| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| A426427-1ml |
1ml |
现货  |
|
| 英文别名 | 4-[(7-Chloro-4-quinolinyl)amino]-.alpha.-(diethylamino)-o-cresol | Alphaquine | Amodiaquine (USP/INN) | Amodiaquine [USP:INN:BAN] | 7-Chloro-4-(3-diethylaminomethyl-4-hydroxyanilino)quinoline | C07626 | 4-[(7-chloroquinolin-4-yl)amino]-2-(diethylaminometh |
|---|---|
| 规格或纯度 | Moligand™, 10mM in DMSO |
| 英文名称 | Amodiaquine |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
阿莫地喹具有抗疟疾和抗炎作用。 Amodiaquine (Amodiaquin) 是一种4-氨基喹啉类抗疟剂，是一种有效的具有口服活性的组胺 N-甲基转移酶 (histamine N-methyltransferase) 抑制剂。Amodiaquine 也是一种 Nurr1 激动剂，可特异性结合 Nurr1 的配体结合域，EC50 为 ~20 μM。抗炎作用。 Amodiaquine is both anti-malarial and anti-inflammatory. |
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| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| 分子类型 | 小分子 |
|---|---|
| IUPAC Name | 4-[(7-chloroquinolin-4-yl)amino]-2-(diethylaminomethyl)phenol |
| INCHI | InChI=1S/C20H22ClN3O/c1-3-24(4-2)13-14-11-16(6-8-20(14)25)23-18-9-10-22-19-12-15(21)5-7-17(18)19/h5-12,25H,3-4,13H2,1-2H3,(H,22,23) |
| InChi Key | OVCDSSHSILBFBN-UHFFFAOYSA-N |
| Canonical SMILES | CCN(CC)CC1=C(C=CC(=C1)NC2=C3C=CC(=CC3=NC=C2)Cl)O |
| Isomeric SMILES | CCN(CC)CC1=C(C=CC(=C1)NC2=C3C=CC(=CC3=NC=C2)Cl)O |
| 分子量 | 355.86 |
| Reaxy-Rn | 300962 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=300962&ln= |
| 熔点 | 208 dec. |
|---|---|
| 分子量 | 355.900 g/mol |
| XLogP3 | 2.600 |
| 氢键供体数Hydrogen Bond Donor Count | 2 |
| 氢键受体数Hydrogen Bond Acceptor Count | 4 |
| 可旋转键计数Rotatable Bond Count | 6 |
| 精确质量Exact Mass | 355.145 Da |
| 单同位素质量Monoisotopic Mass | 355.145 Da |
| 拓扑极表面积Topological Polar Surface Area | 48.400 Ų |
| 重原子数Heavy Atom Count | 25 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 406.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| Concentration(Compounding value) | 9-11（mmol/L） |
|---|---|
| Record the entire process by video | Conform |
| 1. Yang Jinlan, Gao Yulan, Yang Li. (2022) Capillary-based fluorescence microsensor with polyoxometalates as nanozyme for rapid and ultrasensitive detection of artemisinin. MICROCHIMICA ACTA, 189 (1): (1-8). [PMID:34964917] [10.1007/s00604-021-05126-z] |
| 1. Yang Jinlan, Gao Yulan, Yang Li. (2022) Capillary-based fluorescence microsensor with polyoxometalates as nanozyme for rapid and ultrasensitive detection of artemisinin. MICROCHIMICA ACTA, 189 (1): (1-8). [PMID:34964917] [10.1007/s00604-021-05126-z] |
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