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D-赤型-鞘氨醇-1-磷酸酯(C20碱)

规格或纯度: >99%

CAS编号: 799812-75-2
分子式: C₂₀H₄₂NO₅P
分子量: 407.52
PubChem编号: 46891771

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货号 (SKU)	包装规格	是否现货	价格	数量
D130702-1mg	1mg	现货

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S1P2 receptor Agonist

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基本描述

英文别名	799812-75-2\|[(E,2S,3R)-2-azaniumyl-3-hydroxyicos-4-enyl] hydrogen phosphate\|S1P d20:1\|(2S,3R,4E)-2-Azaniumyl-3-hydroxyicos-4-en-1-yl hydrogen phosphate\|D-erythro-Sphingosine-C20-1-phosphate\|Sphingosine-1-Phosphate (d20:1)\|GTPL11496\|DTXSID50677069\|S1P (d20
规格或纯度	>99%
英文名称	D-erythro-sphingosine-1-phosphate (C20 base)
储存温度	-20°C储存
运输条件	超低温冰袋运输
产品介绍	product description： Sphingosine-1-phosphate (S1P) is a zwitterionic sphingolipid. It is found in insects, yeasts and plants. Sphingosine-1-Phosphate (d20:1) is a phosphorylated derivative of long chain base C20 sphingosine. application： Sphingosine-1-phosphate (S1P)-d7 has been used as a reference standard in liquid chromatography/tandem mass spectrometry analysis for quantitative analyses of S1P d20:1 in central nervous system of healthy mice and in human glioblastoma tissue. Biochemical mechanism: Sphingosine-1-phosphate (S1P) is an important cellular metabolite and signaling lipid in animal cells. It aids in various physiological and cellular processes such as atherosclerosis, inflammation, immunity, tumorigenesis, and cell proliferation. S1P plays a vital role in mammalian brain and cardiac development. S1P d20:1 serves as a partial agonist at the S1P receptor 2 (S1P2). It has an ability to inhibit S1P d18:1‐mediated cyclooxygenase 2(COX2) induction.

名称和标识符

IUPAC Name	[(E,2S,3R)-2-azaniumyl-3-hydroxyicos-4-enyl] hydrogen phosphate
INCHI	InChI=1S/C20H42NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-20(22)19(21)18-26-27(23,24)25/h16-17,19-20,22H,2-15,18,21H2,1H3,(H2,23,24,25)/b17-16+/t19-,20+/m0/s1
InChi Key	YUUWWSOTAGQJFW-YIVRLKKSSA-N
Canonical SMILES	CCCCCCCCCCCCCCCC=CC(C(COP(=O)(O)[O-])[NH3+])O
Isomeric SMILES	CCCCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)[O-])[NH3+])O
PubChem CID	46891771
分子量	407.52

数据库链接

PubChem CID	46891771
CAS Registry No.	799812-75-2
GPCRdb Ligand	S1P d20:1

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参考文献

1. Vutukuri R, Koch A, Trautmann S, Schreiber Y, Thomas D, Mayser F, Meyer Zu Heringdorf D, Pfeilschifter J, Pfeilschifter W, Brunkhorst R. (2020) S1P d20:1, an endogenous modulator of S1P d18:1/S1P₂ -dependent signaling.. FASEB J, 34 (3): (3932-3942). [PMID:31944406]

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