MEASUREMENT
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2025
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IF 5.6
Xu-guang Hu,Zhan-kun Li,Ju-wei Zhang,Xi-xin Wang,Xiao-ming Chen,Yong Zhao
A label-free fiber-optic optofluidic biosensor integrated into microfluidic chip based on vernier effect is proposed for the specific and high-sensitivity detection of DNA molecules, which is made up of a Michelson interferometer (MI) and a Fabry Perot interferometer (FPI) in parallel. The MI is prepared by a single-hole dual-core micro-structured fiber (MOF) with a suspended core attached to the hole serving as the sensing arm, and used as the sensing element. A micropore is etched directly above the microchannel of MI as the fluid inlet by femtosecond laser processing, and integrated into the microfluidic chip for sample replacement. The detection volume is only nanoliters and the sample can be quickly replaced within seconds. The experimental findings indicate that the proposed optofluidic sensor shows a high refractive index (RI) sensitivity of −8791 nm/RIU and has an ultra-low detection limit of 7.45 × 10 −6 RIU within the range of 1.3328–1.3370. By immobilizing probe DNA (pDNA) molecules on the suspended core through surface functionalization, the optofluidic sensor enables label-free detection of 1 μM complementary DNA (cDNA) solution and shows excellent specificity. The proposed fiber optofluidic biosensor has great development prospects in ultra-low volume and high-sensitivity detection of biomolecules.
研究领域:
生物医学工程
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光学工程
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分子生物学
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产品关联
DOI
高影响因子
SENSORS
·
2025
·Vol. 25
·期 3
·920
·
IF 3.5
Ning Wang,Shiqi Liu,Liang Xu,Longjiao Wang,Ming He,Chuanjie Lei,Linyufan Xiao
This work proposes an optical fiber copper ion sensor, which is fabricated by an ion-imprinted sodium alginate/graphene oxide (SA/GO) hydrogel and single-mode fiber (SMF). This sensing Fabry–Perot Interferometer (FPI) achieves −1.98 nm/(mg/L) sensitivity with 0.998 linearity. To achieve higher sensitivity, we add a reference FPI to create a Vernier effect. We achieve 19.58 nm/mg/L sensitivity and 0.989 linearity at a concentration range of 0 mg/L–1.4 mg/L. It was 9.9 times higher than that of a single-sensing FPI. The experimental results also demonstrate that when the FSR values of two FPIs are closer, the higher response sensitivity is achieved. The sensor also has good measurement repeatability and dynamic response. In addition, the experimental results of response selectivity show that its response sensitivity to copper ions is significantly higher than other six types of ions, including iron ions, lead ions, magnesium ions, manganese ion, zinc ions, chromium ions. The copper ion is also mixed with six types of ions to deeply investigate the response selectivity. Good response selectivity and cross-responding are demonstrated by experimental results.
研究领域:
材料科学
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光学传感
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环境监测
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产品关联
DOI
PubMed
高影响因子
IEEE SENSORS JOURNAL
·
2024
·
IF 4.3
Jie Liu,Yinping Miao,Xiaolan Li,Mingpan Bi,Yanxi Wang,Yang Zhang
Streptomycin sulfate (STS) is one of the major sources of contamination in water. Excessive intake of STS can be a serious health hazard to humans, causing vestibular and auditory nerve damage, nephrotoxicity, myasthenia gravis or Parkinson’s disease. To address this, we propose an STS concentration sensor leveraging multiwalled carbon nanotubes (MWCNTs) and the vernier effect of a microfiber coupler (MFC). The vernier effect of MFC is caused by the interference of two supermodes in two orthogonal polarizations in a refringent optical fiber, and the high sensitivity can be achieved directly by monitoring the vernier envelope. MWCNTs can adsorb more biomolecules to enhance the light absorption of analytes to further improve the detection sensitivity. The influence of MFC structure parameters on sensor performance is analyzed by simulation and verified by experiment. Theoretical analyses and experimental results indicate that for specific diameter MFC, the sensor will have better performance. The sensor exhibits a remarkably high sensitivity of 1577.5 nm/(mg/ml) in the detection range of 0.02-0.1 mg/ml, namely sensitivity amplification factor nearly one order of magnitude, and the sensor achieves an ultralow limit of detection of 12.68 ng/ml. The vernier effect of MFC and the modification of MWCNTs effectively enhance the sensitivity of the STS sensor. The device does not require complex pretreatment or antibody preparation, making it highly promising for applications in food safety, environmental pollution, and health monitoring.
研究领域:
生物医学工程
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环境科学
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光学传感
✓ 已验证
DOI
高影响因子
MEASUREMENT
·
2024
·
IF 5.2
Bin Yin,Zhuxuan Jiang,Shilin Liu,Guofeng Sang,Yanzhi Lv,Muguang Wang,Shiying Xiao,Beilei Wu,Qichao Wang,Li Pei,Songhua Wu
A composite Fabry-Perot (F-P) fiber optic sensor based on the vernier effect is fabricated, and experiments confirmed that it can be used to simultaneously measure underwater temperature and pH. The fiber optic sensor fabricated with single mode fiber (SMF) − multi mode fiber (MMF) − seven core fiber (SCF) − quartz capillary tube (QCT) − no core fiber (NCF) structures has contained a silane coupling agent-polyvinyl alcohol/graphene oxide (SCA-PVA/GO) hybrid multilayer film to enhance the sensor performance. Two types of sensors are fabricated, one with a plane end face and another with a tapered end surface, which named as sensor 1 and sensor 2, respectively. Their performance are experimentally demonstrated. Within the temperature range of 15°C-35°C and the pH range of 7.55–9.21, the sensitivities of sensor 1 to temperature and pH are 82.94 pm/°C and 1.16 dB/pH, while the corresponding values of sensor 2 are 39.26 pm/°C and 0.4 dB/pH. Experimental results demonstrated that the sensitivities of sensor 1 to temperature and pH are higher than that of sensor 2. But compared with sensor 2, sensor 1 has higher values of crosstalk and random error. By contrast, sensor 2 maintain a good linear relationship with the environmental dual parameters, allowing for the simultaneous measurement of underwater temperature and pH. Moreover, both sensors demonstrate good stability and reversibility when the temperature and pH are varied. Furthermore, the pH response times of the two sensors are less than 0.5 s, with a recovery time of 2 s. Thus, the proposed sensors with outstanding stability, reversibility, repeatability, and rapid response times will have a broad range of applications in the fields of marine environment monitoring, water quality detection, and food and medical device safety testing.
研究领域:
海洋环境监测
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水质量检测
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光学传感
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材料科学
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产品关联
DOI
高影响因子
OPTICAL FIBER TECHNOLOGY
·
2021
·
IF 2.53
Changgui Yu,Huaping Gong,Zhaoxu Zhang,Kai Ni,Chunliu Zhao
In this paper, a relative humidity (RH) sensor based on vernier effect of two parallel Fabry-Perot interferometers is proposed and experimentally demonstrated. The polyvinyl alcohol (PVA) is chosen as the humidity sensitive material. The sensor consists of a reference cavity formed by single mode fiber – fiber capillary - single mode fiber (SMF-FC-SMF) structure and a sensing cavity formed by SMF-FC-coated structure. The sensor shows the high sensitivity of 1.78 nm/%RH in the range of 55%RH-85%RH. We measured the stability of the sensor at 45%RH and 75%RH, and the response time between 55%RH and 75%RH is 12 s. In addition, it also has the advantages of low temperature disturbance, simple principle, and easy manufacture.
研究领域:
光学传感
·
材料科学
✓ 已验证
DOI
高影响因子
OPTICAL FIBER TECHNOLOGY
·
2023
·
IF 2.7
Yiting Liu,Huaping Gong,Xiao Lu,Kai Ni,Chunliu Zhao,Changyu Shen
An optical fiber humidity sensor based on vernier effect of Fabry-Perot(F-P) interferometers constructed by microsphere and polyvinyl alcohol (PVA) film is proposed. A hollow capillary fiber (HCF) is spliced with the single-mode fiber (SMF), and the barium titanate ball is inserted into the HCF. A layer of PVA film is coated on the end face of the HCF to construct multiple F-P cavities, and two F-P cavities act as the reference cavity and sensing cavity. The lengths of the two cavities are relatively close to form the vernier effect. The experimental results show that the humidity sensitivity of the sensor is 0.316 nm/%RH in the range of 35 %RH-85 %RH. The fluctuation of the sensor in 60 min is less than 0.27 %RH. And the response time of the sensor is about 12 s. The sensor has the merits of high sensitivity, compact size and good stability.
研究领域:
光学传感
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2018
·
IF 5.667
Kaiwei Li,Nan Zhang,Nancy Meng Ying Zhang,Wenchao Zhou,Ting Zhang,Ming Chen,Lei Wei
We report a simple and effective method to improve the sensitivities of fiber-optic modal interferometers with birefringence induced Vernier effect. Taking optical microfiber coupler as an example, we study the sensitivity enhancement of a microfiber coupler for refractive index (RI) sensing both theoretically and experimentally in the RI range of 1.33–1.35 where bioassays are typically carried out. Numerical results show that by tracing the wavelength shifts of dips in the envelope formed by the Vernier effect, RI sensitivities can be improved by almost one order of magnitude compared to the sensors without the Vernier effect. Then we experimentally achieve an ultra-high sensitivity of 35,823.3 nm/RIU using a microfiber coupler with a width of 3.2 μm. More importantly, we apply this ultra-sensitive sensor to detect human cardiac troponin, and a limit of detection of 1 ng/mL is achieved. This sensor is simple in configuration andcan serve as a bio-photonic platform for clinical diagnostics environmental monitoring and food safety.
研究领域:
光学传感器
·
生物医学工程
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产品关联
DOI
高影响因子
OPTICAL FIBER TECHNOLOGY
·
2025
·
IF 2.7
Ling Chen,Ruike Liu,Xianfeng Liu,Zhaoyang Li,Guohao Li
A highly economical fiber immunosensor with the harmonic Vernier effect (HVE) is reported for cancer antigen 125 (CA125) tumor marker detection. The sensor architecture is constructed using a special fiber fusion splicer to cascade three sections of single-mode fiber (SMF) in sequence with a large offset. This configuration yields a cascaded Fabry-Perot interferometer (FPI) architecture incorporating the HVE. The misalignment fusion design facilitates direct and seamless interaction between biochemical fluids and optical signals. Experimental results demonstrate that the refractive index sensitivities of the internal envelope and upper envelope reach −5236, and 1163 nm/RIU, respectively, when refractive index increases from 1.334 to 1.339. It has excellent consistency with the simulation results of −5375 nm/RIU and 1257 nm/RIU as refractive index increases from 1.334 to 1.335. Obviously, the refractive index sensitivity is significantly enhanced via the HVE. The designed sensor is further biologically modified with the 50 μg/mL ovarian cancer 125 monoclonal antibody, enabling varying cancer antigen 125 concentrations detection. The proposed biosensor has low detection limit with value of 44.12 fg/mL and a fast response time (<30 min). Therefore, the proposed biosensor has latent application as an ideal platform for disease diagnosis and medical detection.
研究领域:
生物传感器
·
生物光子学
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癌症诊断
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光学传感
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光纤技术
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生物医学工程
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免疫传感器
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）