Anticancer agent 157 (compound 15) is a NO inhibitor ( IC 50 =0.62 μg/mL) with anti-inflammatory and anticancer activities. Anticancer agent 157 can bind to iNOS (inducible NO synthase ) and caspase 8 , causing nuclear fragmentation and chromatin condensation, inducing apoptosis. Anticancer agent 157 inhibits HT29 colon cancer cells ( IC 50 =2.45 μg/mL), Hep-G2 liver cancer cells ( IC 50 =3.25 μg/mL), and B16-F10 murine melanoma cells ( IC 50 =3.84 μg/mL).