A3AR agonist 2 (Compound 19) a selective A3AR agonist ( K i : 22.1 nM). A3AR agonist 2 stimulates β-arrestin2 recruitment, with EC 50 value of 4.36 nM. A3AR agonist 2 can be used for research of inflammatory diseases, ischemia, cancer , neuropathic pain, liver diseases, and other chronic conditions. A3AR agonist 2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.