CAS(19983-44-9),6-硝基苯并[b] 噻吩-1,1-二氧化物,Stattic|19983-44-9|6-Nitrobenzo[b]thiophene 1,1-dioxide|6-nitro-1-benzothiophene 1,1-dioxide|1,1-DIOXIDE-6-NITRO-BENZO[B]THIOPHENE|STAT3 Inhibitor V, Stattic|6-Nitrobenzo[b]thiophene-1,1-dioxide|Benzo,Stattic-阿拉丁试剂

货号 (SKU)	包装规格	是否现货
S129623-25mg	25mg	现货
S129623-100mg	100mg	现货
S129623-250mg	250mg	现货
S129623-1g	1g	期货

基本描述

英文别名	Stattic\|19983-44-9\|6-Nitrobenzo[b]thiophene 1,1-dioxide\|6-nitro-1-benzothiophene 1,1-dioxide\|1,1-DIOXIDE-6-NITRO-BENZO[B]THIOPHENE\|STAT3 Inhibitor V, Stattic\|6-Nitrobenzo[b]thiophene-1,1-dioxide\|Benzo[b]thiophene, 6-nitro-, 1,1-dioxide\|CHEMBL1337170\|MFCD0
规格或纯度	≥98%
英文名称	Stattic
生化机理	Stat3 Inhibitor V, Stattic is a small molecule shown to selectively inhibit the activation of the Stat3 transcription factor by blocking phosphorylation and dimerization events. Stattic has been used as a tool for probing the upstream activation of this factor, significantly expressed in many cancer cell lines, and interruption of this pathway in breast cancer cell lines lead to an increased apoptotic rate in these cells. Stat3 Inhibitor V, Stattic is an inhibitor of Stat3.Selective STAT3 inhibitor. Inhibits activation, dimerization and nuclear translocation of STAT3 by interacting with the SH2 domain. Displays selectivity over STAT1, STAT5, c-Myc/Max, Jun/Jun and Lck. Induces apoptosis in vitro and in vivo .
应用	An inhibitor of Stat3 activation
储存温度	-20°C储存
运输条件	超低温冰袋运输
备注	如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
产品介绍	Stattic是STAT3的有效抑制剂，主要用于癌症的治疗。An inhibitor of Stat3 activation 应用：Stattic 是一种有效的 STAT3 抑制剂，可以抑制 STAT3 磷酸化 (磷酸化位点为 Y705 和 S727)。Stattic 抑制高亲和力磷酸肽与 STAT3 的 SH2 域结合。Stattic 可改善 Alport 综合征 (AS) 小鼠的肾功能不全。 Stattic is a potent inhibitor of STAT3, used for cancer treatment. An inhibitor of Stat3 activation

名称和标识符

IUPAC Name	6-nitro-1-benzothiophene 1,1-dioxide
INCHI	InChI=1S/C8H5NO4S/c10-9(11)7-2-1-6-3-4-14(12,13)8(6)5-7/h1-5H
InChi Key	ZRRGOUHITGRLBA-UHFFFAOYSA-N
Canonical SMILES	C1=CC(=CC2=C1C=CS2(=O)=O)[N+](=O)[O-]
Isomeric SMILES	C1=CC(=CC2=C1C=CS2(=O)=O)[N+](=O)[O-]
WGK Germany	3
PubChem CID	2779853
分子量	211.19

化学和物理性质

溶解性	DMSO 42 mg/mL Water <1 mg/mL Ethanol <1 mg/mL
密度	1.6
折光率	1.67
沸点	461.1° C
熔点	186 - 188 °C

安全和危险性（GHS）

象形图	Harmful
信号词	Warning
危险声明	H315: Causes skin irritation H319: Causes serious eye irritation H335: May cause respiratory irritation H302: Harmful if swallowed
预防措施声明	P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P270,P304+P340,P403+P233,P362+P364,P330,P264+P265,P301+P317,P337+P317,P332+P317,P319
WGK Germany	3
个人防护装备	dust mask type N95 (US), Eyeshields, Gloves

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参考文献

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6-硝基苯并[b] 噻吩-1,1-二氧化物

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库存信息

库存信息

库存信息

基本描述

名称和标识符

化学和物理性质

安全和危险性（GHS）

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