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,适用于对基线干扰要求严格的色谱和分析工作流程。
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在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
AChE/BuChE-IN-1 (Compound 1), a chrysin derivative, is a selective butyrylcholinesterase (BuChE) inhibitor with an IC 50 of 0.48 μM. AChE/BuChE-IN-1 inhibits acetylcholinesterase ( AChE ) with an IC 50 of 7.16 μM. AChE/BuChE-IN-1 shows strong scavenging ·OH activities with a IC 50 of 0.1674 μM. AChE/BuChE-IN-1 inhibits reactive oxygen species (ROS), Aβ 1-42 aggregation (self-, Cu 2+ -induced, AChE-induced). AChE/BuChE-IN-1 has high BBB permeability and bioavailability and low cell toxicity. AChE/BuChE-IN-1 has the potential for Alzheimer' disease (AD) research.