The equilibrium solubility of teflubenzuron in solvent mixtures of methanol (1) + water (2), ethanol (1) + water (2), propylene glycol (1, PG) + water (2), and N,N-dimethylformamide (1, DMF) + water (2) was determined experimentally by an isothermal dissolution equilibrium method within the temperature ranging from 278.15 to 323.15 K under an atmospheric pressure of 101.1 kPa. The solubility of teflubenzuron increased monotonously with the increase in mass fraction of methanol, ethanol, PG, and DMF and temperature. At the same temperature and mass fraction of methanol (ethanol, PG, and DMF), the mole fraction solubility of teflubenzuron is greater in DMF + water than in the other three solvent mixtures. Besides, the solubility of teflubenzuron was correlated with three models. The obtained average relative deviation (RAD) is lower than 0.41% for correlative studies. It is noteworthy that the solubility data presented in this work contributes to expansion of the physicochemical information about the solubility of drugs in binary solvent mixtures and also allows the thermodynamic analysis of the respective dissolution.
Liu Yang,Yu-Long Liu,Xian-Xian Ji,Cheng-Guo Liu,Ying Fu,Fei Ye
Background A novel luminescent sensor with dual-emitting platforms, Tb@UiO-66 , was used for highly detecting Sm 3+ and teflubenzuron. Methods Tb@UiO-66 was synthesized on basis of the exchange of guest molecules, where Tb 3+ ions were encapsulated into the cages of UiO-66 . Significant finds The results of multiband fluorescence originated from the linker-to-cluster charge transfer and the characteristic emission of Tb III . Tb@UiO-66 displayed luminescence enhancements or quenches according to small molecules. Especially for Sm 3+ and teflubenzuron, the characteristic peaks of Tb@UiO-66 at 490, 545, 585, and 621 nm increased with the increasing of the concentration of the analytes, where Tb@UiO-66 exhibited the effect of luminescence enhancement. The detection limits for detecting Sm 3+ and teflubenzuron were 0.09 μM and 0.21 μM, and the changes of luminescence intensities could be observed by naked eyes under the UV light at 365 nm. Tb@UiO-66 could also be used to detect teflubenzuron in real water samples. Tb@UiO-66 could be reused for at least 5 cycles for the detection of Sm 3+ and teflubenzuron with the framework of Tb@UiO-66 uncollapsed. These results implied that the integration of Ln III luminescent materials and Zr-MOFs by doping method provided a new strategy for fabricating novel luminescent sensors for detecting polluting small molecules.
A novel nanocomposite fluorescent probe consisting of quantum dots and a silica molecularly imprinted polymer (MIPs-capped ZnS:Mn QDs) was synthesized and applied for the rapid detection of teflubenzuron (TBZ) based on the fluorescence quenching of a composite probe via TBZ. The fluorescence quenching efficiency of MIP@SiO2@ZnS:Mn QDs displayed a linear relationship over the concentration range of 0–26.24 μmol/L with a correlation coefficient of 0.9857 and the limit of detection was 2.4 μg/L. The selectivity test showed that the nanocomposite had good selectively rebind TBZ with higher imprinting factor of 3.06 compared with four structurally similar compounds. In addition, the probe was successfully applied to the detection of TBZ in vegetable samples with a recovery of 90.3~97.1% and with a relative standard deviation below 3.2%. This developed method has the advantages of simple preparation, fast response and low toxicity for trace TBZ detection.
危险品化学品经营许可证（带存储）