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水合胆酸钠

规格或纯度: for cell culture,≥99.0%
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货号 (SKU) 包装规格 是否现货 价格 数量
S104206-25g
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S104206-100g
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去垢剂 胆酸盐
main product photo

基本描述

别名 胆酸钠 水合物 | 3α,7α,12α-三羟基-5β-胆甾烷-24-羧酸 钠盐 | 胆酸钠盐
英文别名 2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoate hydrate
规格或纯度 for cell culture,≥99.0%
英文名称 Sodium cholate hydrate
生化机理 12-α羟化酶活性的下降会导致肝脏疾病患者中胆酸水平降低。
应用 非变性去垢剂用于抽提膜蛋白。 已有研究关于采用水合胆酸钠研究磷脂配方和表面活性剂对弹性脂质体亲水性药物真皮给药的影响。 它也被用于一项研究用于经皮给药的弹性变形囊泡，转移体研究。
储存温度 充氩
运输条件 常规运输
产品介绍

胆酸盐是由肝脏中的胆固醇产生的初级胆汁酸。它是在固醇12α-羟化酶（CYP8B1）存在的情况下由胆固醇合成的一种阴离子洗涤剂。水合胆酸钠是一种生物表面活性剂，可作为水溶液中的还原剂。非变性去垢剂用于抽提膜蛋白。 已有研究关于采用水合胆酸钠研究磷脂配方和表面活性剂对弹性脂质体亲水性药物真皮给药的影响。 它也被用于一项研究用于经皮给药的弹性变形囊泡，转移体研究。 

用途：
胆酸盐是肝脏在胆固醇分解过程中产生的一种胆酸。胆酸盐向下调节胆固醇-7α-羟化酶（胆汁酸合成中的限速步骤）。 胆酸盐是一种阴离子洗涤剂，可单独使用或与尿素一起使用，用于提取和重建膜蛋白和蛋白复合物。
胆酸钠水合物已被用于：
作为胆汁酸用于诱导胆汁酸响应（BEAR）转录系统,
作为弯曲杆菌确定成分肉汤（CDB）的成分用于测试其对空肠弯曲杆菌i{52应激反应的影响
测试其对胆汁酸传感器的敏感性；

Cholate is a primary bile acid produced from cholesterol in the liver. It is an anionic detergent synthesized from cholesterol in the presence of sterol 12α-hydroxylase (CYP8B1). 

Application：

Cholate is a bile acid produced in liver during cholesterol breakdown. Cholate downregulates cholesterol-7-α-hydroxylase (rate-limiting step in bile acid synthesis). Cholate, an anionic detergent, is used alone and in combination with urea to extract and reconstitute membrane proteins and protein complexes.
Sodium cholate hydrate has been used:
as a bile acid to induce bile acid-responsive (BEAR) transcription system,
as a component of Campylobacter defined broth (CDB) to test its effect on stress response in Campylobacter jejuni{52
to test its sensitivity towards the bile acid sensor;

名称和标识符

EC号 MFCD00150749
IUPAC Name sodium;(4R)-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-trihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoate;hydrate
INCHI InChI=1S/C24H40O5.Na.H2O/c1-13(4-7-21(28)29)16-5-6-17-22-18(12-20(27)24(16,17)3)23(2)9-8-15(25)10-14(23)11-19(22)26;;/h13-20,22,25-27H,4-12H2,1-3H3,(H,28,29);;1H2/q;+1;/p-1/t13-,14+,15-,16-,17+,18+,19-,20+,22+,23+,24-;;/m1../s1
InChi Key MUVVIYFKOVLQHL-RCVKHMDESA-M
Canonical SMILES O.[Na+].C[C@H](CCC([O-])=O)C1CCC2C3[C@H](O)CC4C[C@H](O)CC[C@]4(C)C3C[C@H](O)[C@]12C
Isomeric SMILES C[C@H](CCC(=O)[O-])[C@H]1CC[C@@H]2[C@@]1([C@H](C[C@H]3[C@H]2[C@@H](C[C@H]4[C@@]3(CC[C@H](C4)O)C)O)O)C.O.[Na+]
WGK Germany 3
PubChem CID 23679061
分子量 430.55 (anhydrous basis)
Beilstein号 3582354

化学和物理性质

溶解性 Soluble in water.
敏感性 对湿度敏感

安全和危险性（GHS）

WGK Germany 3
个人防护装备 Eyeshields， Gloves， type N95 (US)， type P1 (EN143) respirator filter

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参考文献

1. P Fafournoux,E E Dudenhausen,M S Kilberg.  (1989-03-25)  Solubilization and reconstitution characteristics of hepatic system A-mediated amino acid transport..  The Journal of biological chemistry,  264  ((9)):  (4805-4811).  [PMID:2925669]
2. Mahendra Singh,Lauren Cowell,Sachiko Seo', "Geraldine O'Neill", 'Erica Golemis.  (2007-08-19)  Molecular basis for HEF1/NEDD9/Cas-L action as a multifunctional co-ordinator of invasion, apoptosis and cell cycle..  Cell biochemistry and biophysics,  48  ((1)):  (54-72).  [PMID:17703068]
3. Cynthia L Morris-Kukoski,Madeline A Montgomery,Rena L Hammer.  (2014-08-08)  Analysis of extensively washed hair from cocaine users and drug chemists to establish new reporting criteria..  Journal of analytical toxicology,  38  ((9)):  (628-636).  [PMID:25100648]
4. Yuri Kashima,Satoshi Kanematsu,Saori Asai,Mio Kusada,Suzuyo Watanabe,Takuji Kawashima,Tadashi Nakamura,Masaya Shimada,Tsuyoshi Goto,Satoshi Nagaoka.  (2014-08-22)  Identification of a novel hypocholesterolemic protein, major royal jelly protein 1, derived from royal jelly..  PloS one,  9  ((8)):  (e105073-e105073).  [PMID:25144734]
5. Paola Mura,Marco Bragagni,Natascia Mennini,Marzia Cirri,Francesca Maestrelli.  (2014-09-10)  Development of liposomal and microemulsion formulations for transdermal delivery of clonazepam: effect of randomly methylated β-cyclodextrin..  International journal of pharmaceutics,  475  ((1-2)):  (306-314).  [PMID:25194352]
6. Jilite Wang,Masaya Shimada,Yukina Kato,Mio Kusada,Satoshi Nagaoka.  (2014-11-07)  Cholesterol-lowering effect of rice bran protein containing bile acid-binding proteins..  Bioscience, biotechnology, and biochemistry,  79  ((3)):  (456-461).  [PMID:25374002]
7. Mayu Kakehi,Yoshinori Ikenaka,Shouta M M Nakayama,Yusuke K Kawai,Kensuke P Watanabe,Hazuki Mizukawa,Kei Nomiyama,Shinsuke Tanabe,Mayumi Ishizuka.  (2015-07-17)  Uridine Diphosphate-Glucuronosyltransferase (UGT) Xenobiotic Metabolizing Activity and Genetic Evolution in Pinniped Species..  Toxicological sciences : an official journal of the Society of Toxicology,  147  ((2)):  (360-369).  [PMID:26179383]
8. Wycliffe O Masanta,Andreas E Zautner,Raimond Lugert,Wolfgang Bohne,Uwe Gross,Andreas Leha,Mohammed Dakna,Christof Lenz.  (2018-09-25)  Proteome Profiling by Label-Free Mass Spectrometry Reveals Differentiated Response of Campylobacter jejuni 81-176 to Sublethal Concentrations of Bile Acids..  Proteomics. Clinical applications,  13  ((3)):  (e1800083-e1800083).  [PMID:30246935]
9. Wen C Aw,Samuel G Towarnicki,Richard G Melvin,Neil A Youngson,Michael R Garvin,Yifang Hu,Shaun Nielsen,Torsten Thomas,Russell Pickford,Sonia Bustamante,Antón Vila-Sanjurjo,Gordon K Smyth,J William O Ballard.  (2018-11-07)  Genotype to phenotype: Diet-by-mitochondrial DNA haplotype interactions drive metabolic flexibility and organismal fitness..  PLoS genetics,  14  ((11)):  (e1007735-e1007735).  [PMID:30399141]
10. Peng Bai,Ying Liu,Shuai Xue,Ghislaine Charpin-El Hamri,Pratik Saxena,Haifeng Ye,Mingqi Xie,Martin Fussenegger.  (2019-07-10)  A fully human transgene switch to regulate therapeutic protein production by cooling sensation..  Nature medicine,  25  ((8)):  (1266-1273).  [PMID:31285633]
11. A Ambesi,E L VanAlstyne,E E Bagwell,G E Lindenmayer.  (1991-11-01)  Sequential use of detergents for solubilization and reconstitution of a membrane ion transporter..  Analytical biochemistry,  198  ((2)):  (312-317).  [PMID:1799216]
12. John Y L Chiang.  (2009-04-07)  Bile acids: regulation of synthesis..  Journal of lipid research,  50  ((10)):  (1955-1966).  [PMID:19346330]
13. Katrin Rössger,Ghislaine Charpin-El-Hamri,Martin Fussenegger.  (2013-11-28)  Bile acid-controlled transgene expression in mammalian cells and mice..  Metabolic engineering,  21  ():  (81-90).  [PMID:24280297]
14. Timothy R Rebbeck.  (2016-12-18)  Prostate Cancer Genetics: Variation by Race, Ethnicity, and Geography..  Seminars in radiation oncology,  27  ((1)):  (3-10).  [PMID:27986209]
15. Albert Castellví,Isidro Crespo,Eva Crosas,Ana Cámara-Artigas,José A Gavira,Miguel A G Aranda,Xavier Parés,Jaume Farrés,Judith Juanhuix.  (2019-03-01)  Efficacy of aldose reductase inhibitors is affected by oxidative stress induced under X-ray irradiation..  Scientific reports,  9  ((1)):  (3177-3177).  [PMID:30816220]
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