Recombinant IMPDH2 Antibody

功能和特点

规格或纯度: Recombinant (R06-1B8); Rabbit anti Human IMPDH2 Antibody; WB, IHC, ICC, IF; Unconjugated
简短描述: Rabbit recombinant (R06-1B8) to IMPDH2
反应种属:
亚型: Rabbit IgG

有货

库存信息

关闭

库存信息

关闭

库存信息

关闭

库存信息

关闭

货号 (SKU)	包装规格	是否现货
Ab110516-10μl	10μl	期货
Ab110516-50μl	50μL	现货
Ab110516-100μl	100μL	现货
Ab110516-1ml	1ml	期货

Skip to the end of the images gallery

Skip to the beginning of the images gallery

基本信息

产品名称	Recombinant IMPDH2 Antibody
别名	重组 IMPDH2 抗体 \| IMPDH2 重组抗体 \| 兔抗人 IMPDH2 抗体 \| 兔抗人 IMPDH2 重组抗体 \| IMPDH2 抗体 \| 5'肌苷磷酸脱氢酶2重组兔单克隆抗体 \| IMPDH2抗体
英文别名	IMDH2_HUMAN antibody \| IMP (inosine monophosphate) dehydrogenase 2 antibody \| IMP dehydrogenase 2 antibody \| IMP oxireductase 2 antibody \| IMPD 2 antibody \| IMPD2 antibody \| IMPDH 2 antibody \| IMPDH II antibody \| IMPDH-II antibody \| Impdh2 antibody \| Inos
规格或纯度	Recombinant (R06-1B8); Rabbit anti Human IMPDH2 Antibody; WB, IHC, ICC, IF; Unconjugated
特异性	IMPDH2
免疫原	A synthetic peptide derived from human IMPDH2 (AA 140-154).
阳性对照	WB: Ramos, K562, MCF7, Hep G2, C6, A549,HeLa and NIH/3T3 cell lysates. IHC: Human breast cancer tissue. ICC/IF: HeLa cells.
偶联标记	1

产品属性

克隆	1
克隆号	R06-1B8
Format	Whole IgG
亚型	Rabbit IgG
SDS-PAGE	150 kDa
纯化方法	Antigen affinity purified
物理外观	Liquid
储存缓冲液	50mM Tris-Glycine, 150mM NaCl, 40% Glycerol, 0.05% BSA, 0.01% Sodium azide, pH 7.4.
防腐剂	0.01% Sodium azide
浓度	0.2 mg/mL
储存温度	-20°C储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	Store at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.

应用

Application	Notes
WB	1/500-1/1000
IHC	1/50 - 1/100
ICC/IF	1/50-1/200

质检证书(COA)

质检报告(COA)

输入批号以搜索COA:

图片

Western Blot: Recombinant IMPDH2 Antibody (Ab110516)

Recombinant IMPDH2 Antibody (Ab110516) - Western Blot
All lanes: Recombinant IMPDH2 Antibody (Ab110516) at 1/1000 dilution
Samples: Lysates at 20 µg per lane
Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution

Predicted band size: 56 kDa
Observed band size: 55 kDa
Exposure time: 1.0 s

IHC: Recombinant IMPDH2 Antibody (Ab110516)

Recombinant IMPDH2 Antibody (Ab110516) - IHC
Immunohistochemistry analysis of paraffin-embedded Human breast cancer using Recombinant IMPDH2 Antibody (Ab110516). High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

IF: Recombinant IMPDH2 Antibody (Ab110516)

Recombinant IMPDH2 Antibody (Ab110516) - IF
Immunocytochemistry analysis of IMPDH2 (green) in HeLa cells using Recombinant IMPDH2 Antibody (Ab110516) and cells were counterstained with DAPI (blue).

产品问答

登录提交问题

查看全部

您提交该产品问题后,我们会在1-2个工作日内给您答复,您可以登录"我的账号",然后点击"我的产品问答"查看答案

参考文献

1. Elgemeie GH. (2003) Thioguanine, mercaptopurine: their analogs and nucleosides as antimetabolites.. Curr Pharm Des, 9 (31): (2627-42). [PMID:14529546]
2. Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M. (2009) Lysine acetylation targets protein complexes and co-regulates major cellular functions.. Science, 325 (5942): (834-40). [PMID:19608861]
3. Tan L, Gurbani D, Weisberg EL, Jones DS, Rao S, Singer WD, Bernard FM, Mowafy S, Jenney A, Du G et al.. (2017) Studies of TAK1-centered polypharmacology with novel covalent TAK1 inhibitors.. Bioorg Med Chem, 25 (4): (1320-1328). [PMID:28038940]
4. Liqiang Chen,Riccardo Petrelli,Magdalena Olesiak,Daniel J Wilson,Nicholas P Labello,Krzysztof W Pankiewicz. (2008-06-28) Bis(sulfonamide) isosters of mycophenolic adenine dinucleotide analogues: inhibition of inosine monophosphate dehydrogenase.. Bioorganic & medicinal chemistry, 16 ((15)): (7462-7469). [PMID:18583139]
5. Sharon Gauci,Andreas O Helbig,Monique Slijper,Jeroen Krijgsveld,Albert J R Heck,Shabaz Mohammed. (2009-05-06) Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.. Analytical chemistry, 81 ((11)): (4493-4501). [PMID:19413330]
6. Liqiang Chen,Daniel J Wilson,Yanli Xu,Courtney C Aldrich,Krzysztof Felczak,Yuk Y Sham,Krzysztof W Pankiewicz. (2010-05-25) Triazole-linked inhibitors of inosine monophosphate dehydrogenase from human and Mycobacterium tuberculosis.. Journal of medicinal chemistry, 53 ((12)): (4768-4778). [PMID:20491506]
7. Maurya SK, Gollapalli DR, Kirubakaran S, Zhang M, Johnson CR, Benjamin NN, Hedstrom L, Cuny GD.. (2009) Triazole inhibitors of Cryptosporidium parvum inosine 5'-monophosphate dehydrogenase.. J Med Chem, 52 (15): (4623-4630). [PMID:19624136]
8. Felczak K, Chen L, Wilson D, Williams J, Vince R, Petrelli R, Jayaram HN, Kusumanchi P, Kumar M, Pankiewicz KW.. (2011) Cofactor-type inhibitors of inosine monophosphate dehydrogenase via modular approach: targeting the pyrophosphate binding sub-domain.. Bioorg Med Chem, 19 (5): (1594-1605). [PMID:21324702]
9. Kirubakaran S, Gorla SK, Sharling L, Zhang M, Liu X, Ray SS, Macpherson IS, Striepen B, Hedstrom L, Cuny GD.. (2012) Structure-activity relationship study of selective benzimidazole-based inhibitors of Cryptosporidium parvum IMPDH.. Bioorg Med Chem Lett, 22 (5): (1985-1988). [PMID:22310229]
10. Gorla SK, Kavitha M, Zhang M, Liu X, Sharling L, Gollapalli DR, Striepen B, Hedstrom L, Cuny GD.. (2012) Selective and potent urea inhibitors of cryptosporidium parvum inosine 5'-monophosphate dehydrogenase.. J Med Chem, 55 (17): (7759-7771). [PMID:22950983]
11. Gorla SK, Kavitha M, Zhang M, Chin JE, Liu X, Striepen B, Makowska-Grzyska M, Kim Y, Joachimiak A, Hedstrom L, Cuny GD.. (2013) Optimization of benzoxazole-based inhibitors of Cryptosporidium parvum inosine 5'-monophosphate dehydrogenase.. J Med Chem, 56 (10): (4028-4043). [PMID:23668331]
12. Nathubhai A, Wood PJ, Lloyd MD, Thompson AS, Threadgill MD.. (2013) Design and Discovery of 2-Arylquinazolin-4-ones as Potent and Selective Inhibitors of Tankyrases.. ACS Med Chem Lett, 4 (12): (1173-1177). [PMID:24900625]
13. Sun Z, Khan J, Makowska-Grzyska M, Zhang M, Cho JH, Suebsuwong C, Vo P, Gollapalli DR, Kim Y, Joachimiak A, Hedstrom L, Cuny GD.. (2014) Synthesis, in vitro evaluation and cocrystal structure of 4-oxo-[1]benzopyrano[4,3-c]pyrazole Cryptosporidium parvum inosine 5'-monophosphate dehydrogenase (CpIMPDH) inhibitors.. J Med Chem, 57 (24): (10544-10550). [PMID:25474504]
14. Klaeger S, Heinzlmeir S and Wilhelm M et al. (2017) The target landscape of clinical kinase drugs.. Science, 358 (6367): (). [PMID:29191878]
15. Chacko S, Boshoff HIM, Singh V, Ferraris DM, Gollapalli DR, Zhang M, Lawson AP, Pepi MJ, Joachimiak A, Rizzi M, Mizrahi V, Cuny GD, Hedstrom L.. (2018) Expanding Benzoxazole-Based Inosine 5'-Monophosphate Dehydrogenase (IMPDH) Inhibitor Structure-Activity As Potential Antituberculosis Agents.. J Med Chem, 61 (11): (4739-4756). [PMID:29746130]
16. Shah CP, Kharkar PS.. (2018) Discovery of novel human inosine 5'-monophosphate dehydrogenase 2 (hIMPDH2) inhibitors as potential anticancer agents.. Eur J Med Chem, 158 (): (286-301). [PMID:30223117]
17. Long MJC, Lawson AP, Baggio R, Qian Y, Rozhansky L, Fasci D, El Oualid F, Weerapana E, Hedstrom L.. (2019) Diarylcarbonates are a new class of deubiquitinating enzyme inhibitor.. Bioorg Med Chem Lett, 29 (2): (204-211). [PMID:30528168]
18. Natsumeda, Y Y and 5 more authors.. (1990) Two distinct cDNAs for human IMP dehydrogenase.. The Journal of biological chemistry, (25): (). [PMID:1969416]
19. Collart, F R FR and Huberman, E E.. (1988) Cloning and sequence analysis of the human and Chinese hamster inosine-5'-monophosphate dehydrogenase cDNAs.. The Journal of biological chemistry, (25): (). [PMID:2902093]
20. Hager, P W PW, Collart, F R FR, Huberman, E E and Mitchell, B S BS.. (1995) Recombinant human inosine monophosphate dehydrogenase type I and type II proteins. Purification and characterization of inhibitor binding.. Biochemical pharmacology, (11): (). [PMID:7763314]
21. Zimmermann, A G AG, Spychala, J J and Mitchell, B S BS.. (1995) Characterization of the human inosine-5'-monophosphate dehydrogenase type II gene.. The Journal of biological chemistry, (24): (). [PMID:7896827]
22. Carr, S F SF, Papp, E E, Wu, J C JC and Natsumeda, Y Y.. (1993) Characterization of human type I and type II IMP dehydrogenases.. The Journal of biological chemistry, (25): (). [PMID:7903306]
23. Glesne, D A DA and Huberman, E E.. (1994) Cloning and sequence of the human type II IMP dehydrogenase gene.. Biochemical and biophysical research communications, (30): (). [PMID:7999076]
24. Glesne, D D, Collart, F F, Varkony, T T, Drabkin, H H and Huberman, E E.. (1993) Chromosomal localization and structure of the human type II IMP dehydrogenase gene (IMPDH2).. Genomics, (): (). [PMID:8098009]
25. Colby, T D TD, Vanderveen, K K, Strickler, M D MD, Markham, G D GD and Goldstein, B M BM.. (1999) Crystal structure of human type II inosine monophosphate dehydrogenase: implications for ligand binding and drug design.. Proceedings of the National Academy of Sciences of the United States of America, (30): (). [PMID:10097070]
26. Markland, W W, McQuaid, T J TJ, Jain, J J and Kwong, A D AD.. (2000) Broad-spectrum antiviral activity of the IMP dehydrogenase inhibitor VX-497: a comparison with ribavirin and demonstration of antiviral additivity with alpha interferon.. Antimicrobial agents and chemotherapy, (): (). [PMID:10722482]
27. Chen, X X, Ji, Z L ZL and Chen, Y Z YZ.. (2002) TTD: Therapeutic Target Database.. Nucleic acids research, (1): (). [PMID:11752352]
28. Andersen, Jens S JS and 5 more authors.. (2003) Proteomic characterization of the human centrosome by protein correlation profiling.. Nature, (4): (). [PMID:14654843]
29. McLean, Jeremy E JE and 5 more authors.. (2004) Inosine 5'-monophosphate dehydrogenase binds nucleic acids in vitro and in vivo.. The Biochemical journal, (15): (). [PMID:14766016]
30. Rush, John J and 9 more authors.. (2005) Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.. Nature biotechnology, (): (). [PMID:15592455]
31. Vannozzi, F F and 9 more authors.. (2004) An exploratory study on pharmacogenetics of inosine-monophosphate dehydrogenase II in peripheral mononuclear cells from liver-transplant recipients.. Transplantation proceedings, (): (). [PMID:15621150]
32. and Allison, A C AC.. (2005) Mechanisms of action of mycophenolate mofetil.. Lupus, (): (). [PMID:15803924]
33. Bremer, Sara S, Rootwelt, Helge H and Bergan, Stein S.. (2007) Real-time PCR determination of IMPDH1 and IMPDH2 expression in blood cells.. Clinical chemistry, (): (). [PMID:17463174]
34. Wang, Jian J and 7 more authors.. (2007) A novel variant L263F in human inosine 5'-monophosphate dehydrogenase 2 is associated with diminished enzyme activity.. Pharmacogenetics and genomics, (): (). [PMID:17496727]
35. Sahasranaman, Srikumar S, Howard, Danny D and Roy, Sandip S.. (2008) Clinical pharmacology and pharmacogenetics of thiopurines.. European journal of clinical pharmacology, (): (). [PMID:18506437]
36. Dephoure, Noah N and 6 more authors.. (2008) A quantitative atlas of mitotic phosphorylation.. Proceedings of the National Academy of Sciences of the United States of America, (5): (). [PMID:18669648]
37. Zhou, Houjiang H and 6 more authors.. (2013) Toward a comprehensive characterization of a human cancer cell phosphoproteome.. Journal of proteome research, (4): (). [PMID:23186163]
38. Calise, S John SJ and 5 more authors.. (2014) Glutamine deprivation initiates reversible assembly of mammalian rods and rings.. Cellular and molecular life sciences : CMLS, (): (). [PMID:24477477]
39. Lin, Ran R and 8 more authors.. (2017) CLOCK Acetylates ASS1 to Drive Circadian Rhythm of Ureagenesis.. Molecular cell, (5): (). [PMID:28985504]
40. Shah, Chetan P CP and Kharkar, Prashant S PS.. (2018) Newer human inosine 5'-monophosphate dehydrogenase 2 (hIMPDH2) inhibitors as potential anticancer agents.. Journal of enzyme inhibition and medicinal chemistry, (): (). [PMID:29792360]
41. Lee, Yejin Y and 11 more authors.. (2018) ANKRD9 is associated with tumor suppression as a substrate receptor subunit of ubiquitin ligase.. Biochimica et biophysica acta. Molecular basis of disease, (): (). [PMID:30293565]

Recombinant IMPDH2 Antibody

库存信息

库存信息

库存信息

库存信息

基本信息

产品属性

应用

质检证书(COA)

质检报告(COA)

图片

相关文档

质检报告COA

相关技术文章

产品问答

产品问答

参考文献