计算溶液所需的质量、体积或浓度。
概述
Adrenalone HCl是一种肾上腺素激动剂，作为外用的血管收缩剂和止血剂，主要作用于α-1肾上腺素受体。
Information
Adrenalone is an adrenergic agonist used as a topical vasoconstrictor and hemostatic, mainly acts on alpha-1 adrenergic receptors.
In vitro
Adrenalone (12 μM) inhibits conversion of dopamine to norepinephrine by inhibiting dopamine β oxidase. The structure of Adrenalone differs from epinine only in that the former possesses a ketone group in the β position. The reduction of adrenalone (0.1 mM) by hydrated electrons in nitrogenated aqueous solutions containing either 10 or 100 mM tert-butyl alcohol results in identical transient spectra, therefore all OH radicals have been scavenged. While adrenalone behaves like a carbonyl compound during reduction, oxidation reactions are primarily governed by the catechol functional group. Adrenalone, which is a topical nasal decongestant, hemostatic, and vasoconstrictor, is a keton form of the natural substrate epinephrine. Adrenalone contains an aromatic ring that forms hydrophobic interactions with Phe72, Tyr152, and Phe317, an amine group that forms an ionic bond with Asp75, and a hydroxyl group that forms a hydrogen bond with Ala145. Adrenalone at 10 μM (100 μM) reduces substrate uptake to 99% (27%).
In vivo
Adrenalone (0.05%) administrated topically to the eyes of rabbits at 30 min intervals results in concentration of 7.75 mg/kg, 0.87 mg/kg and 2.51 mg/kg in cornea, aqueous humor and iris-ciliary body, respectively.
Cell Data
cell lines：
Concentrations：
Incubation Time：
Powder Purity:≥99%
规格
英文别名
Ethanone, 1-(3,4-dihydroxyphenyl)-2-(methylamino)-, hydrochloride (1:1)
规格或纯度
10mM in DMSO
英文名称
Adrenalone HCl
生化机理
肾上腺酮是一种肾上腺素能激动剂，可用作局部血管收缩剂和止血剂，主要作用于α-1肾上腺素能受体。
储存条件
-80℃储存
运输条件
特低温运输
名称和识别符
EC号
200-525-7
分子类型
小分子
Isomeric SMILES
CNCC(=O)C1=CC(=C(C=C1)O)O.Cl
分子量
217.65(as Anhydrous)
Beilstein号
3916102
Reaxy-Rn
3706932
Reaxys-RN link address
https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=3706932&ln=
高级数据
化学和物理性质
溶解性
Solubility (25°C) In vitro DMSO: 34 mg/mL (199.72 mM); Ethanol: 19 mg/mL (111.61 mM); Water: Insoluble;
熔点
244-249°C
安全和危险性（GHS）
象形图
信号词
警告
危险声明
H227: 可燃液体
预防措施声明
P210: 远离热源，热表面，火花，明火和其他点火源。 - 禁止抽烟。
P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。
P370+P378: 火灾时：使用干砂、干粉或抗醇泡沫灭火。
P403+P235: 存放在通风良好的地方。保持低温。
P501: 将内容物/容器送到批准的废物处理厂处理
WGK Germany
3
RTECS
AM8225000
Merck Index
171
个人防护装备
Eyeshields， Gloves， type N95 (US)， type P1 (EN143) respirator filter
质检证书(CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
溶液计算器
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危险品化学品经营许可证（带存储）