigned bionic periosteum regulates the polarization of macrophages toward M2 type, thereby establishing a conducive immune environment for osteogenic differentiation. Bioinformatics analysis indicate that BP enhanced bone repair via the JAK-STAT signaling pathway. The slow release of metal ions from the bionic periosteum can directly enhance osteogenic differentiation and vascularization, thereby accelerating bone regeneration. Finally, the bionic periosteum exhibits remarkable capabilities in angiogenesis and osteogenesis, demonstrating its potential for bone repair in a rat calvarial defect model.
研究领域:
生物材料
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组织工程
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骨再生
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免疫学
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
MATERIALS LETTERS
·
2024
·
IF 2.7
Sicong Tu,Shuting Mai,Dan Shu,Yuxin Huang,Zhihong Nie,Yang Wang,Wuli Yang
It is challenging for the manufacturing of microspheres loaded with peptide due to the complicated preparation process and the issue of burst release. In this construct, a microfluidic flow-focusing device is developed to prepare and optimize poly (lactic- co -glycolic acid) (PLGA) Exenatide −loaded microspheres. Surfactants was added to greatly improve the stability of the emulsion, leading to increase drug loading capacity. By increasing the particle size of the drug-loaded microspheres to 30 μm, the burst release was significantly reduced. Additionally, multi-channel droplet microfluidic devices are prepared with the capability to achieve a 100-fold increase in throughput, which could achieve a production rate of 2 g per hour.
研究领域:
药剂学
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生物医学工程
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产品关联
DOI
高影响因子
CELLULOSE
·
2024
·Vol. 31
·期 14
·8539-8554
·
IF 4.9
Li Yang,Liu Xiaoyan,Liu Zhongming,Wang Shoujuan,Kong Fangong
The development of effective drug delivery systems is crucial for improving the efficacy of cancer drugs, in order to overcome the issues of low drug loading and drug burst release. Nanocellulose composite aerogel was prepared as a drug carrier for 5-fluorouracil, which had the advantages of three-dimensional network structures, high porosity and good biocompatibility, and its loading capacity was much higher than that of other bio-based drug carriers. Fourier-transform infrared, scanning electron microscopy, X-ray photoelectron spectroscopy, cytotoxicity analysis, and other analytical techniques were used to analyse the physical and chemical structures of nanocellulose composite aerogels. The analysis revealed that the introduction of β-cyclodextrin and sodium hyaluronate led to good compressibility, rich network structure, and abundant adsorption active sites of the nanocellulose composite aerogel, which was more suitable as a drug carrier. The maximum amount of 5-fluorouracil on the nanocellulose composite aerogel through coating and hydrogen bonding reached 486.93 mg/g. The drug release curves of the nanocellulose composite aerogels depended on pH and conformed to the first-order kinetic model and Korsmeyer-Peppas model. Nanocellulose composite aerogels exhibited a high loading capacity and controllable release of 5-fluorouracil, with great potential for biomedical applications. Graphical abstract Nanocellulose composite aerogels for efficient drug loading and sustained release
研究领域:
生物材料学
·
药剂学
·
生物医学工程
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产品关联
DOI
高影响因子
BULLETIN OF THE CHEMICAL SOCIETY OF ETHIOPIA
·
2025
·Vol. 39
·期 4
·749-761
·
IF 2.3
Haochen Wu,Tao Jiang,Xiaohong Chen,Ping Liu
Foodborne illnesses remain a significant concern in the realm of public health. Managing food spoilage and controlling pathogenic microorganisms rely on synthetic chemicals, regrettably accompanied by various unfavourable attributes. In response to the escalating demand for innovative and secure alternative approaches, there has been a surge in the investigation of naturally sourced agents possessing antimicrobial characteristics, among which essential oils stand out. This study focuses on improving the stability of clove essential oil (CEO), and to achieve controlled release, the CEO microcapsules are prepared by solvent evaporation method with ethyl cellulose as the wall material. The results indicated optimum technological conditions: wall material mass fraction of 3%, core wall ratio of 1.0:1.5, emulsifier mass fraction of 8% and shear rate of 14000 r/min. Under these conditions, the encapsulation efficiency is 81.28%, and the yield rate is 90.58%. The CEOM were spherical with a size of 1.43-3.92 μm and had good thermal stability. The microcapsule under 50% ethanol showed a faster release rate and significant release amount. The microencapsulation of CEO with ethyl cellulose can not only improve the stability of CEO but also realise the controlled release of CEO, which has tremendous application value in antibacterial packaging.
Bull. Chem. Soc. Ethiop. 2025, 39(4), 749-761.
DOI: https://dx.doi.org/10.4314/bcse.v39i4.11
研究领域:
食品科学
·
微生物学
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DOI
高影响因子
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
·
2026
·
IF 2.9
Yanyan Guo,Lingyu YAO,Yonghui Duan,Xin Xin,Guiyang Xia,Yuhua Ma,Sheng Lin
Gentiopicroside (GPS) is a natural component with anti-inflammatory, hepatoprotective, and other activities. However, its short half-life and insufficient residence time limit its clinical application. In this study, GPS was identified as a hydrophilic drug based on pre-formulation studies, and two sustained-release preparations were successfully developed, including gentiopicroside microporous osmotic pump tablets (GPS-MPOP) and gentiopicroside matrix sustained-release tablets (GPS-MRT). GPS-MPOP and GPS-MRT were prepared using single-factor experiments. In vitro release studies demonstrated that both preparations exhibited sustained release for 12 h. The release curve followed the Weibull model, and the release mechanism was governed by a combination of diffusion and erosion. In vivo pharmacokinetic study in New Zealand rabbits showed that the Tmax of reference preparations (GPS-OT), GPS-MRT and GPS-MPOP were 0.25 h, 1.00 h (P ≤ 0.01) and 1.50 h (P ≤ 0.01); the Cmax were 1108.11 ± 14.56 μg/L, 714.71 ± 10.24 μg/L (P < 0.0001) and 850.53 ± 4.80 (P < 0.0001) μg/L, and the t1/2 were 1.30 ± 0.07 h, 5.36 ± 1.39 h (P < 0.0001) and 4.86 ± 0.28 (P < 0.0001) h, respectively. Compared with reference preparations, the relative bioavailability was 103.24% for GPS-MRT and 116.47% for GPS-MPOP, respectively. Both of the two sustained-release preparations prolonged drug release and reduced plasma concentration fluctuation, which provides a new strategy for clinical application of GPS.
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DOI
PubMed
高影响因子
POLYMERS FOR ADVANCED TECHNOLOGIES
·
2022
·Vol. 33
·期 10
·3192-3200
·
IF 3.348
Zhicheng Deng,Jinjun Li,Yun Chen,Chao Huang,Nanjing Zhong,Yong Hu
A novel Cur/TPP-β-CD/CS/Vc microparticles (MPs) filled CMCS/OSA composite hydrogel was prepared by dispersed the chitosan/vitamin C (CS/Vc) complex and curcumin/TPP-β-cyclodextrin (Cur/TPP-β-CD) complex in the hydrogel precursor of oxidized sodium alginate (OSA) and carboxymethyl chitosan (CMCS). Structural properties of the MPs/CMCS/OSA composite hydrogel were characterized by Fourier transform infrared, scanning electron microscope, TG, rheological, and texture analyzer. It was found that the polymeric MPs with a diameter of about 2.5 μm were homogenously embedded in the composite hydrogel by hydrogen bonding and electronic force, resulting in obvious enhanced mechanical strength and stability of the MPs hybrid hydrogel. In vitro release studies show that the release of Cur and Vc can be more efficiently controlled by the different encapsulation pathways. Moreover, the preferential release of the Cur than that of Vc has been confirmed by the two-dimensional ultraviolet correlation spectroscopy. Therefore, the MPs/CMCS/OSA composite hydrogel can be used for independently controlled release of dual bioactive compounds during codelivery.
研究领域:
药学
·
材料科学
·
生物技术
·
药物递送系统
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）