Anti-MRSA agent 12 (Compound SM-5) is an antibiotic , which exhibits antibacterial activity against Staphylococcus aureus , S. epidermidis and Escherichia coli with MIC of 7.81, 7.81 and 62.5 μM. Anti-MRSA agent 12 inhibits the methicillin-resistant S. aureus ( MRSA ) through inhibition of biofilm formation.