AChE-IN-63 (Compound 5AD) is a selective inhibitor of hAChE ( IC 50 =0.103 μM). AChE-IN-63 also inhibits hBChE and hBACE-1 ( IC 50 = 10 μM (hBChE); 1.342 μM (hBACE-1)). AChE-IN-63 inhibits Aβ aggregation, preventing the formation and deposition of Aβ1-42. AChE-IN-63 can effectively penetrate the blood-brain barrier and is orally effective. It is primarily used in Alzheimer's disease research.