计算溶液所需的质量、体积或浓度。
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概述
Artesunate is a derivative of artemisinin and belongs to a class with antimicrobial properties. The compound is an active ingredient in the Chinese herb Artemisia annua and has been used in Malaria studies. Artesunate has been tested against 55 cell lines and demonstrated anti-cancer activity. Research shows that conditional expression of CDC25A heightens the sensitivity of tumor cells to artesunate.青蒿琥酯是一种半合成的青蒿素衍生物,它被证明有效抗寄生虫，如肝吸虫（liver flukes），也显示了对不同类型的肿瘤细胞株有细胞毒性作用。
Information
Artesunate (WR-256283) is a part of the artemisinin group of agents with an IC50 of < 5 μM for small cell lung carcinoma cell line H69. It is a potential inhibitor ofSTAT-3and exhibits selective cytotoxicity of cancer cells over normal cells in vitro; A p
In vitro
ART could alter the biomechanical properties of the glioma cells to inhibit cell proliferation, migration and invasion .The ART significantly suppresses the cell proliferation, induces the apoptosis and promoted cell cycle arrest at G0/G1 phase in SKM-1 cells. The mechanisms of ART anti-MDS is associated with the increase of intracellular calciumion concentration and ROS levels. In addition, the pro-apoptotic activity of ART may be involved in the regulation of BCL-2 /BAX ratio and the expressions of P-bad and survivin. ART treatment demethylates CDH1, which, in turn recovers the E-cadherin activation in SKM-1 cells.
In vivo
Artesunate is a medication used to treat malaria. Artesunate can induce radiosensitivity of HeLa cells in vivo using Xenograft model of nude mice. Artesunate had a relatively high immunosuppressive activity with low toxicity, and could inhibit T lymphocyte proliferation induced by mitogen and alloantigen.
Cell Data
cell lines：
Concentrations：0, 12.5, 25, 50 µg/mL
Incubation Time：0, 24, 48, and 72 h
Powder Purity:≥97%
规格
英文别名
Butanedioic acid, 1-[(3R,5aS,6R,8aS,9R,10S,12R,12aR)-decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-yl] ester
规格或纯度
Moligand™, 10mM in DMSO
英文名称
Artesunate (WR-256283)
生化机理
青蒿琥酯（WR-256283）属于青蒿素类药物，对小细胞肺癌细胞株 H69 的 IC50 小于 5 μM。它是 STAT-3 的潜在抑制剂，在体外对癌细胞而非正常细胞具有选择性细胞毒性；是 EXP1 的强效抑制剂。
储存条件
-80℃储存
运输条件
特低温运输
名称和识别符
EC号
618-170-5
分子类型
小分子
Isomeric SMILES
C[C@@H]1CC[C@H]2[C@H]([C@@H](O[C@H]3[C@@]24[C@H]1CC[C@](O3)(OO4)C)OC(=O)CCC(=O)O)C
分子量
384.42
Reaxy-Rn
7496318
Reaxys-RN link address
https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=7496318&ln=
高级数据
产品属性
| ALogP | 2.5 |
|---|
化学和物理性质
溶解性
Solubility (25°C) In vitro DMSO: 12 mg/mL (38.42 mM); Water: Insoluble; Ethanol: Insoluble;
比旋光度
5.5° (C=1,CH2Cl2)
熔点
133°C
安全和危险性（GHS）
Merck Index
818
质检证书(CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
技术文档和文章
此产品的引用文献
溶液计算器
产品仅提供给经过验证的企业、机构和合格的专业人员用于研发。不适用于人类、动物、诊断或治疗。
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