Antimalarial agent 9 (Compound 11) is a potent antimalarial agent. Antimalarial agent 9 is a quinoline-imidazole derivative compound. Antimalarial agent 9 exhibits significant antimalarial efficacy in-vitro against both CQ-sensitive ( IC 50 -0.14 μM) and MDR strain ( IC 50 -0.41 μM) with minimal cytotoxicity and high selectivity.