AAK1/HDACs-IN-1 (Compound 12) is the dual inhibitor for AAK1 and HDAC , that inhibits AAK1 , HDAC1 , and HDAC6 with IC 50 s of 15.9, 148.6, and 5.2 nM, respectively. AAK1/HDACs-IN-1 inhibits SARS-CoV-2 infection , suppresses the endocytosis of ACE2-SARS-CoV-2 complex, as well as AP2M1-ACE2 interaction.