去氧胆酸, 细胞膜破坏剂

货号 (SKU)	包装规格	是否现货
D103697-5g	5g	现货
D103697-25g	25g	现货
D103697-100g	100g	现货
D103697-500g	500g	现货
D103697-2.5kg	2.5kg	现货

基本描述

别名	脱氧胆酸,络胆酸\|脱氧胆酸\|3α,12α-二羟-5β-胆烷酸\|络胆酸\|3α,12α-二羟基-5β-胆汁酸\|7-脱氧胆酸
英文别名	DEOXYCHOLIC ACID\|83-44-3\|deoxycholate\|Desoxycholic acid\|Cholerebic\|Cholorebic\|Choleic acid\|Degalol\|Deoxycholatic acid\|Droxolan\|Pyrochol\|Septochol\|Desoxycholsaeure\|7alpha-Deoxycholic acid\|3alpha,12alpha-Dihydroxy-5beta-cholanic acid\|Cholic acid, deoxy-\|Dih
规格或纯度	98%
英文名称	Deoxycholic acid
运输条件	常规运输
产品介绍	产品介绍：无臭，味苦。不为毛地黄皂苷（Digitonin)所沉淀。微溶于水，溶于乙醇、醚、三氧甲烷、丙酮、冰乙酸，在15℃时的溶解度（g/L)：水中0.24、乙醇220.7、乙醚1.16、氯仿2.94、苯0.12、丙酮10.46、冰乙醇9.06。溶于氢氧化碱和碳酸碱溶液。半数致死量（小鼠，腹腔）130mg/kg。有刺激性。脱氧胆酸是一种促炎剂。产品应用：脱氧胆酸已被用于评估在癌性环境下，脱氧胆酸和叶酸共改性壳聚糖胶束的 pH 响应机制。它还被用于研究熊去氧胆酸在实验性结肠炎中的剂量依赖性抗炎作用。 Deoxycholic acid has been used in a study to assess a pH-Responsive Mechanism of a Deoxycholic Acid and Folate Co-Modified Chitosan Micelle under Cancerous Environment. It has also been used in a study to investigate dose-dependent anti-inflammatory effect of ursodeoxycholic acid in experimental colitis.

产品属性

ALogP	4.9

名称和标识符

EC号	201-478-5
IUPAC Name	(4R)-4-[(3R,5R,8R,9S,10S,12S,13R,14S,17R)-3,12-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid
INCHI	InChI=1S/C24H40O4/c1-14(4-9-22(27)28)18-7-8-19-17-6-5-15-12-16(25)10-11-23(15,2)20(17)13-21(26)24(18,19)3/h14-21,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15-,16-,17+,18-,19+,20+,21+,23+,24-/m1/s1
InChi Key	KXGVEGMKQFWNSR-LLQZFEROSA-N
Canonical SMILES	CC(CCC(=O)O)C1CCC2C1(C(CC3C2CCC4C3(CCC(C4)O)C)O)C
Isomeric SMILES	C[C@H](CCC(=O)O)[C@H]1CC[C@@H]2[C@@]1([C@H](C[C@H]3[C@H]2CC[C@H]4[C@@]3(CC[C@H](C4)O)C)O)C
WGK Germany	3
RTECS	FZ2100000
PubChem CID	222528
分子量	392.58
Beilstein号	3219882

数据库链接

PubChem CID	222528
ChEMBL Ligand	CHEMBL406393
Wikipedia	Deoxycholic_acid
ChEBI	CHEBI:28834
CAS Registry No.	83-44-3
RCSB PDB Ligand	DXC
DrugCentral Ligand	4988
GPCRdb Ligand	deoxycholic acid

化学和物理性质

溶解性	The free acid is soluble at 0.044 g/L in water at 20°C. Solubility in methanol is almost transparent.
密度	1.128
敏感性	对湿度敏感

安全和危险性（GHS）

象形图	Harmful
信号词	Warning
危险声明	H315: Causes skin irritation H319: Causes serious eye irritation H335: May cause respiratory irritation H302: Harmful if swallowed
预防措施声明	P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P270,P304+P340,P403+P233,P362+P364,P330,P264+P265,P301+P317,P337+P317,P332+P317,P319
WGK Germany	3
RTECS	FZ2100000
个人防护装备	dust mask type N95 (US),Eyeshields,Gloves

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参考文献

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