计算溶液所需的质量、体积或浓度。
为什么选择此级别
，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
-20°C储存,干燥。超低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
Product introduction：
SAT(PEG)4 is a long-arm (18.2 angstroms), pegylated form of SATA, a sulfhydryl-addition reagent for covalent modification of primary amines to facilitate controlled, heterobifunctional crosslinking.
Features of SAT(PEG)4:
• Thiolate and PEGylate primary amines in one step
• Add sulfhydryl groups for heterobifunctional crosslinking without compromising protein solubility
• NHS-activated for efficient PEGylation of primary amines at pH 7-9; reaction of NHS-ester group results in formation of stable, irreversible amide bonds
• Pure compound with defined structure and molecular weight, ensuring reproducible protein-modification effects
• PEG spacer provides unique advantages, including increased stability, reduced tendency toward aggregation and reduced immunogenicity
SAT(PEG)4 is the abbreviation for N-Succinimidyl S-acetyl(thiotetraethylene glycol), an amine-reactive reagent for PEGylating and adding sulfhydryl groups to proteins and other amine-containing molecules. LikeSATA and other S-acetyl (SAT) reagents, SAT(PEG)4 is most frequently used in bioconjugation methods to incorporate sulfhydryl (—SH) groups into proteins as part of a two-step or heterobifunctional crosslinking strategy. The SAT group prevents oxidation of the sulfur atom but is easily removed by treatment withhydroxylamine when the unprotected sulfhydryl group is needed for conjugation. The polyethylene glycol (PEG) spacer arm in SAT(PEG)4 minimizes steric hindrance and provides added solubility to the modified and conjugated molecules.
Specific reactivity to primary amines (e.g., lysine residues in proteins) occurs via the NHS-ester group. Spontaneous reaction in phosphate or other non-amine buffer at pH 7-9 results in formation of stable, covalent, amide bonds. Upon deprotection of the sulfhydryl group withhydroxylamine, molecules that have been modified with SAT(PEG)4 can be reacted with other proteins or surfaces that have been maleimide-activated with heterobifunctional crosslinkers likeSulfo-SMCC orSM(PEG)n Reagents.
• Reactive Moiety:Active Ester,Succinimidyl Ester,NHS Ester
• Crosslinker Type:Heterobifunctional
• Form:Liquid
• Spacer:Long, Pegylated
Features of SAT(PEG)4:
• Thiolate and PEGylate primary amines in one step
• Add sulfhydryl groups for heterobifunctional crosslinking without compromising protein solubility
• NHS-activated for efficient PEGylation of primary amines at pH 7-9; reaction of NHS-ester group results in formation of stable, irreversible amide bonds
• Pure compound with defined structure and molecular weight, ensuring reproducible protein-modification effects
• PEG spacer provides unique advantages, including increased stability, reduced tendency toward aggregation and reduced immunogenicity
SAT(PEG)4 is the abbreviation for N-Succinimidyl S-acetyl(thiotetraethylene glycol), an amine-reactive reagent for PEGylating and adding sulfhydryl groups to proteins and other amine-containing molecules. LikeSATA and other S-acetyl (SAT) reagents, SAT(PEG)4 is most frequently used in bioconjugation methods to incorporate sulfhydryl (—SH) groups into proteins as part of a two-step or heterobifunctional crosslinking strategy. The SAT group prevents oxidation of the sulfur atom but is easily removed by treatment withhydroxylamine when the unprotected sulfhydryl group is needed for conjugation. The polyethylene glycol (PEG) spacer arm in SAT(PEG)4 minimizes steric hindrance and provides added solubility to the modified and conjugated molecules.
Specific reactivity to primary amines (e.g., lysine residues in proteins) occurs via the NHS-ester group. Spontaneous reaction in phosphate or other non-amine buffer at pH 7-9 results in formation of stable, covalent, amide bonds. Upon deprotection of the sulfhydryl group withhydroxylamine, molecules that have been modified with SAT(PEG)4 can be reacted with other proteins or surfaces that have been maleimide-activated with heterobifunctional crosslinkers likeSulfo-SMCC orSM(PEG)n Reagents.
• Reactive Moiety:Active Ester,Succinimidyl Ester,NHS Ester
• Crosslinker Type:Heterobifunctional
• Form:Liquid
• Spacer:Long, Pegylated
规格
别名
Aladdin™ SAT(PEG)4(聚乙二醇化 N-琥珀酰亚胺基 S-乙酰硫代乙酸酯)
英文名称
Aladdin™ SAT(PEG)4(PEGylated N-succinimidyl S-acetylthioacetate)
储存条件
-20°C储存,干燥
运输条件
超低温运输
名称和识别符
分子类型
聚合物
技术文档
高级数据
产品属性
| Reactivity | Amine |
|---|
化学和物理性质
溶解性
DMF,DMSO
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
溶液计算器
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