Alternariol-d 2 is deuterium labeled Alternariol. Alternariol is an orally ingested mycotoxin produced by Alternaria , capable of inhibiting the activity of topoisomerase I and II ( topoisomerase I , topoisomerase II ). Alternariol has weak estrogenic ( Estrogen Receptor/ERR ) and androgen/antiandrogen ( Androgen Receptor ) effects. Alternariol can induce apoptosis , trigger cell cycle arrest, suppress innate immune responses, and exhibit anti-tumor activity. Alternariol has genotoxic, mutagenic, and endocrine-disrupting effects.