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Antiviral agent 64 (Compound 12) is a diarylheptanoid that can be isolated from Alpinia officinarum. Antiviral agent 64 exhibits cytotoxicity in human neuroblastoma cell IMR-32 with an IC 50 of 0.23 μM. Antiviral agent 64 exhibits antiviral efficacy, that inhibits RSV , poliovirus , measles virus , HSV-1 , and influenza virus H1N1 , with EC 50 of 13.3, 3.7, 6.3, 5.7, and <10 μg/mL, respectively.