Antibacterial agent 105 (Compound 17) is a phenanthrolinic analog of quinolones show antibacterial activity against M. tuberculosis with antibacterial activity (MIC 90 =2.64 μM)。 Antibacterial agent 105 exhibits antibacterial activities against different bacterial species with MIC 90 s of 11.18, 11.18,0.70,1.40,44.70, and 22.35 μM for M. smegmatis , M. aurum , M. marinum , BCG , E. aerogenes and S. aureus , respectively.