ATX inhibitor 12 (compound 20) is an orally active and potent ATX ( autotaxin ) inhibitor, with an IC 50 of 1.72 nM. ATX inhibitor 12 effectively alleviates lung structural damage with fewer fibrotic lesions at an oral dose of 60 mg/kg in C57Bl/6J mice. ATX inhibitor 12 can be uesd for idiopathic pulmonary fibrosis (IPF) research.