Anagrelide - 13 C 2 , 15 N,d 2 is 15 N and deuterated labeled Anagrelide. Anagrelide is a potent inhibitor of phosphodiesterase type III ( PDE3 ) ( IC 50 =36 nM). Anagrelide , an imidazoquinazoline derivative, acts as an inhibitor of platelet aggregation. Anagrelide inhibits bone marrow megakaryocytopoiesis. Anagrelide decreases gastrointestinal stromal tumor (GIST) cell proliferation and promotes their apoptosis in vitro. Anagrelide is a platelet-lowering agent and plays in the antithrombopoietic action.