ANALYST
·
2018
·Vol. 143
·期 20
·4907-4914
·
IF 3.864
Yufeng Zhou,Yali Yu,Longlong Gao,Yifan Fei,Ting Ye,Qiusha Li,Xiaoshun Zhou,Ning Gan,Yong Shao
Efficient structuring of DNA by small molecules is very crucial in developing DNA-based novel switches with an ideal performance. In this work, we found that inverting only the polarity of the 3′ terminal guanine of the thrombin-binding aptamer (3iTBA) totally eradicates the original TBA G-quadruplex (G4) structure in K+. The unstructured 3iTBA can be further refolded upon specifically interacting with small molecules of natural isoquinoline alkaloids (IAs) due to their fruitful binding patterns with variant nucleic acid structures. We identified that 3iTBA can serve as a topology selector for planar IAs. Nitidine (NIT), owing to the planar aromatic ring and coplanar substituents, is the most efficient to restructure the 3iTBA random coil toward the anti-parallel G4 conformation. However, common metal ions can't realize this structuring. The topology selector competency of 3iTBA toward IAs’ planarity can be visualized using gold nanoparticles (AuNPs) as the chromogenic readout. Our work expands the G4 repertoire by exploring the polarity inversion regulation and provides a new approach to switch nucleic acid structures toward a small molecule structure-sensitive sensor.
研究领域:
生物化学
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分子生物学
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纳米技术
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分析化学
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PubMed
高影响因子
Journal of Materials Chemistry C
·
2021
·Vol. 9
·期 44
·16014-16021
·
IF 7.393
Hui Peng,Yonghao Xiao,Ye Tian,Xinxin Wang,Tao Huang,Tiantian Dong,Yueting Zhao,Jianping Wang,Bingsuo Zou
Recently, zero-dimensional (0D) metal halides have made remarkable achievements in the field of optoelectronics due to their diverse structures and optical performances. Here, we report 0D (TBA)2Cu2I4 (TBA+ = tetrabutylammonium cation) single crystals (SCs), which shows a dual-emission band at 473 and 699 nm and a bright cool-white emission with a high photoluminescence quantum yield (PLQY) of 72.5% at room temperature (RT). The temperature-dependent emission spectra and Raman spectra show that a dual self-trapped exciton (STE) is present in this compound, and the external thermal energy can effectively regulate the population of STEs in the two emitting states, and thus the emission color can be changed from blue at a low temperature (78 K) to a cool-white emission at RT. More specifically, (TBA)2Cu2I4 SCs possess high anti-water stability, and can maintain highly efficient emission even if immersed in water for 24 hours. Also noteworthily, the high thermal stability, air stability and photostability of this component have also been proved.
研究领域:
光电学
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材料科学
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光子学
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DOI
高影响因子
COMPOSITES COMMUNICATIONS
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2026
·
IF 7.7
Yujie Yang,Huixing Lin,Jiaqi Li,Yang Gao,Xiaogang Yao,Haiyi Peng
Efficient thermal management is a critical challenge for next-generation electronics, where conventional polymer-based materials suffer from inherently low thermal conductivity. Inspired by natural honeycomb structures, we developed a freeze-casting strategy to fabricate high-performance hexagonal boron nitride (h-BN)/polysilylaryl-enyne (PSAE) composites exhibiting enhanced thermal conductivity. By leveraging the unidirectional crystallization of tert-butyl alcohol (TBA), a highly ordered h-BN honeycomb scaffold was constructed, facilitating the formation of efficient phonon conduction pathways. The composites, with a low h-BN (10 μm) ratio of 23 vol%, exhibit an outstanding omni-directional thermal conductivity of 4.71 W/(m·K) along the z-axis and 3.44 W/(m·K) along the x-axis, significantly outperforming conventional polymer composites. Moreover, dielectric characterization confirms that the honeycomb structure enhances anisotropic dielectric behavior ( ε rz = 3.68, ε rx = 3.32, for h-BN (10 μm) at 23 vol%). The proposed bioinspired approach presents a scalable and effective route for developing lightweight, thermally conductive composites for advanced electronic applications.
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高影响因子
RSC Advances
·
2021
·Vol. 11
·期 39
·23968-23974
·
IF 3.361
Tianxiang Yin,Xingnan Zhou,Jing Shi
Carbon dots (CDs) have drawn considerable attention in recent decades due to their outstanding biocompatibility and environmental friendliness. In this study, we synthesized ionic liquid (1-aminopropyl-3-methyl-imidazolium bromide)-modified carbon dots (IL-CDs) showing good peroxidase-like activity. Furthermore, we investigated their enzymic behavior in the presence of two different amphiphilic molecules, namely tert-butanol (TBA, a typical hydrotrope) and sodium bis (2-ethylhexyl) sulfosuccinate (AOT, a typical anionic surfactant). In an aqueous solution of TBA, a microscopic heterogeneous structure was formed in a certain concentration range of TBA, which resulted in an anomaly in the reaction process. However, in the AOT aqueous solution, the situation became more complicated. IL-CDs formed vesicles or precipitation at different concentrations of AOT, which led to different enzymic activities of IL-CDs due to the variance in the structure and the surface electronic density.
研究领域:
纳米材料
·
生物化学
·
环境科学
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DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
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2023
·
IF 15.1
Jin Huang,Hao Wang,Chunyang Chen,Yizhe Tang,Husheng Yang,Shengzhong Liu,Dan Zhang
All-inorganic CsPbI 3 perovskite solar cells (PSCs) play a significant role in the new generation photovoltaic technology because of their unique optical band gap and excellent light absorption performance. However, the generation of defect states during the fabrication will cause serious non-radiative recombination and film degradation. Therefore, a new organic additive 4-Thioureidobenzoic acid (4-TBA) was introduced to decrease the defect density and optimize the device performance in this work. Thiourea group and carboxyl group in 4-TBA could not only be anchored on the film surface to passivate uncoordinated Pb 2+ defects as bilateral Lewis base, but also form the adjustable skeleton at the grain boundaries to fill Cs + vacancies, support perovskite framework, boost the charge transfer and enhance the film crystallinity. Owning to the hydrophobicity of benzene ring structure of 4-TBA, the hydrophobic protective layer could be formed on the film surface and grain boundary to isolate the damage of external moisture to the device. Furthermore, with the release of residual stress in the film, the stability of device is substantially improved. Eventually, the 0.02 mol% 4-TBA based device prepared by one-step spin-coating method possesses an ultra-high power conversion efficiency (PCE) of 20.26%, which is one of the greatest efficiencies of all-inorganic CsPbI 3 PSC at present. Surprisingly, after 1000 h of environmental stability test, the optimized device still maintains 95.6% of original efficiency without encapsulation, and the PCE attenuation is only 4.4%, showing excellent long-term stability.
研究领域:
材料科学
·
能源技术
·
光伏器件
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高影响因子
TALANTA
·
2020
·
IF 5.339
Hong Chen,Xiaojun He,Yuzhong Yu,Yuna Qian,Jianliang Shen,Shanchao Zhao
Hypochlorite (ClO − ) could be used as a diagnostic marker for inflammation and related diseases. Although there have been many reports on probes for ClO − imaging, there was still a lack of specificity and anti-interference ability. Herein, carbazole (NEC) and tetraphenylethylene (TPE) equipped with thiobarbituric acid (TBA), NEC-TBA and TPE-TBA , were synthesized and used as a fluorescence biosensor for monitoring ClO − with aggregation-induced emission (AIE) effect. we identified that TPE-TBA , with formed nanoparticles in the mean grain size at 76 nm (5 μM), was a superior probe to target ClO − over other analytes with fluorescence “turn off” strategy. Subsequently, to explore the bioimaging application, TPE-TBA was able to sense exogenous ClO − in living HeLa cells through fluorescence imaging. In zebrafish model, TPE-TBA effectively captured exogenous ClO − in the entire organization of zebrafish. Overall, these AIE-based probes merit further development as organism targeting ClO − sensors.
研究领域:
生物化学
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细胞生物学
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分子生物学
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DOI
PubMed
高影响因子
Science China-Chemistry
·
2026
·
IF 9.8
Huang Kuniadi Wandy,Vo Dat-Nguyen,Yin Xunyuan
Shipboard CO 2 capture (SCC) systems using MEA/[TBA][Br] solvent lack experimental studies and efficient data-driven optimization frameworks that minimize regeneration energy while maintaining high CO 2 capture rates. This study conducts cyclic experiments and develops a deep neural network (DNN)-based framework to optimize operating conditions for shipboard-relevant carbon capture. In the first stage, 70 experimental samples are collected under varying [TBA][Br] concentration, desorber temperature, and liquid-to-gas (L/G) ratio to train a surrogate DNN model. This model is used to formulate an optimization problem, from which an optimal operating zone is identified. In the second stage, 28 additional experiments are performed within this operating zone, and the full 98-sample dataset is used to train a refined DNN model, featuring three hidden layers with hyperparameters tuned via grid search and evaluated using an 80−20 training-test split. Optimization using the refined DNN identifies the optimal condition at [TBA][Br] concentration of 2.96 wt%, a desorber temperature of 120 C, and an L/G ratio of 1.73 kg/kg, corresponding to more than 90% CO 2 capture and a regeneration energy of 2.94 GJ/t CO 2 . This optimal performance corresponds to an 11.40%–34.87% reduction in regeneration energy compared to baseline MEA in this study and MEA-based SCC systems from the literature. The refined DNN demonstrates strong predictive capability, achieving MAPE values of 1.27% (training) and 1.41% (test) for CO 2 capture rate, and 0.83% (training) and 1.04% (test) for regeneration energy. Sensitivity analysis highlights the influence of all three variables: [TBA][Br] addition reduces sensible and vaporization heat requirements, higher L/G ratios improve CO 2 capture rates, and elevated desorber temperatures simultaneously enhance CO 2 capture rates and lower regeneration energy. Moreover, ATR-FTIR analysis over 15 cycles confirms solvent chemical stability with no evidence of chemical degradation. This work demonstrates an effective machine learning-enabled optimization strategy for SCC with MEA/[TBA][Br] solvent and offers insights into developing energy-efficient SCC systems and a framework extendable to other CO 2 emission sources.
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高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2025
·
IF 9
Xueying Cheng,Meirun Lu,Zhengkai Wu,Renquan Guan,Qingkun Shang
The efficient photocatalytic eliminate of persistent pollutants is crucial for advancing photocatalytic technology in environment applications. Constructing efficient heterojunction photocatalysts represents a key strategy for prolonging the lifetime of photo generated charge carriers and enhancing photocatalytic performance. In this study, an In 2 S 3 /TiO 2 -2:1 defect-heterojunction photocatalyst was developed, which exhibited exceptional degradation ability for recalcitrant contaminants including trenbolone acetate (TBA), acetaminophen, and phenol. Remarkably, over 99 % of TBA was degraded in 30 min, with comprehensive environmental risk assessment confirming minimal ecological impact from degradation intermediates. Transient fluorescence spectroscopy and transient surface photovoltage spectroscopy were performed to evaluate the relaxation process of photogenerated carriers. The results showed that the carrier relaxation time of In 2 S 3 /TiO 2 -2:1 defect-heterojunction photocatalyst was significantly prolonged, which effectively promoted the photocatalytic activity. This study provides valuable references for the design and development of high-performance defect-heterojunction photocatalysts.
研究领域:
环境科学
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材料科学
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光催化
·
化学工程
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DOI
高影响因子
JOURNAL OF POLYMER RESEARCH
·
2023
·Vol. 30
·期 9
·1-8
·
IF 2.8
Qiao Xiaoguang,Dong Xin,shi Ge,He Yanjie,Pang Xinchang
The postsynthesis polymeric modifications by grafting from the active sites were the primary focus of the structurally tailored and engineered macromolecular (STEM) gels. Therefore, Reversible-deactivation radical polymerization (RDRP) techniques have been employed to more precisely tailor and tune STEM gels. In contrast to atom transfer radical polymerization (ATRP) and reversible addition-fragmentation chain transfer polymerization (RAFT), nitroxide-mediated polymerization (NMP) is known to have the advantages of simple components and pure products. Here we report the preparation of polydimethylsiloxane (PDMS) composite gel networks through oxygen tolerance NMP process, with tert-Butyl acrylate (tBA) and fluorinated monomer 2-(Perfluorooctyl)ethyl methacrylate (FMA) as functional comonomers. Compared with conventional radical polymerization (FRP) method, composite gels prepared through NMP method showed higher swelling rate and elongation at break, which proved that the network structure formed by NMP was more uniform. In addition to better thermal stability and toughness, the dormant polymer chain could be reactivated and lead to the “living” post-modification of PDMS gel matrix.
研究领域:
材料科学
·
高分子化学
·
材料工程
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DOI
高影响因子
JOURNAL OF ETHNOPHARMACOLOGY
·
2024
·
IF 4.8
Zhiyuan Zhang,Guoqiang Guan,Zixuan Tang,Weimin Wan,Zhipeng Huang,Yuefeng Wang,Jianzhao Wu,Bo Li,Mingli Zhong,Kefeng Zhang,Lixian Nong,Ya Gao,Houkang Cao
A B S T R A C T Ethnopharmacological relevance Cholestatic liver disease (CLD) is a disease characterized by cholestasis. Farnesoid X receptor (FXR) is a nuclear receptor that maintains homeostasis in bile acid metabolism. Studies have shown that gut microbiota interfered with the FXR pathway. Modulation of FXR to inhibit cholestasis has become a key measure in the treatment of CLD. In traditional folk medicine, Desmodium styracifolium (Osb.) Merr. was used as a primary treatment for gallstones, gonorrhea, jaundice, cholecystitis and other diseases. Modern pharmacological studies had also found that the herb has anti-calculus, anti-inflammatory, antioxidant, diuretic and liver damage. Therefore, we speculated that Desmodium styracifolium (Osb.) Merr. extracts (DME) could alleviate CLD through the FXR pathway and might be associated with the gut microbiota. However, studies of DME alleviating CLD through the FXR pathway have not been reported. Aim of study To study the effect and mechanism of DME in relieving CLD through in vivo and in vitro experiments. Materials and methods First, mice were administrated with alpha-naphthyl isothiocyanate (ANIT) to establish a CLD model in vivo . Meanwhile, HepG2 cells were induced by lithocholic acid (LCA) to establish the CLD model in vitro . To evaluate the therapeutic effect of DME on CLD mice, hematoxylin-eosin (HE) staining, and biochemical indicators were performed. The prototype of the blood components in mice serum was detected by ultra-high-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). 16S rDNA sequencing was used to analyze the gut microbiota. Finally, the protein and mRNA expression of the FXR pathway in mice liver tissues or HepG2 cells were detected by Western blot, qRT-PCR, or immunofluorescence. Results Pathological testing and biochemical indexes showed that DME significantly reduced serum ALT, AST, ALP, TBIL, DBIL, TBA and liver TBA levels, and attenuated liver tissue injury, necrosis and jaundice in CLD mice. In addition, MetagenomeSeq analysis of gut microbiota showed that DME significantly up-regulated the abundance of Parvibacter , down-regulated the abundance of Paenalcaligenes , and regulated bile acid homeostasis. In terms of mRNA expression, DME significantly upregulated the mRNA levels of Nr1h4, Abcb11, Cyp7a1 and Slc10a1. Meanwhile, in terms of protein expression, DME significantly up-regulated the protein expression levels of FXR, BSEP, CYP7A1 and NTCP, which regulated bile acid homeostasis. Finally, the molecular docking results showed that the components of DME, such as Lumichrome, Daidzein and Folic acid, all had good binding ability with FXR, and the surface plasmon resonance (SPR) results also showed that both Lumichrome and Daidzein had a relatively high affinity with FXR. Conclusion DME alleviated CLD through the FXR pathway, and the mechanisms might be associated with the gut microbiota.
研究领域:
药理学
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肝病学
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分子生物学
·
微生物学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF ETHNOPHARMACOLOGY
·
2024
·
IF 4.8
Guoqiang Guan,Houkang Cao,Zixuan Tang,Kefeng Zhang,Mingli Zhong,Rui Lv,Weimin Wan,Fengyue Guo,Yongwang Wang,Ya Gao
Ethnopharmacological relevance Polygala fallax Hemsl. is a traditional folk medicine commonly used by ethnic minorities in the Guangxi Zhuang Autonomous Region, and has a traditional application in the treatment of liver disease. Polygala fallax Hemsl . polysaccharides (PFPs) are of interest for their potential health benefits. Aim of this study This study explored the impact of PFPs on a mouse model of cholestatic liver injury (CLI) induced by alpha-naphthyl isothiocyanate (ANIT), as well as the potential mechanisms. Materials and methods A mouse CLI model was constructed using ANIT (80 mg/kg) and intervened with different doses of PFPs or ursodeoxycholic acid. Their serum biochemical indices, hepatic oxidative stress indices, and hepatic pathological characteristics were investigated. Then RNA sequencing was performed on liver tissues to identify differentially expressed genes and signaling pathways and to elucidate the mechanism of liver protection by PFPs. Finally, Quantitative real-time polymerase chain reaction (qRT-PCR) and Western blotting were used to verify the differentially expressed genes. Results Data analyses showed that PFPs reduced the levels of liver function-related biochemical indices, such as ALT, AST, AKP, TBA, DBIL, and TBIL. PFPs up-regulated the activities of SOD and GSH, down-regulated the contents of MDA, inhibited the release of IL-1β, IL-6, and TNF-α, or promoted IL-10. Pathologic characterization of the liver revealed that PFPs reduced hepatocyte apoptosis or necrosis. The RNA sequencing indicated that the genes with differential expression were primarily enriched for the biosynthesis of primary bile acids, secretion or transportation of bile, the reactive oxygen species in chemical carcinogenesis, and the NF-kappa B signaling pathway. In addition, the results of qRT-PCR and Western blotting analysis were consistent with those of RNA sequencing analysis. Conclusions In summary, this study showed that PFPs improved intrahepatic cholestasis and alleviated liver damage through the modulation of primary bile acid production, Control of protein expression related to bile secretion or transportation, decrease in inflammatory reactions, and inhibition of oxidative pressure. As a result, PFPs might offer a hopeful ethnic dietary approach for managing intrahepatic cholestasis.
研究领域:
药理学
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分子生物学
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肝病学
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民族药理学
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DOI
PubMed
高影响因子
CHEMOSPHERE
·
2017
·
IF 4.208
Ziying Wang,Yisheng Shao,Naiyun Gao,Xian Lu,Na An
Degradation of diethyl phthalate (DEP) by ultraviolet/persulfate (UV/PS) process at different reaction conditions was evaluated. DEP can be degraded effectively via this process. Both tert-butyl (TBA) and methanol (MeOH) inhibited the degradation of DEP with MeOH having a stronger impact than TBA, suggesting sulfate radical ( ) and hydroxyl radical (HO ) both existed in the reaction systems studied. The second-order rate constants of DEP reacting with and HO were calculated to be ( 6.4 ± 0.3 ) × 10 7 M −1 s −1 and ( 3.7 ± 0.1 ) × 10 9 M −1 s −1 , respectively. To further access the potential degradation mechanism in this system, the pseudo-first-order rate constants (k o ) and the radical contributions were modeled using a simple steady-state kinetic model involving and HO . Generally, HO had a greater contribution to DEP degradation than . The k o of DEP increased as PS dosages increased when PS dosages were below 1.9 mM. However, it decreased with increasing initial DEP concentrations, which might be due to the radical scavenging effect of DEP. The k o values in acidic conditions were higher than those in alkaline solutions, which was probably caused by the increasing concentration of hydrogen phosphate (with higher scavenging effects than dihydrogen phosphate) from the phosphate buffer as pH values rose. Natural organic matter and bicarbonate dramatically suppressed the degradation of DEP by scavenging and HO . Additionally, the presence of chloride ion (Cl − ) promoted the degradation of DEP at low Cl − concentrations (0.25–1 mM). Finally, the proposed degradation pathways were illustrated.
研究领域:
环境化学
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水处理
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高级氧化过程
·
污染物降解
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DOI
高影响因子
危险品化学品经营许可证（带存储）