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Aloenin aglycone (compound 13) is an NF-κB inhibitor that can be isolated from aloe exudate. Aloenin aglycone inhibits TNFα-induced NF-κB transcriptional activity ( IC 50 : 18.7 μM). Aloenin aglycone (10 μM) also reduced inducible nitric oxide synthase ( iNOS ) and intercellular adhesion molecule 1 (ICAM-1) gene expression after treatment of HepG2 cells with 10 ng/mL TNFα.