计算溶液所需的质量、体积或浓度。
Antitumor agent-169 (Compound B3) is a dual inhibitor PD-1/PD-L1 interaction and PARP7 , with IC 50 s of 0.426 μM and 2.50 nM. Antitumor agent-169 exhibits an affinity to human PD-L1 , with K i of 20.2 nM. Antitumor agent-169 restores the T cell function, increases IFN-γ secretion. Antitumor agent-169 inhibits cell viability of MDA-MB-231 and Jurkat T, exhibits antitumor efficacy against melanoma in mouse model and good pharmacokinetic characteristics.