AZ0108 is an inhibitor for poly ADP-ribose polymerase ( PARP ), which inhibits PARP1 , PARP2 , PARP3 , PARP6, TNKS1, TNKS2, with IC 50 s of <0.03, <0.03, 2.8, 0.083, 3.2, >3 μM, respectively. AZ0108 prevents centrosome clustering with an EC 50 of 0.053 μM, and exhibits cytotoxicity in cell OCI-LY-19 with GI 50 of 0.017 μM. AZ0108 exhibits good in vivo pharmacokinetic characters in rat/mouse models.