Anticancer agent 98 (compound 12k) is a microtubule/tubulin -polymerization inhibitor (K d =16.9 μM). Anticancer agent 98 exerts antiproliferative potency against tumor cells, exhibits anti-angiogenesis effect in vitro. Anticancer agent 98 exhibits good human and mouse liver microsomes stability with both t 1/2 >300 min.