Antiproliferative agent-64 (Compound 76) is an inhibitor for eukaryotic translation initiation factor 4E ( eIF4E ), that block the secondary structure of mRNA , thereby inhibiting protein translation. Antiproliferative agent-64 inhibits the 5' untranslated region (5'UTR) of c-Myc ( c-myc 5'UTR) with an EC 50 of 1.2 nM, inhibits 5'UTR encoding tubulin (tub 5'UTR) with an EC 50 of 40 nM. Antiproliferative agent-64 inhibits the proliferation of MDA-MB-231 with an EC 50 of 7 nM.