AChE-IN-11 (compound 5C) is a triple inhibitor targeting AChE/MAO-B/BACE1 ( IC 50 =7.9 μM, 9.9 μM, 8.3 μM,respectively) and a selective metal ion chelators. AChE-IN-11 exhibits mixed AChE inhibitory effects, binding to both CAS and PAS of AChE. AChE-IN-11 also exhibits good antioxidant activity (ORAC=2.5 eq) and potential neuroprotective effects in Alzheimer's disease.